1、 2014 10 21 10 Chin J Bases Clin General Surg Vo l 21 No 10 Oct 2014 1289 Diagnosis and Treatment of Necrotizing Fasciitis * * * * * * 2000 2 2014 3 20 20 15 5 3 1 52 3 11 0 39 76 11 7 1 1 15 7 18 1 6 2 12 21 1 1 10 20 13 65 2 10 5 25 R634 B DOI 10. 7507/1007-9424. 20140307 * 100730 E-mail yu-jch163
2、. com 1983 E-mail eternaldreamsina. com necrotizing fasciitis 1 2000 2 2014 3 20 1 1 1 20 15 5 3 1 52 3 11 0 39 76 11 7 1 1 15 7 5 1 1 1 1 2 0 9 d 1 d 18 90 5 25 systemic in ammatory response syndrome SIRS SIRS 7 0 2 2 4 10 7 16 6 2 mmol / L 12 3 30 1 mmol / L 1 3 20 4 2 1 1 16 9 6 1 16 15 6 1 20 18
3、 1 6 2 3 3 5 5 6 16 21 1 3 8 / 8 7 5 3 2 10 50 800 mL 138 u 5 u 9 000 mL 2014 10 21 10 Chin J Bases Clin General Surg Vo l 21 No 10 Oct 2014 1290 1 4 44 5 40 3 d 1 131 d 13 65 2 10 5 25 2 1 4 1 2 10 1 3 50 9 4 5-6 3 12 60 7 8-9 CT 10 CT 11 vacuum-assisted closure VAC 12 Fourniers gangrene severity i
4、ndex FGSI FGSI 0 4 9 13-14 9 FGSI 15 18 1 6 12 21 1 VA C VA C 3 1 Morgan MS. Diagnosis and management of necrotizing fasciitis a multiparametric approach J . J Hosp Infect 2010 75(4) 249-257. 2014 10 21 10 Chin J Bases Clin General Surg Vo l 21 No 10 Oct 2014 1291 2 Ripley DL. Necrotizing fasciitis
5、J . Prim Care Update Ob Gyns 2000 7(4) 142-147. 3 Koukouras D Kallidonis P Panagopoulos C et al. Fourniers gangrene a urologic and surgical emergency presentation of a multi-institutional experience with 45 cases J . Urol Int 2011 86(2) 167-172. 4 Sorensen MD Krieger JN Rivara FP et al. Fourniers Ga
6、n- grene population based epidemiology and outcomes J . J Urol 2009 181(5) 2120-2126. 5 Dufel S Martino M. Simple cellulitis or a more serious infec- tion ? J . J Fam Pract 2006 55(5) 396-400. 6 Lamagni TL Neal S Keshishian C et al. Severe Streptococcus pyogenes infections United Kingdom 2003-2004 J
7、 . Emerg Infect Dis 2008 14(2) 202-209. 7 Zaba R Grzybowski A Prokop J et al. Fourniers gangrene historical survey current status and case description J . Med Sci Monit 2009 15(2) CS34-CS39. 8 Ayestaray B Dudrap E Chartaux E et al. Necrotizing pyod-erma gangrenosum an unusual differential diagnosis
8、of necrotiz- ing fasciitis J . J Plast Reconstr Aesthet Surg 2010 63(8) e655-e658. 9 Barr KL Chhatwal HK Wesson SK et al. Pyoderma gangreno- sum masquerading as necrotizing fasciitis J . Am J Otolaryn- gol 2009 30(4) 273-276. 10 Sarani B Strong M Pascual J et al. Necrotizing fasciitis cur- rent conc
9、epts and reviews of the literature J . J Am Coll Surg 2009 208(2) 279-288. 11 Al-Waili NS Butler GJ Lee BY et al. Possible application of hyperbaric oxygen technology in the management of urogenital and renal diseases J . J Med Eng Technol 2009 33(7) 507- 515. 12 Tucci G Amabile D Cadeddu F et al. F
10、ourniers gangrene wound therapy our experience using VAC device J . Langen- becks Arch Surg 2009 394(4) 759-760 author reply 757-758. 13 Sroczyski M Sebastian M Rudnicki J et al. A complex approach to the treatment of Fourniers gangrene J . Adv Clin Exp Med 2013 22(1) 131-135. 14 Altarac S Katuin D
11、Crnica S et al. Fourniers gangrene eti- ology and outcome analysis of 41 patients J . Urol Int 2012 88(3) 289-293. 15 Ulu M Gedik E Girgin S et al. The evaluation of microbiol- ogy and Fourniers gangrene severity index in 27 patients J . Int J Infect Dis 2009 13(6) e424-e430. 2014-03-27 2014-08-24 CDX2 CDX2 DMH 4 DMH 1 DMH 2 2 4 15 DMH 20 mg/kg 4 32 50 mg/kg mRNA DMH CDX2 C GCC CDX2 DMH CDX2 Hum Exp Toxicol 2014 Apr 16. Epub ahead of print . 2014-05-06
