1、Biochemical ReactorHydrocortisone is an important hormone products, annual exports earned the country substantial foreign exchange, Shandong Xinhua Pharmaceutical hydrocortisone product of the workshop is the one of the most important production unit, the plant is 15 m 3 oxidation of the original re
2、action fermentation tanks, ventilation ratio of 1:01. 012, stirring for the worm-type impeller, the production process for the real consumption.Hydrocortisone is the function of oxidative fermentation tank air evenly dispersed in the liquid phase, the microbial oxidation reaction catalyzed, in order
3、 to improve the gas-liquid dispersion effect, increase the dissolved oxygen concentration and oxygen mass transfer rate, the device diameter 2400mm, straight height of 5000mm, the new design of 25 m 3 fermentation tank mixing impeller by three block, bend the bottom of six leaf discs worm, the upper
4、 and middle for the SPIDI impeller type axial flow mixing, stirring speed 138 r / min , electrical power is still 55kW, after years of practice, proved that the mixing system:(1) so that the whole fermentation tank to be more evenly mixed, in addition to the radial flow and axial flow impeller stirr
5、ing combination of enhanced dispersion of air bubbles and improve dissolved oxygen concentration in the broth, increase the hydrocortisone The yield of oxidation.(2) to determine by actual, real decline in current consumption, which means that energy consumption is reduced.(3) In addition, using a c
6、ombination of axial flow and radial flow mixer, due to strengthening macro-mixing, and thus reduce the operating personnel and the physical and chemical properties of materials caused by fluctuations in reaction yield, reduced quality between batches can fluctuations, stability, technical and econom
7、ic indicators of production.In order to expand production, the factory decided to oxidative fermentation tank hydrocortisone zoom to 50 m 3, the volume of production in the hydrocortisone is the largest chemical and biological reaction tank, in concluding the fermentation tank 25 m 3, based on the D
8、esign began in 1999 to enlarge, zoom in on the tank design is not only the geometry, mass and heat transfer efficiency, mixing time, mixing impeller, oxygen rate, bubble volume and the total biomass of the shear force on the impeller and other factors were taken into account OK, the tank diameter is
9、 3200mm, tube diameter is 7000mm, with external coil for heat transfer, mixing impeller is a radial flow impeller block to improve the dispersion of air bubbles, the upper and middle with improved axial flow impeller, stirring speed 130 r / min, the power per unit volume than the 25 m 3 can be furth
10、er decreased, the use of 95kW motor, proven, and 50 m 3 tank success biochemical reaction, oxidation reaction yield is improved, the monomer volume of fermentation The liquid further decrease power consumption; stability of the operation to obtain satisfactory results, and 50 m 3 new fermentation ta
11、nks in the oxidation of cortisol in the operations and increase the plants labor productivity, and reduce the production of the reaction costs, and achieved good results.From the fermentation equipment design, the use of outer coil as the heat transfer surface, 50 meters removed within 3 fermentatio
12、n tank coil, so that the tank becomes empty Chang, an increase of about 1% of the volume, and facilitate the cleaning of Bacterial contamination of the tank to reduce played a useful help; outside the coil was not only a good heat transfer, but also to strengthen the circle as a tank, thus greatly r
13、educing the wall thickness of straight body, saving the material and reduce the cost; Stir the addition of stabilizer shaft, reducing the rock shaft, and thus 50 m 3 fermentation tank in the elimination of the bottom bearing; third type of coupling used to facilitate the maintenance of the stirring
14、shaft.Erythromycin fermentation tankShaanxi Province is the country a very important erythromycin pharmaceutical manufacturing enterprises in recent years in various tertiary institutions, research institutes and factory efforts, the level of erythromycin production has been greatly improved, 70 imp
15、roved fermentation % or more, with the pharmaceutical companies in our hospital at 65 m 3 mixing erythromycin fermentation system to do a certain amount of work for raising the level of erythromycin fermentation plant in the equipment, provide some possible, based on this the original 50 m 3 ferment
16、er has been transformed, and carried out 100 m 3 with a new design of erythromycin fermentation. Erythromycin is the new 65 m 3 fermentor design description:65 m 3 fermenter equipment erythromycin diameter: 3200mm;Cylinder Height: 7500mm;Mixing Impeller: combination of impeller;Where: a block straig
17、ht blade turbines (radial flow);Three block SPIDI - I-axis (axial flow);Stirring speed: 129 r / min;Motor power: 132kW;Heat Transfer: Four groups of six semi-circular tube coil inside the flat (doubles as a full baffle);Transmission: reducer, low noise.The fermentation tank in 1999 after the design
18、is completed, the processing of production. Scientific and technical personnel in all aspects of the full support and cooperation of the normal operation of the fermentation tanks, equipment maintenance workload is extremely small, particularly the noise significantly lower than the production envir
19、onment are 50 m 3 fermentation tank, especially good news is that the lead in the process , the fermentation unit increased 70%, according to statistics, the amplitude is much higher than the original 50 m 3 fermentation tank, and in energy consumption, the volatility between the tanks were approved
20、 has been optimized.65 meters next to the fermentation tank 3 for a description of equipment design:(1) Department of mixing impeller bottom, set the stabilizers, can greatly reduce the vibration mixing system.(2) consider the abolition of the supporting shaft end bearing, the bearing and the use of
21、 reducer bearing on the rack as the main supporting points, and in the middle of the tank to set a bearing, shaft set in the stabilizer.(3) The mechanical seal used tanks are also different from conventional, using the stationary ring of the 202F for the split small spring outflow single mechanical
22、face seal, in addition to reservations with a short section to facilitate the exchange coupling beyond the mechanical seal can not remove the rack with a short section of the coupling and bearing case, the replacement of the mechanical seal stationary ring and shorten the repair time, reduce labor i
23、ntensity.(4) of the tank jacket heat transfer system is outside the semicircle and the form of a combination of heat shield.(5) the heat transfer mainly by fermentation tanks outside the semicircle jacket, set the four outer semicircle 150mm pipe jacket.(6) fermentation temperature water cooling in
24、the summer and winter use of recycled water, recycled water for cooling as long as possible to use time and reduce annual energy costs. So that by the calculation, the simple semi-circular tube with external magnetic tank somewhat less than the heat transfer area, so the addition of the six groups i
25、n order to increase heat transfer area of tube row, the row of tubes with vertical structure, the gap between the steel tubes filled bars, it also can play a full role in the bezel, which do not have to be in the tank baffle.(7) In order to facilitate the takeover of the layout of the cooling water,
26、 heat shield within the six groups by two semi-circular tube outer 200mm be banded together in order to import, export and external cooling water import and export of semi-circular tube in the direction consistent .(8) To reduce the tanks piping, the abolition of the commonly used endoscopic washing pipe, rinse the mouth with a lighted mirrors.(9) of the tank based on the users request, on the tank wall and tank parts are taken polished.
