1、null % h null + 8 0 % ? ? h y h v 徐才刚null 郑素萍null 黄杰null 吴谨绪null null K 1 ! null “ null ) 0. 05)a ( OR= 1. 01, P= 0.897)a ( OR= 1.17, P= 0.073)a ( aOR= 1. 26,P= 0. 414)a ? ( OR= 1.06, P= 0.850)a ? ( OR= 1. 26, P= 0.438)a 6 ( OR= 1.00, P= 1.000) = _ ( OR= 1. 26,P= 0.266) % ? ? h A M 1 b null ( 4 t 0
2、( ) V 9 F 0 % ? ? h B b1 o M ! null % ? ; ( ; h v A casenullcontrol study for assessing the relation between the incidence of malignant lymphomas andenvironmental factors in Sichuan provincenull X U Cainullgang, ZH ENG Sunullping, H UANG Jie, WU Jinnullxu. Department of Clinical Epidemiology and Hem
3、atology, H uaxi Hospital, Sichuan University,Chengdu 610041, ChinaAbstract!null Objectivenull To evaluate the relationships of malignant lymphoma ( ML) and exposurefactors, including environmental,drug using,socioeconomic level and lifestyle etc. Methodsnull (1) Hospitalnullbased casenullcontrol stu
4、dywith 12 matching was used; ( 2) 150 cases of ML and 300 controls wereresulted;( 3) logistic regression was used. Resultsnull ( 1) Adjust odds ratios ( aOR) regarding contact to organicsolvents were: benzene aOR= 2. 78, P= 0.001; banana oil aOR= 2.28, P= 0.043; paint aOR= 1.96,P= 0. 023; ( 2) aOR o
5、n pesticides contact: organic phosphorus aOR= 1.98, P= 0.034; chrysanthesteraOR= 2.57, P= 0.013; organic nitride aOR= 2.55, P= 0.003; ( 3) aOR of using aspirin was 2.36,P= 0.005; (4) dognullraising: aOR= 1.76, P= 0.034; ( 5) the aORs of intervalnullterm exposure to smalldosage Xnullray was 0.49, P=
6、0. 015,and frequently catching cold was 0.67, P= 0. 024; (6)the Pnullvalue ofdifferent occupations was more than 0. 05; cigarette smoking OR= 1.01, P= 0.897; giving up smokingOR= 1.17, P= 0. 073; alcoholnulldrinking aOR= 1. 01, P= 0.414; hairnulldyes OR= 1.06, P= 0. 850; hairnullperms OR= 1.26, P= 0
7、. 438; socioeconomic level OR= 1.00, P= 1.000 and with introversive characterOR= 1. 26,P= 0. 266. Conclusionsnull ( 1) Factors that might increase therisk of suffering from malignantlymphomas would include direct contact to organic solvents and some pesticides ( organic phosphorus,chrysanthester and
8、 organicnitride), intake of aspirin,as well as dognullraising. ( 2) Regular exposure to smalldosage Xnull ray and frequently catching cold seemed to decrease the risk of suffering from ML. ( 3)Occupation, smoking, giving up smoking, alcoholnulldrinking, hairnulldyes, hairnullperms, socioeconomic lev
9、el andintroversive character showed no significant relations to the risk of suffering from ML in this study.Key words! null Lymphoma; Environmental exposure; Casenullcontrol studynull null % ? (malignant lymphomas) f “ d K “ :S = “ 5 h (INCLEN) S f “T :610041 , + v D “ 5 h i a A Sn B 0 ? ,s % ? (Hod
10、gkin# slymphoma,HL) d % ? (nonnullHodgkin# slymphoma,NHL) , NHL v b M S = a % ? ? h q ( M 9 t 1b“ - “ Burkitt# s % ? ) h h (HIV)M 1null875null h 2003 M 10 24 10 null ChinJ Epidemiol, October 2003,Vol.24,No.10 % ? , % ? h y b# 2,3b M ? h B y S , h % ) a f J a1 + 8 ? D = S ; + 8 D = S a ? S ; g D = S
11、a ? S b E D ( ) J D , l % ? h 1 + 8 , + 8 9 h 80% by N , h ? V + 8 % ? h f b(3) 4 : h F : D M S i # , % h M F h _ % ? a h (HLaNHL)b% v F : Y a M - ( h F M 5 = )y ,sY B D ( 1 % ? h A V 4 v , 1 % ? h A V 4 v ) 4 ( h F H W H W M 1 = ) , # “ S d ? ( r B8 _ a 5 % h a = s % h a % h a / # % h h % h )b h 2
12、v V H q v , h ,| v 5 I | , 3 V b Schlesselmanw i 1R h v “ c 9 4 ,K h F 150 , v F 300 b2.Z E :(1) k : 1 4 V s Y H W (M 1 2 = ) B 42 , h F 14 , v F 28 b W B q Kappa , ( 0.81 0. 83 W b(2) e : % ? h ( 2 h E _ % h M F h M b% H ,“ $ a1 p B E 3 B , h k W b 3 94 a o 56 b % ? F M - (50.50) 1.67) ( M -53 )a v
13、 F M - ( 51. 20 ) 1. 21) ( M - 56 )b % ? n Q C H W = 1 11 n b2. y s :(1) % ? 1 “ :h F v F 1 , 7 (4. 7%)a11 (3.7%);l 27 ( 18.0%)a47 ( 15. 7%) ; 43 ( 28.7%)a72 ( 24. 0%) ; / n 23 ( 15.3%)a66 ( 22. 0%) ; # 50 ( 33.3%)a104 ( 34.6%)b OR= 0.91, P=0. 262, 95%CI:0.78 1.07b V n h F v F s d 9 i l b(2) 0.05)b
14、4 U 200 null OR= 1.00, 95% CI: 0. 571. 57)b7 Y 1 “ f aE V 1 “ f a # h , E d 9 s b(6) 3 y % ? 1 “ : V 3 , ! T ( P= 0.008)# ( P= 0.015) V? % ? ? h B 9 F B 1 “ b a a a ? a ? # ! ? C 9 F % ? ? h B bV 3 null h F v F 3 y Z y s y h F v F OR (95% CI) 55 null null 109 null null 1.01(0.86 1.17) + 20 34 1.17(0
15、.98 1.38) # 47 68 0.86(0.73 1.01) ? a ? 70 153 1.18(0.68 1.96)! 32 81 0.72(0.44 1.16)! 45 58 1.82(3.41 88.86) *! T 51 61 1.61(1.35 10.07) * *null null * P 200gnull null 3. y s : | y s T P (0. 20 y , H q logistic B s , T n V 4bV 4 null % ? B y H q logistic B s y s M aOR (95%CI) y s M aOR (95% CI)& 2.
16、78(1.68 14.32) # 2.36(2.43 8.44) #p 1.01(0.84 2.14) b 2.59(2.21 9.45) *P 2.28(2.47 7.32) * 1.01(0.81 1.57) 1.96(2.12 7.36) * ! 0.66(0.43 1.42) j 0 1.98(3.41 15.49) * ! 1.76(6.24 71.32)* j 0 2.57(2.39 110.60)* ! T 0.63(0.41 1.25) j 0 2.55(2.67 13.36) # 0.67(0.41 0.97) * e 0.91(0.38 1.14) XL 0.49(0.26
17、 0.68) *null null * P 21 ? V P ? 3 NHL B 9 F 3 7 6b P 4 | P NHL ? 3 B 9 F 2.4 , OR 4.57b YV ! 9 h v ? C , % ? ? h B 9 F ( j 0 a aP a& 1 b 5 S 9 , ( b t % ? ? h B 9 F Es b# ,Brandt 8 t V P 8 ? 3 M , 14| 8 q32 b ? C y % ? ? h B 9 F 1 “ , 4 ( j 0 B t 4 9 F % ? h B M b 7 , L = ?C $ ( j 0 4 B y y , B t g
18、 1 E , P j 0 by N ( j 0 4 B A “ bLinet 9 - Q ? C , PNHL? 3 B 9 F , RR 2.1bBrown 10? C , P 0 F NHL ? h B 9 F K A , OR 2. 5 4. 8b 7 Tavani 11 h v ? C , ( NHL ? 3 1 bZahm 12 , NHL ? 3 1( OR= 1.0, 95% CI:0.8 1.1)b g ? C , ( OR= 1. 01, 95% CI: 0.86 1. 17) # ( OR= 1.17,95%CI:0.98 1.38) 9 F % ? ?h B b P b
19、V ? 9 F % ? ?h B y b# , B b ! , V ? 9 F B t h 13 ,V 7 P % ? ? h B 9 F bXL v ? % T ,y N w l 4 s XL v V % ? ? h B y N bB t 14 , T L 3 0 , 0 s - b 4 v a H W , 0 o 25 - ? 3 NHL B A 9 F b V ? O 8 3 f d + s F 8 , t F 8 ? % 9 B T , N ? 3 % ? B b h v , V L # L 4 , “ - g Q , B b 2 M f 4 P D f J 1 y b M T D f
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23、hm SH,Weisenburger DD,SaalRC,et al.The role of agriculturalpesticideuse in the development of nonnullHodgkin# s lymphoma inwomen.Arch EnvironHealth,1993,48353null358.8 Brandt L, Kristofferson W, Olsson H, et al. Relation betweenoccupational exposure to organic solvents and chromosomeaberrationsinnon
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25、g andrisk of nonnullHodgkin# s lymphoma and multiple myeloma. Cancer Causes andControl,1992,349null55.11 Tavani A, Negri E, Franceschi S, et al. Smoking habits and nonnullHodgkin# s lymphoma: a casenullcontrol study in northern. Italy PrevMed,1994,23447null452.12 Zahm SH, Weisenburger DD,Holmes FF,
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