1、 57 50m 34 13 - + + Corneal stem cell deficiency Corneal epithelium dystrophy Corneal epithelium Degeneration Corneal epithelium dysfunction,CED Ocular Surface Disease-2013 CED MGD / XX 56 , 0.5 0.8 HSK Seifart U.Ophthalmologe 1994 912 235 1 DM 57 II DM 70 DEWS (2007). The Ocular Surface. 2007;5:163
2、-178. (DM) CED p CED Am J Ophthalmol 2001;132:17. Keiko K,Investigative Ophthalmology 32:3-11. FK506 4 / FK506 2 / 0.1% 4 Ophthalmol CHN,2012,21:166-171 66.011.1h 69.015.4h 75.027.0h 75.08.5h 7 5.000.00 4.330.52 2.500.55 2.000.00 n=8 , (P0.05) 4X 10X * * 1 3 : PTK OD Schirmers test: 0 mm OS Schirmers test: 0 mm XX 54 , OD OS + OD OD OS OS XX 51 1 + OS OD XX 52 + + + + 41 2014 2 19 “ 3 2 ” 7 0.1 2mm 0mm BUT: 3 1. 2. 3. 4. OS + + 2 2014 2 21 7 OS OS 2014 2 28 2 0.5 1 1 0.12 kp + 1. NK 2. 3. 4. OD XX 49 2015 4 10 “ 1 ” + + 30cm 12 7 + 2015 11 28
