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3、, , 16 , , , , 17 ) , , , 18 , , 19 20 , , , 90% , , , , , , , , ; , , , , ; , ; , , , , ; ; ; ; ; , , , , 21 , , , , , , 90% , , , , , , , TNF- -1 IL-6 , , , , , , , , , 1 , , , . J. , 2017, 37 (7) :1708-1709. 2Silverwood V, Blagojevic-Bucknall M, Jinks C, et al.Current evidence on risk factors for
4、 knee osteoarthritis in older adults:a systematic review and meta-analysisJ.Osteoarthritis and Cartilage, 2015, 23 (4) :507-515. 3 , , , . J. , 2014, 34 (3) :221-224. 4 , , , . J. , 2014, 29 (8) :782-784. 5Jo CH, Lee YG, Shin WH, et al.Intra-articular injection of mesenchymal stem cells for the trea
5、tment of osteoarthritis of the knee:aproof-of-concept clinical trialJ.Stem cells, 2014, 32 (5) :1254-1266. 6 , . J. , 2014, 32 (5) :1219-1221. 7 . J. , 2014, 27 (3) :28-30. 8 . S. : , 2002:149. 9 , . -1 - J. , 2017, 37 (5) :1079-1081. 10 .ZY/T001, 1-001, 9-94 S. , 1994:48-49. 11Qin Y, RongJie H.Observation of efficacy of Dextromethorphan hydrobromide capsule-s combined with fumaric acid azithromycin in treatment of chronic pharyngitisJ.Evaluatio-n and Analysis of Drug-Use in Hospitals of China, 2015, 15 (11) :1447-1449. 12 , , , . IL- IL-6 TNF- J. , 2016, 32 (3) :339-343.