1、 2015 1 2017 1 74 , (37 ) (37 ) 2 90 min , 1 /2 , 0.5 g/ , 3 /d 8 , , (ORR) 37.84%, (CBR) 70.27%, 54.05% 89.19%, (P3 , Karnofsky (KPS) : (1) ; (2) ; (3) (4) ; (5) ; (6) ; (7) ; (8) ; (9) ; (10) 1.2 Roche Diagnostics Gmb H , 141003 1160107; , 0.25 g/ , 141006 1160109 1.3 (37 ) (37 ) , 18 , 19 ; 5075
2、, ; 15 , ; 21 , 16 20 , 17 ; 5375 , ; 15 , ; 22 , 15 , 2 90 min , 1 /2 , 0.5 g/ , 3 /d 8 1.4 5 (CR) : , 4 ; (PR) : 30% ; (PD) : ; (SD) : PR PD 1.5 1.5.1 KPS 6, KPS 10 , 10 , 10 1.5.2 - - - 1 (TGF- (OPN) , ELISA -2 (MMP-2) 1.5.3 (CEA) 199 (CA199) 1.6 CTCAEv4.0 7 1.7 SPSS 17.0, t , , ORR CBR 2 2.1 , C
3、R 0 , PR 14 , SD 12 , PD 11 , ORR CBR 37.84% 70.27%; CR 0 , PR 20 , SD 13 , PD 4 , ORR CBR 54.05% 89.19%, ORR CBR (P0.05) , 1 2.2 , 12 , 15 , 10 , 72.97%; 18 , 16 , 3 , 91.89%, (P0.05) , 2 2.3 , HIF- MMP-2 TGF- OPN , (P0.05) ; , (P0.05) , 3 2.4 , CEA CA199 , (P0.05) ; , (P0.05) , 4 1 Table 1 Compari
4、son on clinical efficacies between two groups 2 Table 2 Comparison on the improvement of quality of life between two groups 2.5 , , , (P0.05) , 5 5 Table 5 Comparison on adverse reactions between two groups 3 , , , , , , , 1 , VEGF , VEGF , , 2 , , 8 , , 9 , , DNA RNA , , 3 , , CEA CA199 10 , CEA CA
5、199 , (P0.05) HIF- , HIF- VEGF , 11 OPN , 12 TGF- , 13 MMP-2 , 14 , HIF- MMP-2 TGF- OPN , (P0.05) , ORR 54.05% 37.84%, CBR 89.19% 70.27%, (P0.05) , (P0.05) , (P0.05) , , HIF- MMP-2 TGF- OPN , 1 . M. 3 . : , 2011:979-997. 2 , , , . J. , 2010, 16 (20) :3168-3170. 3 , , , . J. , 2010, 25 (4) :268-271.
6、4 . (2015 ) J. , 2015, 53 (12) :1177-1191. 5 , . M. : , 2004:237-386. 6Mor V, Laliberte L, Morris J N, et al.The karnofsky performance status scale.An examination of its reliability and validity in a research settingJ.Cancer, 1984, 53 (9) :2002-2007. 7 , , . : 4.0 J. , 2012, 32 (2) :142-144. 8 , , .
7、 J. , 2015, 37 (4) :628-631. 9 , , , . J. , 2014, 23 (11) :1172-1174. 10 , . J. , 2014, 26 (2) :126-128. 11 , , , .HIF- CBRH-7919 HIF- VEGF J. , 2012, 19 (22) :1704-1708. 12 , , , . OPN, c-Met J. , 2012, 41 (36) :3823-3824. 13 , , , . TGF- J. , 2011, 46 (9) :1461-1465. 14 , , , . J. , 2006, 11 (7) :486-490.
