1、PCI 1 (GPIs) , GPIs, , , GPIs , PCI 1 1 , , 63 , 2015 9 1 , 1 1 , , , 1 min , , 1 , 4 , 190/80mmHg, , ; : 3 ( ) : 76 / , 16 / , 119/73 mmHg, , , , , , , ; , , , , , A2P2, , , , : 5.86mmol/L, 6.21mmol/L, : , , , STv1-v4 0.05-0.14mV, T : 1d , ( 100mg qd, 75mgqd) , ( 10mg qd) , ( 5 mg qd) 2d (4000AXaIU
2、/0.4 ml bid) 4d , , 5d13:00 : , 90%, 70% , 90%, , ) , 8 000IU, , PCI , (90 mg bid) 5h , 5 000.00U 50ml ; 18h , , 9d , 10d 14d, , , , 2 , , , , 12/1000000, 2 , (TTP) 1,2, : , , , , , TTP , PCI , (HIT) 5-10d , (50- 3 HIT , , 1-3 , , 5-10d, 4-6 3 , , 24h , HIT GPIs (GIT) 24h 5h , GPIs , , GPIs , RESTOR
3、E GPIs 1.1%-1.9%7-9, 10/L 0.5%9 GPIs (0.4%-1.6%) (0.2%) (0.2%-0.5%) 10 : (i) ( 12h , (iii) ( 5-7 ) , (iv) , (v) 4,10,11, , , 12 24h , , , , DIC 13 , PCI , , 24h , , 1 , , , . 5 J. , 2014, 35 (6) :578. 2 -induced acute profound thrombocytopenia after primary angioplastyJ.Asian Cardiovasc Thorac Ann,
4、2013Feb;21 (1) :74. 3 . M. : , 2013:478-480. 4Yurtda M, Yaylali YT, Alada N, et al.Acute serious thrombocytopenia associated with intracoronary tirofiban use for primary angioplastyJ.Case Rep Med, 2014, 2014:190149. 5 , , , . J. , 2015, 31 (16) :1665. 6 , , , .PCI 1 J. , 2016, 40 (10) :1079. 7A comp
5、arison of aspirin plus tirofiban with aspirin plus heparin for unstable angina.Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study InvestigatorsJ.N Engl J Med, 1998, 338:1498. 8Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patie
6、nts with unstable angina or acute myocardial infarction undergoing coronary angioplasty.The restore Investigators.Randomized Efficacy Study of Tirofiban for Outcomes and RestenosisJ.Circulation, 1997, 96:1445. 9Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angi
7、na and non-Q-wave myocardial infarction.Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISMPLUS) Study InvestigatorsJ.N Engl J Med, 1998, 338:1488. 10Rahman N, Jafary FH.Vanishing Platelets:Rapid and Extreme TIrofiban-Induced Thrombo
8、cytopenia after Percutaneous Coronary Intervention for Acute Myocardial InfarctionJ.Tex Heart Inst J, 2010, 37 (1) :109. 11Panduranga P, Sulaiman K.Severe thrombocytopenia following tirofiban infusionJ.Indian J Pharmacol, 2011, 43 (6) :726. 12 .PCI 3 J. , 2015, 5 (24) 170. 13 , , , . J. , 2012, 20 (3) :174.
