1、癌症Chinese Journal of Cancer，2008，27(3)：331336 331P13KAkt信号通路与肿瘤细胞凋亡关系的研究进展黄秀兰l2， 崔国辉1综述； 周克元1 审校Correlation of P13K-Akt Signal Pathway to Apoptosis of Tumor CellsHUANG Xiu-Lanl一，CUI Guo-Huil，ZHOU Ke-Yuanl1广东医学院生物化学与分子生物学研究所广东湛江5240232广东医学院附属医院儿科研究室广东湛江52400l1Institute of Biochemistry andMolecular Bi
2、ology，Guangdong MeScal College，删i哪，Guangdong，524023，P RChina2Laboratory of Pediatrics，Affiliated Hospital，Guangdong Medical Co广东医学院附属医院儿科研究室,广东,湛江,524001)， 崔国辉,周克元,CUI Guo-Hui,ZHOU Ke-Yuan(广东医学院生物化学与分子生物学研究所,广东,湛江,524023)刊名： 癌症英文刊名： CHINESE JOURNAL OF CANCER年，卷(期)： 2008,27(3)被引用次数： 33次参考文献(58条)1.Dou
3、glas A L;Faina B;Cindy J Y Frequent mutation of the PIK3CA gene in ovarian and breast cancer外文期刊 2005(08)2.Knobbe C B;Kieslich A T;Reifenberger G Genetic alteration and expression of the phosphoinositol-3-kinase/kt pathway genes PIK3CA and PIKE in human glioblastomas外文期刊 2005(05)3.Oda K;Stokoe D;Tak
4、etnni Y High frequency of coexistent mutations of PIK3CA and PTEN genes inendometrial carcinoma外文期刊 2005(23)4.Hartmann W;Digun-sontgerath B;Koch A Phosphatidylinositol 3-kinase/KT signaling is activated inmedulioblastoma cell proliferation and is associated with reduced expression of PTEN外文期刊2006(10
5、)5.Or YY;Hui A B;Tam K Y Characterization of chromosome 3q and 12q amplicons in nasopharyngealcarcinoma cell lines外文期刊 2005(01)6.Nyakem M;Tazzari P L;Finelli C Frequent elevation of Akt kinase phosphorylation in blood marrowand peripheral blood mononuclear cells from high-risk myelodysplastic syndro
6、me patients 2006(02)7.Samuels Y;Wang Z;Bardelli A High frequency of mutations of the PIK3CA gene in human cancers外文期刊 2004(5670)8.Piotr G;Rychahan M D;Lindsoy N Targeted molecular therapy of the PI3K pathway therapeuticsignificance of PI3K subunit targeting in colorectal carcinoma外文期刊 2006(06)9.Osak
7、i M;Oshimura M;Ito H PI3KAkt pathway:its functions and alterations in human cancer 2004(06)10.Edwards L A;Thiessen B;Dragowska W H Inhibition of ILK in PTEN-mutant human glioblastomasinhibits PKB/kt activation,induces apoptosis,and delays tumor growth外文期刊 2005(22)11.Song G;Ouyang G L;Bao S D The act
8、ivation of Akt/KB signaling pathway and cell survival外文期刊2005(01)12.Sale E M;Hodgkinson C P;Jones N P A new strategy for studying protein kinase B and its threeisofonns:role of protein kinase B in phesphorylating glycogen synthase kinase-3,tuberin,WNKI,and ATPcitrate lyase外文期刊 2006(01)13.Sharrard R
9、M;Norman J M Regulation of protein kinase B activity by PTEN and SHIP2 in humanprostate-derived cell lines外文期刊 2007(01)14.Wang J Y;Lin C H;YangC H Biochemical and biological characterization of aneuroendocrineassociated phosphatase外文期刊 2006(01)15.Maira S M;Galetic I;Brazil D P Carboxyl-terminal modu
10、lator protein (CTMP),a negative regulator ofPKB/kt and v-Akt at the plasma membrane外文期刊 2001(5541)16.Knobbe C B;Reifenberger J;Blaschke B Hypermethylation and transcriptional dowaregulation of thecarbexyl-terminal modulator protein gone in glioblastomas外文期刊 2004(06)17.Ruvolo P P;Deng X;Ito T Ceramid
11、e induces Bcl2 dephesphorylation via a mechanism involvingmitochondrial PP2A外文期刊 1999(29)18.Pim D;Massimi P;Dilworth S M Activation of the protein kinase B pathway by the HPV-16 E7oncoprotein occurs through a mechanism involving interaction with PP2A外文期刊 2005(53)19.Solit D B;Basso A D;Olshen A B Inh
12、ibition of heat shock protein 90 function downregulates Aktkinase and sensitizes tumors to taxol外文期刊 2003(09)20.Kuhajda F P Fatty acid synthase and cancer:new application of an old pathway外文期刊 2006(12)21.Wang H Q;Altomare D A;Skele K L Positive feedback regulation between Akt activation and fattyaci
13、d synthase expression in ovarian carcinoma cells外文期刊 2005(22)22.Xin M G;Deng X M Nicotine inactivation of the proapoptotie function of bax throughphosphorylation外文期刊 2005(11)23.Geswami A;Burikhanov R;de Thonel A Binding and phosphorylatian of Par-4 by Akt is essential forcancer cell survival 2005(01
14、)24.Burgering B M;Medema R H Decisions on life and death:FOXO forkheed transcription factors are incommand when PKB/kt is off duty外文期刊 2003(06)25.Vandermocre F;E1 Yazidi-Belkoura I;Adriaensseus E The antiapoptotic effect of fibroblast growthfactor-2 is mediated through nuclear factor-kB activation i
15、nduced via interaction between Akt andIkB kinase-in breast cancer cells外文期刊 2005(35)26.Jeong S J;Pisc-Musison C A;Radonovich M F Activated Akt regulates NF-kB activation,p53 inhibitionand cell survival in HTLV-1 transfolmed cells外文期刊 2005(44)27.Mayo L D;Donner D B The PTEN,Mdm2,p53 minor suppressoro
16、ncoprotein network外文期刊 2002(09)28.Wee K B;Aguda B D Akt versus p53 in a network of oncogenes and tumor suppressor genes regulatingcell survival and death外文期刊 2006(03)29.Strano S;Monti O;Pediconi N The transcriptional coactivator Yesassociated protein drives p73genetarget specificity in response to D
17、NA damage 2005(04)30.Basu S;Totty N F;Irwin M S Akt phosphorylates the Yes-associated protein,YAP,to induceinteraction with 14-3-3 and attenuation of p73 mediated apoptosis 2003(01)31.Hidalgo M;Rowinsky E K The rapamycin-sensitive signal transductiou pathway as a target for cancertherapy外文期刊 2000(56
18、)32.Gibson E M;Henson K S;Halley N Epidermal growth factor protects epithelial-derived cells fromtumor necrosis factor-related apoptosisinducing ligand-induced apoptosis by inhibiting eytochrome Crelease外文期刊 2002(02)33.KimEC;YunB S;Ryoo IJ Comptestatin prevents apoptotic cell death:inhibition of a m
19、itochondrialcaspase pathway through AKT/KB activation外文期刊 2004(01)34.Reagan-Shaw S;Ahmad N RNA interference-mediated depletion of phosphoionositide 3-kinase activeforkhead box class o transcription factor and induce cell cycle arrest and apoptosis in breastcarcinoma cells外文期刊 2006(02)35.Rychahou P G
20、;Murillo C A;Evers B M Targeted RNA interference of PI3K pathway componentssensitizes colon cancer cells to TNF-related apoptosis inducing ligand(TRAIL)外文期刊 2005(02)36.Wang J;Karen K;Hauser J Colon carcinoma cells harboring PIK3CA mutations display resistance togrowth factor deprivation induced apop
21、tosis外文期刊 2007(03)37.Liu Y;Chen L;Ko T C Evil is a survival factor which conveys resistance to both TGF-andtaxolmediated cell death via PI3K/kt外文期刊 2006(25)38.Chang F;Lee J T;Navolanic P M Involvement of PI3K/kt pathway in cell cycleprogression,apoptosis,and neoplastic transformation:a target for ca
22、ncer chemotherapy 2003(03)39.康春生;浦佩玉;李健 反义及癌症期刊论文-癌症 2004(11)40.Levav-Cohen Y;Hanpt S;Haupt Y Mdm2 in growth signaling and cancer外文期刊 2005(03)41.Zhang R;Wang H;Agrawal S novel antisense anti-MDM2 mixed-backbone oligonucleotides:proof ofprinciple,in vitro and in vivo activities,and mechanisms外文期刊 200
23、5(01)42.Bianco R;Ciardiello F;Tortora G Chemosensitization by antisense oligonucleotides targeting MDM2外文期刊 2005(01)43.王宏梅;陈龙华;郑小康 抑制ATM/I3K 动能区表达对鼻咽癌细胞CNEI辐射增敏的研究期刊论文-癌症 2006(09)44.Ohta T;Ohmichi M;Hayasaka T Inhibition of phosphatidylinositol 3 kinase increases efficacy ofcisplatin in in vivo ovar
24、ian cancer models外文期刊 2006(04)45.Barnes N L;Warnberg F;Famie G Cyclooxygenase-2 inhibition:effects on tumour growth,cell cyclingand lymphangiogenesis in a xenograft model of breast cancer外文期刊 2007(04)46.Kondapaka S B;Singh S S;Dasmahapatra G P Perifosine,a novel alkylphospholipid,inhibits proteinkin
25、ase B activation 2003(11)47.Marsh Rde W;Rocha Lima C M;Levy D E A phase trial of perifosine in locallyadvanced,unresectable,or metastatic pancreatic adenocarcinoma外文期刊 2007(01)48.Posadas E M;Gulley J;Arlen P M A phase study of porifosine in androgen independent prostatecancer 2005(10)49.Argiris A;Co
26、hen E;Karrison T A phase trial of perifosine,an oral alkylphospholipid,inrecurrent or metastatic head and neck cancer 2006(07)50.Bailey H H;Mahoney M R;Ettinger D S Phase study of daily oral perifosine in patients withadvanced soft tissue sarcoma外文期刊 2006(10)51.Meuillet E J;Ihle N;Baker A F In vivo
27、molecular pharmacology and antitumor activity of thetargeted Akt inhibitor PX-316外文期刊 2004(10)52.Mandal M;Kim S;Younes M N The Akt inhibitor KP372-1 suppresses Akt activity and cellproliferation and induces apoptosis in thyroid cancer cells外文期刊 2005(10)53.Koul D;Shen R;ergh S Inhibition of Akt survi
28、val pathway by a small-molecule inhibitor in humanglioblastoma外文期刊 2006(03)54.Zhang M;Fang X;Liu H Blockade of AKT activation in prostate cancer ceils with a small moleculeinhibitor,9-chloro-2-methylellipticinium acetate (CMEP)外文期刊 2007(01)55.Atkins M B;Hidalgo M;Stadler W M Randomized phase study o
29、f multiple dose levels of CCI-779,anovel mammalian target of rapamycin kinase inhibitor,in patients with advanced refractory renal cellcarcinoma外文期刊 2004(05)56.Christian T;James R;Zoran F Small-molecule MDM2 antagonists reveal aberrant p53 signaling incancer:implications for therapy 2006(06)57.Adach
30、i S;Leoni L M;Carson D A Apoptosis induced by molecular targeting therapy in hematologicalmalignancies外文期刊 2004(1-2)58.Campiglio M;Olgiati C;Normanno N Inhibition of proliferation and induction of apoptosis in breastcancer cells by the epidermal growth factor receptor (EGFR) tyresine kinase inhibito
31、r ZD1839(Iressa) is independent of EGFR expression level外文期刊 2004(02)本文读者也读过(3条)1. 吴日平.黄昌明.WU Ri-ping.HUANG Chang-ming PI3K/Akt信号通路与肿瘤关系的研究进展期刊论文-医学综述2009,15(10)2. 孙晓杰.黄常志.Sun XJ.Huang CZ PI3K-Akt信号通路与肿瘤期刊论文-世界华人消化杂志2006,14(3)3. 曾慧敏.王丹红.刘文贤.ZENG Hui-min.WANG Dan-hong.LIU Wen-xian PI3K/Akt通路与肿瘤治疗期刊论文
32、-中国肿瘤生物治疗杂志2008,15(1)引证文献(34条)1.徐浩 p-Akt、p-mTOR在子宫内膜腺癌中的表达及意义期刊论文-齐齐哈尔医学院学报 2013(21)2.穆庆.李百鸥 磷脂酰肌醇3激酶和蛋白激酶B在上皮性卵巢癌组织中的表达及临床意义期刊论文-中国医师进修杂志 2013(18)3.赵陈琛.顾康生 PI3K/Akt/mTOR在表阿霉素抑制Jurkat细胞增殖和诱导凋亡中的作用期刊论文-临床肿瘤学杂志2012(9)4.杨慧.倪丽.马豫茜.宋于刚 RNA干扰靶向抑制P13K p85表达对5-FU诱导大肠癌细胞凋亡的影响期刊论文-南方医科大学学报 2010(5)5.翟永宁.徐玲玲.沈悦
33、.XIA Hong.沈宇飞 稳定转染PTEN基因后对卵巢上皮性癌细胞磷酸酰肌醇3激酶/蛋白激酶B信号传导通路的影响期刊论文-中华妇产科杂志 2010(9)6.解智慧.孟凡鑫.于爱鸣 PI3K信号通路通过SKP2、p27调控肺癌细胞H446,A549增殖期刊论文-中国医科大学学报2009(9)7.刘斐.谭布珍 PI3K/AKT/GSK3信号通路在上皮性卵巢癌细胞增殖与耐药中的作用期刊论文-天津医药 2013(6)8.宰红艳.江春.易小平.邓公平.李宜雄 shRNA稳定抑制XIAP和survivin表达对胰腺癌细胞生物学特征的影响期刊论文-中国普通外科杂志 2012(3)9.徐立春.王耀霞.陈海燕
34、.Yang zhou 莪术醇对SGC-7901细胞Akt、P-Akt及BAD表达水平影响的初步研究期刊论文-医学研究杂志 2011(12)10.张丽丽.吴素慧.高燕燕.连俊芳 磷脂酰肌醇-3-激酶抑制剂对人宫颈癌细胞株生长的影响期刊论文-中国医疗前沿 2011(2)11.陈凯.齐瑞群.高兴华.张莉 恶性黑素瘤和色素痣中PI3K、AKT 、NRAS和ERK的表达及其意义期刊论文-青海医学院学报 2009(2)12.霍凤丽 卵巢癌基因研究的新进展期刊论文-现代医药卫生 2012(5)13.李美华.尹华.曾春辉 牙釉质细胞型颅咽管瘤基因表达的基因芯片研究期刊论文-中国临床神经外科杂志2008(12)
35、14.闵旻.高清平 姜黄素对HL60细胞PI3K/AKT信号传导通路的影响期刊论文-海南医学 2012(6)15.白桂芹.张凌燕.付逢萍.唐瑶 乙型肝炎病毒x蛋白在HBV宫内感染中的作用期刊论文-西安交通大学学报（医学版） 2011(5)16.龚晓萌.王黎明.姜汉国 PI3K/AKT信号传导通路对鼻咽癌细胞增殖和凋亡的影响期刊论文-中国组织化学与细胞化学杂志 2010(6)17.龚晓萌.王黎明.姜汉国 PI3K/AKT信号传导通路对鼻咽癌细胞增殖和凋亡的影响期刊论文-中国组织化学与细胞化学杂志 2010(6)18.马永岚.易虹.杨飞兰.张媛.王娅.王颖 雷公藤红素下调HL-60细胞P-Akt与
36、Cyclin D1蛋白表达及其诱导细胞凋亡的效应期刊论文-中国实验血液学杂志 2010(4)19.汪茗.章尧.谢向荣.戚之琳.毕富勇 冬凌草甲素通过PI3K/Akt通路诱导MDA-MB-231细胞的凋亡期刊论文-中国临床药理学与治疗学 2013(2)20.曾锦荣.莫碧文.王绩英.刘春妮.王涛.陈梅晞.陈峰 过氧化物酶体增殖因子激活受体激动剂对A549细胞裸鼠移植瘤Caspase-3、Survivin表达的影响期刊论文-中国药理学通报 2013(10)21.孙佳.赵冬耕.王明艳.赵凤鸣.许冬青.叶丽红 槲皮素对SMMC-7721肝癌细胞PI3K/AKT信号通路影响的探讨期刊论文-中国实验方剂学杂
37、志 2012(18)22.李美华.尹华.曾春辉 牙釉质细胞型颅咽管瘤差异基因表达谱分析期刊论文-实用肿瘤杂志 2008(5)23.曾锦荣.莫碧文.王绩英.刘春妮.王涛.陈梅晞.陈峰 过氧化物酶体增殖因子激活受体激动剂对A549细胞裸鼠移植瘤Caspase-3、Survivin表达的影响期刊论文-中国药理学通报 2013(10)24.王晓南.吴青.张连生.吴一品.舒砚文 PI3K/Akt抑制剂渥曼青霉素对白血病细胞增殖和凋亡的影响期刊论文-中国肿瘤生物治疗杂志 2010(1)25.白月.张林燕 三种蛋白在上皮性卵巢癌中的表达及意义期刊论文-中国医药 2011(6)26.Qing WU.Yan C
38、HEN.Guohui CUI.Yiquan CHENG Wortmannin Inhibits K562 Lukemic Cells by RegulatingPI3k/Akt Channel In Vitro期刊论文-华中科技大学学报（医学）（英德文版） 2009(4)27.顾冬生.严鸣光.罗宇维.孙尔维 LY294002对小鼠体内调节性T细胞的影响期刊论文-中国组织工程研究与临床康复 2009(31)28.王军.曹艳.罗晓晋.吴彬.陈显久 PI3K-Akt信号通路在尼古丁致牙周膜成纤维细胞细胞凋亡中的保护作用期刊论文-环境与健康杂志 2012(1)29.郑静.胡建达.黄毅.陈英玉.李静.陈
39、步远 黄芩苷对高致瘤HL-60细胞裸鼠移植瘤模型的体内抑瘤作用和机制探讨期刊论文-中国实验血液学杂志 2012(5)30.贾文韫.李宝兰.岳文涛 c-Met/ErbB3/PI3K信号通路在肺癌EGFRTKI获得性耐药中的研究进展期刊论文-肿瘤防治研究 2011(6)31.李晓洁 冬凌草甲素经线粒体途径诱导肿瘤细胞凋亡的信号通路期刊论文-肿瘤研究与临床 2010(4)32.刘春妮 过氧化物酶体增殖因子激活受体激动剂抗肿瘤的研究进展期刊论文-重庆医学 2011(33)33.赵正飞(综述).徐亮(审校) P27与AIF调控结直肠癌细胞凋亡的研究进展期刊论文-西南军医 2014(1)34.杨振华.常柏.张庚扬 PI3K/Akt信号通路调节创伤愈合的机制期刊论文-现代中西医结合杂志 2013(16)本文链接：http:/
