1、 : : 60 , 30 , -1 , , 14 d 2 (NIHSS ) (rCBFLI) : NIHSS , rCBFLI : , , , , ; ; ; , , , , :18688468697, E-mail: , , , :13926005678, E-mail:dh_ Clinical study of Safflower yellow pigment on the improving the cerebral perfussion in patients with acute cerebral infarction LIU Qing HUANG De-hong HUANG Jia
2、n-hong WANG Cheng-yin XU Xing-yi WENG Xu-liang LIN Qiao-yang Department of Encephalopathy, Guangzhou Hospital of Traditional Chinese Medicine; Abstract Objective:To study the effect of Safflower yellow pigment on improving the cerebral perfussion in patients with acute cerebral infarction.Methods:60
3、 patients with acute cerebral infarction were randomly divided into treatment group and control group, 30 patients in each group.Both groups were given conventional treatment, the treatment -1beside the conventional treatment, intravenous infusion, for 14 days in a row.Record neural function score w
4、ith NIHSS and cerebral blood flow loss index (rCBFLI) before and after treatment.Results:safflower yellow pigment can significantly improve the NIHSS scores, lower rCBFLI.Conclusion:safflower yellow pigment can improve the cerebral perfusion in patients with acute cerebral infarction, protect nerve
5、cells and improve neuro function and improve the life quality, which make it worthy of clinical promotion. Keyword safflower yellow pigment; cerebral perfussion; acute cerebral infarction; 60%80%1 , , , , , 1 2015 5 2017 5 60 , 60 , 30 (NIHSS) 2 (2014) 2.1 (1) , 3 d (2) ( ) , (3) ( ) , 24 h ( ) (4)
6、(5) CT/MRI (6) NIHSS 120 2.2 (1) (2) (3) ( ) (4) 3 , , 14 d ( : Z20050146; :50 mg; ) 100 mg, 250 m L 0.9% , , qd, 14 d 4 4.1 NIHSS 14 d NIHSS NIHSS 4.2 (r CBFLI) r CBFLI r CBFLI (transcranialdoppler, TCD) (pulsatility index, PI) :r CBFLI= (1-PI/PI0 , PI , PI0 5 SPSS 19.0 , t P0.05) , NIHSS (P0.05) ;
7、 , NIHSS , (P0.05) , 1 1 NIHSS , r CBFLI (P0.05) ; , r CBFLI , (P0.05) , 2 2 r CBFLI , , , CT (CT perfussion, CTP) , (cerebral blood volume, CBV) (cerebral blood flow, CBF) (time to peak, TTP) (mean transit time, MTT) 2 3-4, MTT , MTT TTP , MTT TTP , 5 , CTP , , , Waaijer 6 , r CBV, r CBF, r TTP r M
8、TT, willis , , , , r CBV r CBF 7, r MTT r TTP (transcranialdoppler, TCD) , PI PI , , 8 PI (r CBFLI) :r CBFLI= (1-PI/PI0 , PI , PI0 , r CBFLI r TTP r MTT , r CBV r CBF 7 , r CBFLI r CBFLI , , TCD , CTP , TCD , r CBFLI, , r CBFLI , , , , , , , ( ) 9, (TNF- 6 (IL-6) , 10-11, , , , , , 12 , , , A A 12 ,
9、 (SOD) , 13 , , (MPO) (NOS) , IL-6 TNF- 14 , IL-6 TNF- , , 15 16 , Bax , / 17-18 19-20 21 (I/R) 2 h , I/R , 22, , , , , , 1 . 2014J. , 2014, 48 (4) :246-257. 2CAMPBELL BC, CHRISTENSEN S, LEVI CR, et al.Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct coreJ.Stroke, 2011
10、, 42 (12) :3435-3440. 3KAWANO T, OHMORI Y, KAKU Y, et al.Prolonged mean transit time detected by dynamic susceptibility contrast magnetic resonanceimaging predictscerebrovascularreserveimpairmentin patients withmoyamoyadiseaseJ.Cerebrovasc Dis, 2016, 42 (1-2) :131-138. 4 . D. : , 2014. 5WAAIJER A, V
11、ALL DER SCHAAF IC, VEHHUIS BK, et al.Reproducibility of quantitative CT brain perfusion measurements in patients with symptomatic unilateral carotid artery stenosisJ.Am J Neuroradiol, 2007, 28 (5) :927-932. 6WAAIJER A, VAN LEEUWEN MS, VAN OSCH MJ, et al.Chages in cerebral perfusion after revasculari
12、zation of symptomatic carotid artery stenosis:CT measurementJ.Radiology, 2007, 245 (2) :541-548. 7 , , , . J. , 2016, 37 (2) :269-272. 8 , , , . r CBFLI J. , 2003, 23 (3) :265-268. 9 , , , . J. , 2017, 33 (6) :55-58. 10ZHANG J, FANG X, ZHOU Y, et al.The possible damaged mechanism and the preventive
13、effect of monosialotetrahexosylganglioside in a rat model of cerebral ischemiareperfusioninjuryJ.J Stroke Cerebrovasc Dis, 2015, 24 (7) :1471. 11TU XK, YANG WZ, CHEN JP, et al.Curcumin inhibits TLR2/4-NF-kappa B signaling pathway and attenuates brain damage in permanent focal cerebral ischemia in ra
14、tsJ.Inflammation, 2014, 37 (5) :1544. 12 , , . J. , 2012, 6 (14) :94-95. 13 . A - J. , 2013, 36 (3) :462-464. 14 , , , . A J. , 2012, 31 (4) :484-487. 15 , . A TNF- TF TFPI J. , 2016, 32 (2) :3-5. 16 , , , . / SH-SY5Y J. ( ) , 2016, 34 (3) :349-354. 17 , , , . J. , 2014, 28 (1) :12-14. 18 , . J. , 2012, 24 (5) :715-721. 19WANG X, MA Z, FU Z, et al.Hydroxysafflor yellow a protects neurons from excitotoxic death through inhibition of NMDARsJ.ASN Neuro, 2016, 8 (2) :23-26. 20 , , , . / SH-SY5Y J. ( ) , 2016, 34 (3) :349-354. 21 . D. : , 2011. 22 , , , . J. , 2012, 10 (2) :219-221.
