1、SICENCE 新闻发布 作者：甘霖 稿号：NRR_D_14-00314甲钴胺为何能治疗周围神经损伤？周围神经损伤，特别是挤压伤后，可采取的治疗措施包括基因治疗、细胞治疗、神经营养因子治疗等，但都存在一些不足，如现有载体的缺陷、外源性基因持续高表达、可能产生的高昂治疗费用、细胞来源、移植手段、远期疗效评价等。甲钴胺是一种含金属元素钴的维生素B12，是与神经系统功能相关的重要因子之一， 临床上常用于促进周围神经功能的恢复，但治疗作用机制尚不清楚。来自中国无锡市第二人民医院甘霖等领导的团队发现，甲钴胺腹腔注射可改善坐骨神经夹伤小鼠坐骨神经功能，促进损伤侧神经组织生长相关蛋白43及腰脊髓 L4-L6
2、节段背根神经节中神经营养因子的表达。文章全面评价了甲钴胺对小鼠坐骨神经损伤后再生的促进作用，并探讨阐释了甲钴胺促近坐骨神经损伤修复可能的的分子机制。而甲钴胺可改善损伤周围神经有髓神经纤维的髓鞘厚度和靶肌细胞横截面积这一观点，将会对未来周围神经损伤的治疗有显著意义。该实验结果发表在中国神经再生研究（英文版） 杂志2014年 11月第22期。Article: “ Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice,“ by Lin Gan, Minquan Qian, Keqin
3、 Shi, Gang Chen, Yanglin Gu, Wei Du, Guoxing Zhu (Department of Orthopedics, Wuxi No. 2 Peoples Hospital, Wuxi, Jiangsu Province, China)Gan L, Qian MQ, Shi KQ, Chen G, Gu YL, Du W, Zhu GX. Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice. Neural Regen Res. 2014;9
4、(22):1979-1984.欲获更多资讯： Neural Regen Res Why is mecobalamin effective for peripheral nerve injury? SICENCE 新闻发布 作者：甘霖 稿号：NRR_D_14-00314Peripheral nerve injury, especially compression can be treated by gene therapy, cell therapy, and administration of neurotrophic factors. However, there are several d
5、ifficulties with the use of these approaches in humans, including finding an appropriate donor, continued elevated expression of the exogenous gene, high treatment costs, transplantation challenges, and a need for long-term efficacy evaluation. Mecobalamin is a form of vitamin B12 that contains coba
6、lt. It is an essential vitamin for nervous system functioning. It is often clinically used to promote the recovery of peripheral nerve function. However, the molecular mechanism by which mecobalamin promotes functional nerve recovery remains unclear. The team led by Lin Gan, Wuxi No. 2 Peoples Hospi
7、tal, China found that intraperitoneal administration of mecobalamin improved the functional recovery of the injured sciatic nerve, and increased the mRNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury, and of neurotrophic factors (nerve growth factor, brain-deri
8、ved nerve growth factor and ciliary neurotrophic factor) in the L46 dorsal root ganglia. An article published in Neural Regeneration Research (Vol. 9, No. 22, 2014) evaluated the promoting effect of mecobalamin on regeneration of injured mouse sciatic nerve and investigated the molecular mechanism u
9、nderlying the therapeutic effect of mecobalamin after sciatic nerve injury. In addition, this article also reported that mecobalamin thickened the myelin sheath in myelinated nerve fibers and increased the cross-sectional area of target muscle cells, which provide insights for the treatment of perip
10、heral nerve injury. Article: “ Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice,“ by Lin Gan, Minquan Qian, Keqin Shi, Gang Chen, Yanglin Gu, Wei Du, Guoxing Zhu (Department of Orthopedics, Wuxi No. 2 Peoples Hospital, Wuxi, Jiangsu Province, China)Gan L, Qian MQ, Shi KQ, Chen G, Gu YL, Du W, Zhu GX. Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice. Neural Regen Res. 2014;9(22):1979-1984.
