1、 , , , 200092 1. CO 2 , 2. CO 2 1 1.CO 2 2. 3. 4. 5. 1. CO 2 3 3.1 PLLA (a) (b) 2. PLLA SEM (a) Mw: 5855 (b) Mw: 73000 2, 5855 PLLA , , , 73000 PLLA 0.5m 3m PLLA PLLA PLLA PLLA 3.2 PDLGA PDLGA ( D,L-LA:GA=70 30, MW: 65000 ) (D,L- LA:GA=85 15, MW: 58500 ) 40mg/ml 34 CO 2 14mpa 1ml/min 3(a) (b) (a) (b
2、) 3. GA PLGA PDLGA , , PLLA 2 3(a) 13m 3(b) 2 5m, 3(a) , GA LA GA PDLGA 3.3 PLLA 3.3.1 PLLA 0.0 0.1 0.2 0.3 0.4 0.5 0.025 0.030 0.035 0.040 0.045 0.050 0.055 0.060 0.065Wight of loaded drugs(g) Wight of added drugs(g) , 4mg/ml 20mg/ml PLLA 35 , 14MPa, 1ml/min , SAS 4 4(a) (b) PLLA 4. PLLA SEM (a) PL
3、LA Mw: 110000, (b) PLLA Mw: 73000 4(a) 0.54m , , 4(b) 0.17m , PLLA , 3.3.2 0. 05 0.1 0.2 0.3 0.4 0.5 5 6 0.1 0.2 0.3 0.4 0.5 0 10 20 30 40 50 60Percentage of loaded drugs(%) Wight of added drugs(g) 5. 6. 5 6, , 4. CO 2 SAS PLLA GA PDLGA Preparation and characterization of PLA microparticles by super
4、critical antisolvent Processing Teng Xinrong, Renjie, Zhangpeng Institute of Nano and Bio-Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, 200092, China Abstract: PLLA and PDLGA blank and pharmaceutical particles have been prepared by SAS processing succe
5、ssfully and spherical or elliptical particles were obtained. The effects of the molecular weight of PLLA on the morphology of particles were studied. Besides, the entrapment efficiency of drugs of pharmaceutical particles were measured and analysed. This work provides a basic for further studying degradable pharmaceutical particles using SAS technology. Key words: Supercritical carbon dioxide anti-solvent; poly (L-lactide), drug
