1、 , , , , , , ; ; ; ; , Email: (BL2014100) , , , , , , 50% 2 , 20%30%, 50%80% 1 5 19%2 , , , , , , , , , 1 , , , , , , , , , , , , , , , , , , , , , , , , , 3-4 , , , , , , , , , , 5 , , , , , , , 2 2.1 2.1.1 2.1.1. 1 6 38 , FOLFOX4 , 12 g ( ) , 12 g, 30 g, 30 g, 10 g, 30 g, 15 g, 6 g, 10 g, 15 g, T
2、CD4T (P0.05) ; , , (P0.05) ; 10.9 , 7.8 , 25.6 19.9 , (P0.05) ; VEGF miRNA-31 , (P0.05) 2.2 2.2.1 18 20 (S) - Rh3 -catenin , S , 19 20 , HT-29 , HT-29 21 RKO RKO RKO , RKO 22 HCT-116 , VEGF -catenin IIA , IIA VEGF -catenin 2.2.2 23 ( ) ( ) , (II ) , , , VEGF , 24 HT-29 , , ( ) , ( ) , , (MVD) , , (P
3、0.05) ; HME (P0.05) HIF-1a (P0.05) HME VEGF HIF-1a (P0.05) HME , VEGF HIF-1a 2.2.3 26 SD , ( ) , ( ) , , SW480 ; (26.59%vs 15.51%) , , EGFR : SW480 , , EGFR , 27 PCR Western blot HCT-116 , HCT-116 , , , HCT-116 , Bax Survivin mR-NA , Bax , Caspase-8C Caspase-3C Caspase-9P ARP , Bcl-2 Bcl-x1 , Bax/Bc
4、l-2 , PI3K AKt PI3K/AKt Caspase ARP Bcl Bax HCT-116 , 3 , , , , , , , : , , , , , , , 1 . M. : , 2001:623-624. 2Centelles JJ.General aspects of colorectal cancerJ.ISRN Oncol, 2012:139268. 3 J. , 2008, 6 (2) :111-114. 4 , , , J. , 2011, 13 (4) :166-168. 5 , . J. , 2012, 44 (3) :5-6. 6 , , , . J. , 2010 (6) :782-785. 7 , , . J. , 2009, 16 (1) :80-81.
