1、SICENCE 新闻发布 作者：陈亮 稿号：N201306021奥罗莫星联合骨形态发生蛋白 4 修复急性脊髓挫伤：可发挥优势叠加将奥罗莫星与骨形态发生蛋白 4 在急性脊髓挫伤局部应用，是否可以发挥各自的特色，并产生1+12 的修复效果？为验证此假设，来自中国康复研究中心北京博爱医院的李建军博士所带领的团队，建立了打击大鼠脊髓 T8 节段的急性脊髓挫伤模型，在损伤部位周围注射骨形态发生蛋白 4 细胞悬液和/或腹腔注射奥罗莫星。结果显示，奥罗莫星不影响骨形态发生蛋白 4 缩小脊髓空洞的效果，且奥罗莫星可有效抑制星形胶质细胞增殖和瘢痕形成，联合骨形态发生蛋白 4 后该作用无协同增强。且奥罗莫星与骨形
2、态发生蛋白 4 联合使用后，大鼠运动功能显著恢复。说明二者联合使用各取所长，并不抵冲各自的优势作用。为神经再生创造更好的条件，从而更加有利于损伤脊髓的修复。相关文献发表于中国神经再生研究（英文版） 杂志 2014 年 10 月第 20 期。免疫荧光染色显示，骨形态发生蛋白 4 联合奥罗莫星后，脊髓挫伤大鼠脊髓空洞面积与单独使用骨形态发生蛋白 4 治疗的大鼠无明显差异，奥罗莫星不影响骨形态发生蛋白 4 抑制空洞的作用Article: “ Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal rep
3、air after acute spinal cord contusion,“ by Liang Chen1,2, Jianjun Li1,2,3,Liang Wu4, Mingliang Yang1,2,3,Feng Gao1,2, Li Yuan5 (1 Capital Medical University School of Rehabilitation Medicine, Beijing, China; 2 Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Cen
4、ter, Beijing, China; 3 Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China; 4 Rehabilitation Center, Beijing Xiaotangshan Rehabilitation Hospital, Beijing, China; 5 Department of General Surgery, China Rehabilitation Research Center, Beijing, China)Chen L, Li JJ
5、, Wu L, Yang ML, Gao F, Yuan L. Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion. Neural Regen Res. 2014;9(20):1830-1838.欲获更多资讯： Neural Regen Res SICENCE 新闻发布 作者：陈亮 稿号：N201306021Synergistic actions of olomoucine and BMP-4 for axona
6、l repair after acute SCIWhether combination of olomoucuine and bone morphogenetic protein-4 may act synergistically and produced an effect stronger than the sum of the effects of the two drugs alone? To validate this hypothesis, Dr. Jianjun Li at Beijing Boai Hospital, China Rehabilitation Research
7、Center, China and his colleagues established a rat model of acute spinal cord injury (SCI) by impacting the spinal cord at the T8 vertebra and injected a suspension of astrocytes derived from glial-restricted precursor cells exposed to bone morphogenetic protein-4 (GDAsBMP) into the spinal cord arou
8、nd the site of the injury, and/or olomoucine intraperitoneally. Olomoucine effectively inhibited astrocyte proliferation and the formation of scar tissue at the injury site, but did not prevent proliferation of GDAsBMP or inhibit their effects in reducing the spinal cord lesion cavity. GDAsBMP and o
9、lomoucine independently resulted in small improvements in locomotor function in injured rats, and combined administration of both treatments had a significantly greater effect on the restoration of motor function. These data indicate that the combined use of olomoucine and BMP-4 creates a better env
10、ironment for nerve regeneration than the use of either treatment alone, and contributes to spinal cord repair after injury. The relevant study has been published in Neural Regeneration Research (Vol. 9, No. 20, 2014). Immunohistochemistry shows that after combined application of bone morphogenetic p
11、rotein-4 and olomoucine, the size of spinal cord lesion cavity was not significantly changed compared with application of bone morphogenetic protein-4 alone, indicating that olomoucine does not influence bone morphogenetic protein-4 inhibition of spinal cord lesion cavity. Article: “ Synergistic act
12、ions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion,“ by Liang Chen1,2, Jianjun Li1,2,3,Liang Wu4, Mingliang Yang1,2,3,Feng Gao1,2, Li Yuan5 (1 Capital Medical University School of Rehabilitation Medicine, Beijing, China; 2 Department of Spinal and
13、Neural Function Reconstruction, China Rehabilitation Research Center, Beijing, China; 3 Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China; 4 Rehabilitation Center, Beijing Xiaotangshan Rehabilitation Hospital, Beijing, China; 5 Department of General Surgery, China Rehabilitation Research Center, Beijing, China)SICENCE 新闻发布 作者：陈亮 稿号：N201306021Chen L, Li JJ, Wu L, Yang ML, Gao F, Yuan L. Synergistic actions of olomoucine and bone morphogenetic protein-4 in axonal repair after acute spinal cord contusion. Neural Regen Res. 2014;9(20):1830-1838.
