1、 : , : 2012 1 2014 6 106 , , 53 , (OXA) + (CF) + (5-Fu) (FOLFOX6) , , , , Karnosfsky , , , CD3 + , CD4 + , CD8 + , T NK (CD16 + CD56 + ) , (TNF) - (IL) -6, (CRP) -1 (HO-1) , (CEA) , (CA) 724, CA50 (MMP) -2, MMP-9, (VEGF) -A, VEGF-C : (P60 , ; (4) 3 ; (5) D2 1.4 (1) TNM T1 T4b ; (2) ; (3) ; (4) ; (5)
2、 ; (6) ; (7) ( 20151124) , , , 1.5 , FOLFOX6 , + 2 h+ 46 h, 2 1 2 , CT , , , , 2 , 4 4 , , , , R0 , , , 1 6 XELOX , ( , Z62020415) 1 / , 2 , , : 20 g, 12 g, 30 g, 10 g, 30 g, 30 g, 15 g, 30 g, 15 g, 10 g, 15 g, 15 g, 12 g, 12 g, 15 g, 10 g, 6 g , , , 1 , 2 8 , 1.6 1.6.1 , , (BMI) , , 1.6.2 (RECIST)
3、14 , ( , 4 ) , ( 4 ) , ( ) , ( , = ( + + ) / = ( + ) / 1.6.3 Karnosfsky (KPS) KPS 15, KPS 10 ; KPS 10 ; KPS 10 1.6.4 4 m L, CD3, CD4, CD8 T NK (CD16CD56) , CD4/CD8 1.6.5 (ELISA) (TNF) - (IL) -6, (CRP) -1 (HO-1) , TNF- -6, CRP, HO-1 ELISA , 141209, 140911, 131032, 140992 1.6.6 ELISA (CEA) , (CA) 724,
4、 CA50, (MMP) -2, MMP-9, (VEGF) -A, VEGF-C , CEA, CA724, CA50, MMP-2, MMP-9, VEGF-A, VEGF-C ELISA , 140708, 140622, 131211, 141230, 141214, 140714, 131109 1.6.7 WHO , 5 , 1.6.8 , , 2017 3 , 1.7 SPSS 22.0 , , t t , , P0.05 2 2.1 , , BMI, , , 1 1 , , BMI, Table 1Comparison of gender, age, BMI, tumor lo
5、cation and tumor staging in two groups 2.2 , (P0.05) , , 2 2 Table 2 Comparison of clinical efficacy of two groups 2.3 KPS , KPS , 10 37 , 69.8%; KPS , 10 21 , 39.6% , KPS (P0.05) 2.4 , CD3, CD4, CD8, CD4/CD8, NK (P0.05) , CD3, CD4, CD8, CD4/CD8, NK (P0.05) 3 2.5 , 1 d TNF- -6, CRP HO-1 (P0.01) 1 d
6、, TNF- -6, CRP HO-1 (P0.05, P0.01) , TNF- -6, CRP HO-1 (P0.05, P0.01) 4 3 of immune funct n=53) 2.6 , CEA, CA724, CA50 (P0.05) , CEA, CA724 CA50 (P0.05) 5 2.7 , (P0.01) , (P0.01) 6 2.8 ( ) (P0.05) , 7 4 5 2.9 , 646 , 19.8 , 6 , 4 , 12 , 9 (P0.05) 6 relapse and metastasis- n=53) 7 Table 7 Comparison of adverse reactions in two groups 3 , , , , , , R0 , 16-17 , 18, , , , , , , , , , , , , , , , , , , , , , , , , , 19, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 20-21, , 22, , , , , , , , , , , , , , TNF- -6, CRP HO-1 1 d , , , , , , , , , CD3, CD4,
