1、Cancer metastasis,What is metastasis?,Cancer Stem Cells,motivate and maintain the growth of cancer cellspotentiality plasticity make them easy to survive,Hypothesis of tumor metastasis,Tumor metastasis,The phases of Cancer metastasis,俞仁涛,Invasion(侵犯) Intravasation（内渗） Extravasation（外渗）,Invasion,1.St
2、able cell movable cell 2.Protein expression3.Movement mechanism,Relative genes,Intravasation,1.Angiogenesis 2.Immune escape,Extravasation,The inverse process of invasion,The process of Tumor metastasis,Malignant Tumor metastasis pathway 恶性肿瘤常见的转移途径,Common metastasis pathway,1. lymphatic metastasis 淋
3、巴道转移2. hematogenous metastasis 血道转移3. implantation metastasis 种植性转移,Process ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenous metastasis,1. Lymphatic metastasize,2.Hematogenous metastasis,lung,liver,Metastasis pathway,（1） Body vein lung （2） Portal vein liver （3） pulmonary
4、 veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ）,3.Implantation metastasis,Chest Celiac Pericardial cavity,Bioremediation 生物治疗,Low side effects,Wide range,Clear goal,Mechanism of cell metastasis,Cell adhesion molecule(CAM) Degradation of extracellular matrix Motility of tumor cells Forma
5、tion of vessels Regulation of gene expression Immunization,Cell adhesion molecule(CAM),Cadherin Integrins Selectin IgSF others,Degradation of extracellular matrix,丝氨酸蛋白酶类 半胱氨酸蛋白酶类（ Caspase家族） 天冬氨酸蛋白酶类 基质金属蛋白酶类（MMPs）,Degradation of extracellular matrix,Proteoiytic enzymes (蛋白水解酶)溶解ECM,ECM是肿瘤侵袭和转移的天然屏
6、障,Motility of tumor cells,Motility types:Random movementDirectional movement,Motility factors: Autoecrine paracrine,Formation of vessels,Tumor metastasis relys on the forming of vessels.,Brief Introduction to Molecules in Cancer Metastasis,Three Sections,Tumour angiogenesisDisaggregation Intravasation,Tumour angiogenesis,Tumour angiogenesis has laid the foundation for tumour survival and tumour metastasis .,Tumour angiogenesis,Disaggregation,Broken down,Disaggregation,Upa,Cathepsins,MMPs,Disaggregation,Intravasation,
