1、 # 2010 M 4 15 2 null论null 著null % M r 4 陈海鸥null 胡小宣null 刘洪娟null 钱林null null K 1 ! null “ null 4 % M “ 5 r bZ E null 34 , Y d 22 ,Y 3 , 4 , 4 , M 1 ; ChildnullPughs ) : A ) 3 ,B) 21 ,C) 10 b - ( ? # _ , ) | i s % , | % A M # ,s Y M 1 a1 a3 a6 ? ,4 L i S a “ 5 # Q f b T null % M v s A ; 6 ALT ( 56.9
2、U/L 46. 3 U/L, TBil 47.3nullmol/L 24. 6nullmol/L, Alb 30.9 g/L 6 35.5 g/L,PT 17.9 s 16. 4 s; B 1 9 ,15 A h , 9 h ;34 ? C Q # i ? b null % M V , V “ 5 a ? ? b1 o M ! null ; % M ; The therapeutic effect of the umbilical blood stem cell transplantation in the patients with cirrhosisnull null null null
3、Chen hainullou, H uxiaonullxuan, L iu hongnullj uan, Qian lin null H ep atop athy Internal Dep artment , Pepoles H ospital of H unan Province ,Changsha 410006, ChinaAbstract!null Objectivenull To investigate the clinical therapeutic effect of umbilical blood stem cell transplantation inpatients with
4、 decompensated cirrhosis. Methodsnull Thirtynullfour patients of decompensated cirrhosis were included. Amongthem, twentynulltwo were viralhepatitis cirrhosis, three were hepatitis B and alcoholic cirrhosis, four alcoholic cirrhosis,four biliary cirrhosis and one cirrhosis with Wilsons disease. Afte
5、r isolation and purification, the umbilical blood stemcells were transplanted into the liver via hepatic artery. The biochemical index of ALT, TBil, Alb, PT and clinicalsymptomswere detectedat different times after transplantation( 1 week,1 month, 3 months,6 months). Resultsnull Most ofthe patients
6、have significant improvement in symptoms after the stem cell transplantation; At six month aftertransplantation, the mean alanine aminotransferase level decreased from 56. 9 U/L to 46.3 U/L, the mean total serumbilirubindecreased from 47.3 nullmol/L to 24.6 nullmol/L, the mean albumin level increase
7、dfrom 30.9 g/L to 35. 5 g / L,the mean prothrombin time decreased from 17.9 s to 16. 4 s. Under abdominalB ultrasonography, ascitesonly increasedin one case, but decreased significantly in 15 cases and disappeared in 9 cases. No severe adverse effect and seriouscomplicationoccurred. Conclusionsnull
8、Umbilical blood stem cell transplantation is feasible and safe, which can improveclinicalsymptoms, liver functionandblood coagulationfunction in varying degrees.Key Words!null Uumbilicalblood;Stem cell transplantation;Cirrhosisnull null T : 410006null 2 8 D h = SY T : l ,Enullmail: null null h V C ,
9、 “ 5 B v 4 5 , Z E B ) b M ? V ? a 3 i ,- X 4 , 7 n L a 8 2 # M i ? Z 5 , P “ 5 s v K byN p B 6 V a p K Z E ,X % M , | B r ,C / b Z EB aB 2008 M 12 2009 M 8 W l 34 , 3 27 , o 7 , M -18 69 , ( M - 49 ; 22 Y , 3 Y , 4 , 4 , 1 M ; ChildnullPugh s ) : A ) 3 , B ) 21 , C) 10 b - ( B ( )CT _ ,25 i ? b L i
10、 _ bALTaTBilanull81nullChinese Hepatology, Apr. 2010,Vol. 15,No. 2Alba H W (PT)b h ( = S 8 , f i f / 1 a1 a3 6 ? aPT B bB a s ( % S V U , t _ , SPSS 13.0 q s ) b null null TB a % M bALT v , s d 9 i l ; bTBil 1 1 - 6 , 3 7 S v / , 6 / A (P= 0.017); PT ( , - 1 s d 9 i l (n V 1)b a % M B _ f 25 i ? , 1
11、 h A ; 6 1 9 , 15 Ah ,9 h bV 1null % M - A 3 S M H WTBIL(nullmol/L)ALT(U/L)Alb(g/L)PT(s)null - 47. 3% 5. 1 56. 9% 6. 7 30. 9% 0. 6 17. 9% 0. 7 1 58. 6% 17. 5 55. 5% 7. 2 30. 3% 0. 7 18. 9% 0. 8 1 64. 2% 18. 2 55. 2% 8. 3 31. 0% 1. 0 17. 8% 1. 0 3 52. 0% 18. 6 54. 6% 9. 6 32. 31% 1. 1 16. 7% 1. 1 6 2
12、4. 6% 4. 3* 46. 3% 10. 1 35. 5% 2. 5 16. 4% 1. 3null null - 1 ,* P ? C ,M bALT TBil v/ ,Alb 6 , PT ,V % M , ? A , t M + Y bAlb 6 B V ? r bM bALT v / , s d 9 i l , I n V ? - ALT 6 A S 1 ,F v “ V ? z 1 N ; bAlb M 1 H ( / ,1 6 , 1 H /null82null # 2010 M 4 15 2 y ,w % h Z = S b (M Alb)# m u 1 , L b bAlb
13、 6 6 A , s d 9 i l , V “ 5 rT A ,M “ h v V ? X T b bTBil M 6 H -1 s d 9 i l ,V % M ? TBil b 6 , 4 M v “ 5 A , v h h , O 34 M ? C Q # i ? b# % M V , V “ 5 # ? a ? b“ - % M T B Z E F , 7 Z N T ,h , H W , | B r T , r 4 , % M 9 r N v “ v b null I null null D1 null Sell S. Heterogeneity and plasticity of
14、 hepatocyte lineage cells.Hepatology, 2001, 33: 738null750.2 null Theise ND, Krause DS. Bone marrow to liver: the blood ofPrometheus.SeminCell Dev Biol, 2002, 33: 411null417.3null Crompe M. Mouse liver goes human: a new tool in experimentalhepatology.Hepatology, 2001, 33: 1005null1006.4null Zan YT,W
15、ei L,Chen HS,et al.Differentiation ofbonemarrow stemcells in rat hepaticfibrogenesis environment.Zhong Hua Gan ZangBing Za Zhi, 2003, 11: 673null675.5null f 1 徐桂娟null 吴云海null null T : 110006null + g B D null null , 3 , 40 , 2005 M 4 U 5 M , 1M ,F 15 d b; , 2 (IAD), ? S UDCA, C , u a F ,i Q a , 2005
16、M 4 2007 M 5 ALT o 171 204 U/L,TBilK r 340.5nullmol/L, ALP r 2366 U/L,GnullGT 10 ULN,Chol 2 ULNb 8 CT ( 4 U 8 9 v ,i / A bh C , E J , i 8 8 (ACS)ak = II , % ) ! 4 U s L ) 3 b 2007M 5 ,h 7 M b) null IAD ? h ,B 1 & f V ? IAD 5 $ , “ - + s V f 5 W “ bT B h n h ,IAD “ - M r 0 , F A U , UDCA tIAD ( 1 * a ) i “ 5 rT , C v “ v , T , % h Z Y b# b V S ACS h , I 2 ? ,4 3 i q r , 6 y E M , B h X ? % 5 b( l : 2009null11null16)( I : ( )null83null
