1、1第十七章 胺1命名下列化合物：（1）N-甲基-N-乙基苄基胺； （2）1，2- 环己二胺； （3）2-甲基-4- 丙氨基戊烷；（4）4-氨基戊醛；（5）N-甲基间甲苯胺；（6）二甲基环己胺氢溴酸盐2比较下列化合物偶极距的大小： (CH3)2NCN CN(H3)2N3分别比较下列各组化合物的碱性：（1）二乙胺乙胺 对甲氧基苯胺 苯胺对氯苯胺对硝基苯胺2 ，4-二硝基苯胺（2）氢氧化四甲铵 苄胺 苯胺N-乙酰苯胺（3）环己胺环己酮亚胺 邻苯二甲酰亚胺4预言下列化合物的反应： CH3C3(CH32)N2O CH3C3(CH32)N2OHSO4-+H2SO4H3CH3(CH32)N2O CH3CH3
2、2NH+HCl(32)NC2OHl-+3CH3(CH32)N2O 3CH32N(CH32)NCH2O-+NaO5完成下列反应式：(1)O2NlClNa2O3H2NClOH(2) H+CH32ZnNaONHC33 NH2C3C32N(3)ClO2N2ClNH4SClO2NH2Cl+(4)H32NOCH32OH- H2/Pt3C2H=NO23C3H2CNH23+(5)C32 -3 C2H2ONO+(6)(H3)2N2 (3)2C2HO2+(7)NHBr(CH2)4BrNBr-+(8) CH3IAg2ONH3 H3CN3CH365O3(9) +C653OHC3N2NaO2(10) KOHC3HOC2
3、5l NH2C3HON2+H+(1) NaO2OC2 O+(12)C6H5O23C(C2H5)N+ C6H5OCH2N(5)23Br2NaOH(13) H+NaO2CO-2 KI COIBr2(14) CNH2 NH2(15)CH2NH32/i CH2N2CH3OlLiAlH4CH2NCH23(16)2=OC3 2OCH3(17) H(N4)2SO3 N2 H2OH+(18)ON+ NCH2=NCH2N(19)NCH32OOHNCH3C3(20)CH2Na2Cl(HO) C2(21) 2O2/Pt NH36用简单化学方法分别鉴别下列两组化合物： SO2ClC6H5N265(3)2CHN(C)
4、Br2HOBr2HO1HClNaO2SO2ClNaOH32NHCO322H3CH2N2 NaH/2aNaOH-(2)7用化学方法分离下列混合物：NaOHCH2O3CH2NNaOH/2(1) 3 ONaCH3HCl/2OCH2O2N3l- NH2C3l-+S2ClNSO2CH3C2aH3O+3+ CH2N3C3OHCH23N23HC3NaHCO3(2) HCl/2O NH3Cl-CH3+CONaHNaOH1)2+ CH3Na3O+CH3O2323l-NaOHS2Cl NSO2CH3S2aH3O+H3O+ NH2CH3 C348写出下列反应的机理： H2ORNRCOC RNRCOCORCO-RN=
5、CO+=NH=OH22+9由甲苯、苯和不超过四个碳的醇及必要的无机试剂合成下列化合物。 FeHNO32S4 KMnO4 HCl(1)C3 CH32 CO2N COH2NCl2(2)H3hvC2lN(C3)2CH2N(3)2(3) COH3CH3OlAl N32/PdCHN23Fe Et2OH2OCH2OBr(4)NH32/PdBr2 Mg N. CrO3CH2OCH2N2 H2/NiCHO(5) CH2NOCO,HlZn2 CONHNO32S4C3(6) 3NO2 H+ZnaHNHC33 NH2C3C32N10完成下列转化：(1)COHNCH3OC3NH2 LiAl4NCH3H2OCH2OCH
6、2N(2) H+C22NH2O2CH2OCH2N2O+PCl3(3) NH3C COlBr2/OH- CHON2HN2CH3Ol H2OFeCH3O2N(4) Br2l2N C3CH3ONBr- CH3NBr5H+2OH+(5)ONCH2=2Cl CH2=2phCO3HCH22OLiAlH4(6)CH32OCl6H5NC3H32CON653C32HNC6532SO4 a (4)2SO3(7) S3 O NH211根据下列反应写出各化合物的结构： (1)2Br2(1) LiAlH4 H+NC3ONC3ONCH33INCH3+I-AgOHN(CH3)2AB DEF GCH3I(1)2AgO rBr
7、(1)2(CH3)2NI N(3) I-N(CH3) I-+(1)2AgOH(2) CH3IA B CDCH3IAgOH AgONCH33CH23 CH2=2+N33 NCH3CH3H33CH3IgO CH3CH3+ +(CH3)NO3Zn/H2OCH3OH312Prolitane 是抗抑郁药物， Tetracaine 是麻醉药物。试从苯、甲苯和不超过 4 个碳的有机原料及必要的无机试剂设计合成路线： Cl2 C2H5ONahv C3H2OCl(1) H+2O NHH3 C2lMgEt2OC2H5O+CH2OCHO2C35- CH2O2C32/PdN(2)H+ FeHNO32S4 KMnO4
8、HClC3 CH32 O2N COH2NO2N(3)2 2(3)2CH3(2)3Br 2N(3)23(2)313通过重氮盐完成下列转化： H2SO4CH3Ol(1) 2H-N3BrN2 BrNCBrN2O2Na2HBrCu2rBrNO2Br6(2)CH3NO2 FeKMnO4 HCl NaO2HBrCu2rCON2 C2 COHBr(3) H2/PdKMnO4NH23aNO2CluCN3 OCNCCH2NNaO2HCluNHNO32S4C3(4) CH3NO2 H+ZnaHNHC33 NH2C3C32NCNH3CH3FeHCl NaO2ON2 HS4(5) O2BF4COHFPCl3NH3 B
9、r2/OH-CNFFN214由苯、萘、甲苯及不超过 4 个碳的有机原料和必要的无机试剂合成下列化合物： AlC3NaOHHgZn(1) H2S4Cl OHC32OCl OCH23 COH23HOC23H2SO4AlC3 HgZn2+Fe HNO32S4ClNaHClH2Ol C23 C23OH23 CH232H232N(2)H2O FeHNO32S4 HClNaO2HCl CH3OlNO2 N2HN32S4 NHCO3O2-Br2 Br2NO2 3P2 BrBrNO2FeHCl BrBrNH2(3)HNO32S4 HClNaO2Br2 3P2FeHClC3 3N2 3N2C32Br C3BrB
10、r7(4)HClNaO2 Br2/OH-O2V5 NH3ONCO-NH2KICI(5)HNO32S43CH32 NH3NBSC2BrO2C2NHO2H2O(6)HNO32S4NO2 N2BrFeHCl HClNaO23P2Brr2Br BrBrrHCl(7) CH3OlBr2H2OFeHNO32S4 NaO2HClNO2 N2 HNO32S4NC3- BrH2O23P2FeHClNC3O2N NH2N rCu2BrBrNO2BrBrNH2Na2 rBrNaO2HCluNO3H2S4C3(8) 3NO2 H+ZnaHNHC33 NH2C3C32NCNH3CH3 3+O OHC3CH3NO3H2S
11、43(9) C3O2 FeKMnO4 HCl NaO2HBrON2 N2CO2+l- OHp=8 HN=H2OFeHNO32S4 HClNO2 H2SO4HNO32S4(10) FeCl NaO2HBrpH=823S2+l-3S N2aS3ON=OSO3H15多巴胺（Dopamine ）是存在于中枢神经及其辐射系统的化学物质，若缺少它会得震颤性麻痹症，怎样由生物碱tyramine 合成 Dopamine？8H2/PdH2SO42+ NO32S4NaCH3OlCH2N2HO CH2NCOH3CH2NCO3HO2N CH2N2HOTyramine Dopamine16叶酸可由下列反应制备，写出反应
12、机理： H2ONOH222 +Br2CHO2BrHrNOH22 COH2BrBrHBrCOH2BrNOH22 NOH2 C2BrNOH2 CH2BrCONHC2HO2N NOH2 CH2NCONHC2HOa3/2 folic aid17.()H2NCOHA B COCH2N(2H5)H3OC2HN(C25)2 2(25)(2)H+ FeHNO32S4 KMnO4 HClC3 CH32 CO2N COH2NOC2N(C3)2 CO2N(CH3)2N18.A BCCON3Cl OCl HNHC3ll H2 lN2D19. 20.CH2N3 N(CH23)221.AB(23)2 DCH32N(C3)2(3)2(CH3)22NH2.H2NCH323.CH32CH3
