05多基因遗传 温越.docx

Genetic disorders with complex inheritance （多基因遗传疾病） 1 2 ; 1 2 qualitative traits PKU quantitative traits 3 A F1 B F1 F2 C F2 F1 D 3 1 susceptibility liability threshold heritability ,h 2 0-1 2 A B C D 4 Edward f= P 1 f P 2 P=0.1%-1% h 2 =70%-80% 3 5 1 haplotype 2 3 p1 p2 h=p1*p2 h 4 5 GWAS;