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杓型和非杓型高血压.pdf

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1、cI|:1006- 2866(2002) 04- 0389- 03 ms |:R544.1;R338. 5 DS M :ARdR邵光方,童 建( vD“, 215007)Dipper and Non-dipper Type HypertensionSHAOGuang-fang, TONG Jian( Department of Preventive Medicine, Suzhou University 215007, China)l :2001- 09- 08Te: ;Z( 3,27 ) V 3b (BP)Mi pbBP TVC?2(09: 0019:00 H) ,/( 15:00 H) ,

2、7WA/( 03:00 H) 1b l ( SBP) 24l Ho1 f( DBP)v,oS ? (10%20%bBPW W1? 1,/R0,QS/dR0b ( V?CRdR bW?1Sl0178R,v0187dR,10178 0187W HWR2b Z ,W?M1, f ( 10 mmHg, l 5 mmHgh $/R0bv TNRR( %) =? (-W (? ( 100%, V9 WSBPDBP/s1( NRR)b W/ V? (10%,h s FbV10%lR3,l10%ldR 4bh S(Ambulatory Blood Pressure Monitoring ,ABPM) , us

3、RdRh ,#i? il,C8 /b pM VTi?DX ABPMilbV ,5 Yq H, ABPM 5,6bABPM V424l H98 ,7 O V4 UpM? pbBth f /, pCsM, W/h (dR),CW 6(QR)b OhasamaABV dRQR? 35%h q A9F 6b“5 V ,dR1W/R 2 _bt 2 a 7a5 /#, a 75 B7 9b7 , R/dR , V C5s V ?bBV , # f ?CsbX,Pa f P ,dRF AM10b WBP/$ 1y 11bX 7ZRdR,W/|qTBPobWSBP/| q* 6P i (LVMI)# y A

4、M112b2m_V ,WBP/QTcs P i 113bQTcKvW QTcs ,LVMIdR9F t ,7R5 b“,dRVCi i p 1Rn 14bV ,W/h h (dR)h ,P iga5 Yqa 75%h? 3,7 O /# 15,dR1RbRedon 16?C, W/W1 ( pM) U b“ q(urinary albumin excretion rate, UAER)M1bS =9dRUAER Uc AR9bF usR-dR0 F0,RdR r ,i O HW0,9Y rTbyN,4 F0 H,1 usRdR,1 00 h f ,4 a0 HW, HW b HW “S 3 1

5、,B? HW P0, P H dbrzb HW ,4 H P db0 V B?0BQ24l H rTbR,*BQ grB-E4 F4 r4 Q07:0015: 000, V24lH T17,7ACEI g ? | zrTbdR, g F4rT z,#389# Chinese Journal of Hypertension 2002 Aug 10( 4)ACEIr4W0bh ,10 ,i gBQ0, PW/,“ V HV 6 18bR, 08:00 g: ;W VA;: ;? HKzrTb*/W g, ,Rh rT1dRzb 7dRh ,: ;W H0rKz:? AbRh ,VCAh 19b q

6、 s/ Mss?C,dRC? 3W *M9 WBP/,K )T 27b “5 ,dR1R 2 ; hX LdR1RbyN,dR RM1“Q,7 HW ZE ?dR_RMbRdRC “5ilb b HZ TbV,M B“1, 2 9NbRdRWMghZ V ilbK, o T 3+, RdR, V HW ZEh4 S$,4 rTb ID1 Degaute JP, van de Borne P, Linkowski P, et al. Quantitativeanalysis of the 24-hour blood pressure and heart rate patterns inyoung

7、 menJ.Hypertension,1991,18:199- 210. 2 Veglio F, RabbiaF, Molino P, et al. Analysisof 24-h blood pres-sure profile by fourier series during lacidipine therapyJ.Journalof Cardiovascular Pharmacology,1994,23( Suppl5):S113- 115.3 Farmer CK, Goldsmith DJ, Quin JD, et al. Progression of dia-betic nephrop

8、athy-isdiurnal blood pressure rhythm as important asabsoluteblood pressure level. Nephrology, DialysisJ,Transplan-tation,1998,13:635- 639.4 Abate G, D. Andrea L, BattestiniM, et al. Autonomic nervousactivity in elderly dipper and non-dipper patients with essential hy-pertensionJ.Aging (Milano),1997,

9、9:408- 414.5 Ohkubo T,Hozawa A,NagaiK,et al. Prediction of strokeby am-bulatory blood pressure monitoring versus screening blood pressuremeasurements in a general population: the Ohasama study J. JHypertens,2000,18(7):847- 54.6 ImaiY. Prognostic significance of ambulatory blood pressureJ.Blood Press

10、 Monit,1999,4(5):249- 56.7 Verdecchia P, Schillaci G, Borgioni C, et al. Ambulatory pulsepressure: a potent predictor of totalcardiovascular risk in hyperten-sionJ.Hypertension,1998,32:983- 988.8 Kohara K, Jiang Y, Igase M, et al. Postprandial hypotension isassociated with asymptomatic cerebrovascul

11、ar damage in essentialhypertensive patients J. Hypertension, 1999, 33(1 Pt 2):565-568.9 B V. h p 2Y)J. 镇江医学院学报,2000,10(3):438- 440.10 Cottone S, Panepinto N, Vadala A, et al. Sympathetic overac-tivity and 24-hour blood pressure pattern in hypertensives withchronic renal failureJ. Renal Failure,1995,

12、17:751- 758.11 Maeda Y, Ikeda U, Ebata H, et al. Diurnal blood pressurerhythm in hypertensiveswith parental history of strokeJ. Ameri-canJournal of Hypertension,1997,10(5 Pt 1):562- 564.12 Siche JP, Baguet JP, De GaudemarisR, et al. Kinetics of circa-dian variationsin ambulatory arterialblood pressu

13、re and cardiovascu-lar sequelae J. Archives des Maladies du Coeur et des Vais-seaux,1999,92:1139- 1144.13 S, C, ,. ? pP ig1“ J.福建医科大学学报,1998, 32(4):376- 37814 Siche JP, Baguet JP, De GaudemarisR, et al. Kinetics of circa-dian variationsin ambulatory arterialblood pressure and cardiovascu-lar sequela

14、eJ.Archives des Maladies du Coeur et des Vaisseaux,1999,92:1139- 1144.15 Bianchi S, Bigazzi R, Baldari G, et al. Diurnal variations ofblood pressure and microalbuminuria in essential hypertensionJ. JHypertens,1994,7:23.16 Redon J, Liao Y, lozano JV, et al. Ambulatory blood pressureand microalbuminur

15、ia in essential hypertension: role of circadianvariabilityJ.J Hypertens,1994,12(8):947- 953.17 M ,y .h HW Z J.广州医药,2000,31(5):9- 11.18 Reeves RA, Johnson AM, Shapiro AP, et al. Ambulatory bloodpressure monitoring: methods to assess severity of hypertension,#390# Chinese Journal of Hypertension 2002

16、Aug 10( 4)variability and sleep changes. In Ambulatory Blood Pressure Mon-itoring. Edited Weber MA, Drayer JIM, Darmstadt:Steinkopff ,1984,10:27- 34.19 White WB, Mehrotra DV, Black HR, et al. Effects of con-trolled-onset extended-release verapamilon nocturnalblood pressure(dippersversusnondippers)J.

17、 AmericanJournal of Cardiology,1997,80:469- 474.20 Nakano Y, Oshima T, Ozono R, et al. Non-dipper phenomenonin essential hypertension is related to blunted nocturnal rise and fallof sympatho-vagalnervousactivity and progress in retinopathyJ.AutonNeurosci,2001,88(3):181- 186. 21 Frisina N,Pedulla M,M

18、ento G,et al. Frequency domain of heartrate and blood pressure variability in essential hypertensive patientsduring sleep: differences between dippers and non-dippers J.BloodPress Monit,1996,1(5):425- 431.22 f . *1“CJ.中国心血管杂志,1999,4(3):181- 183.23 a *, ,f +,. d 1 :h *Y J.中华心血管病杂志,2000,28(3):181- 184

19、.24 Herpin D, Ragot S, Le Henaff J, et al. Short term blood pres-sure variability and baroreflex sensitivity in mild and moderate hy-pertensive patients 0dipper and nondipper0 J. Archives des Mal-adies du Coeur et des Vaisseaux,1996,89:1087- 1090.25 Higashi Y, Oshima T, Ozono R, et al. Nocturnal dec

20、line inblood pressure isattenuated by NaClloading in salt-sensitivepatientswith essential hypertension: noninvasive 24-hour ambulatory bloodpressure monitoringJ. Hypertension, 1997, 30(2 Pt 1): 163-167.26 Fujii T, Uzu T, NishimuraM, et al. Circadian rhythm of natr-iuresis is disturbed in nondipper t

21、ype of essential hypertension J.AmericanJournal of Kidney Diseases,1999,33:29- 35.27 Uzu T, Kimura G. Diuretics shift circadian rhythm of bloodpressure from nondipper to dipper in essential hypertensionJ. Cir-culation,1999,100:1635- 1638./ S=#M1%h )0/?ZSE5hr B “02002 M1010 - 13 /全球疾病负担0研究阐明,发展中国家的心血

22、管病的负担非常高,且在不断增长中b因此世界卫生组织健康研究全球论坛设立了/发展中国家心血管病健康研究项目0b近年来,随着我国经济的迅速增长,人民生活水平有了显著提高b但生活节奏加快,摄入高脂肪a高胆固醇食品增多,加以至吸烟a酗酒等危险因素,中风a冠心病a糖尿病a心力衰竭等与高血压密切相关的心血管病已在我国流行,发病率与死亡率逐年上升,预计到2002年将达到高峰,成为国人死亡的主要原因b为宣传和落实/发展中国家心血管病健康研究项目0,进一步促进各国心血管界医生的交流,由高血压联盟(中国)a中华心血管病杂志a北京高血压联盟研究所将于2002年10月在北京共同举办/第四届国际高血压及相关疾病学术研讨

23、会0a/发展中国家心血管病健康研究项目0b HFpbp1 = : #高血压及相关疾病的临床试验#发展中国家CVD健康研究项目#高血压及相关疾病的基础及分子研究会议时间: 2002年10月10日- 13日 会议地点:北京 交流方式:大会a小会发言 壁报交流 讨论会交流语言:英文(大会报告有翻译)a中文组织委员会秘书处:杨虎生,王淑玉北京高血压联盟研究所 北京市石景山路5号,100039或何新叶 北京市北礼士路167号 阜外医院高血压室100037 电话:010- 6833 3277 传真:010- 6835 1990E- mail 地址: (并可上网浏览有关信息,网址:)#391# Chinese Journal of Hypertension 2002 Aug 10( 4)

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