1、Lab 1,Biology: Exploring Life,0,Antibiotics,Too Much of a Good Thing?,Your doctor prescribes an antibiotic and specifically cautions you to take every pill. Why?,Antibiotics,Checkpoint,Antibiotics,What is an antibiotic? a. It is a toxin used by bacteria to kill molds. b. It is a drug that can kill i
2、nfectious bacteria. c. It is a chemical produced by the body to defend itself against viruses. d. Its an area with conditions that dont support life. e. None of the above are correct.,Checkpoint,Antibiotics,Human white blood cells _. a. carry oxygen and carbon dioxide to the lungs b. store antibioti
3、cs for release at sites of infection c. serve as one of the bodys natural lines of defense against microbial invaders d. gather and eliminate antibiotics from the site of an infection e. All of these are correct.,Checkpoint,Antibiotics,About half of the antibiotics produced today _. a. end up in ani
4、mal feed b. are used by field hospitals in war zones c. are shipped to third-world countries d. become useless due to developing resistance by bacterial populations e. are stored for later use,Checkpoint,Antibiotics,How do bacteria populations become drug resistant? a. Antibiotics remove drug-suscep
5、tible individuals but leave those that are drug-resistant. b. Natural selection drives bacterial populations to change. c. Some individuals are genetically resistant to antibiotics. d. All of these are correct.,Checkpoint,Antibiotics,Which of these is not an effective strategy to prevent antibiotic
6、resistance? a. Dont stockpile antibiotics. b. Dont demand antibiotics from your physician. c. Use antibiotics only as long as symptoms remain. d. Use antibiotics as prescribed. e. Dont share antibiotics with others.,Biology and Society,Antibiotics,The development of antibiotic resistance by bacteria
7、 illustrates how natural selection affects our lives. Can you name another way our society experiences the effects of natural selection?,Antibiotics,Discussion Question The development of antibiotic resistance by bacteria illustrates how natural selection affects our lives. Can you name another way
8、our society experiences the effects of natural selection?Follow-Up Questions Is it likely that insect or plant pests (weeds) might develop resistance to pesticides and herbicides? Some plants, like BT corn and BT cotton, are being engineered to include a pesticide gene. What do you predict to be the
9、 long-term success of such a strategy? What strategies should a farmer employ to prevent pests from becoming resistant?Antibiotic resistance in bacteria is not the only case in which humans are causing pressures that contribute to the natural selection of a population. Other examples include insect
10、resistance to BT corn, BT cotton, and other natural and genetically altered crops (http:/ A great deal of research is being conducted to develop strategies to prevent pest populations from developing pesticide resistance (http:/www.biotech- and Society,Biology and Society,Antibiotics,Many antibiotic
11、slike penicillinare no longer effective, but it is costly to develop replacements. Do we have an obligation to societies that cannot afford to develop these new and expensive antibiotics?,Biology and Society,Antibiotics,About 50% of the antibiotics produced today are used in the livestock industry.
12、What impact does this have on the treatment of human diseases?,Internet Research,Antibiotics,Antibacterial Soap Doesnt Prevent Viral Infection (http:/kidshealth.org/research/antibacterial_products.html) This article outlines our use and misunderstanding of antibacterial soaps. Are there concerns tha
13、t bacteria will develop resistance to antibacterial soaps?Drug Companies Snub Antibiotics (http:/ The article speculates that drug companies are spending less money and less effort to develop new antibiotics. What evidence does the author cite? What are the consequences to global health if this is t
14、he case?Is Your Meat Safe? (http:/www.pbs.org/wgbh/pages/frontline/shows/meat/safe/) This site outlines the debate over the use of antibiotics in the livestock industry. Familiarize yourself with the issues, then share your thoughts (http:/www.pbs.org/wgbh/pages/frontline/shows/meat/talk/). Was the
15、coverage fair and unbiased?,Summary,Antibiotics,We didnt have antibiotics before the 1940s. Alexander Fleming helped to develop the first antibiotic from a mold. Antibiotics work to kill infecting bacteria. Natural variations exist within bacterial populations that make some bacteria resistant to an
16、tibiotics. Abuse of antibiotics promotes the development of antibiotic-resistant bacteria.,Preventing the development of antibiotic-resistant bacteria is in the hands of every individual. What actions will you take?,Antibiotics,Five Steps of the scientific method,Observation come from others or resu
17、lts of earlier tests Questions are asked about unclear aspects of the observations: How? Why? When? Hypotheses are tentative explanation of a phenomenon phrased in such a way as to be testable. Predictions are logical, testable outcomes of the hypotheses developed by the use of deductive reasoning.
18、Predictions take the form of if (statement of hypotheses) is true, then (predictions). Tests of prediction are performed to determine if the predictions are supported (fail to falsify) or falsified.,Concept Check,Not all science discoveries strictly follow the “scientific method”. Which of the follo
19、wing would best be described as discovery science? Sequencing the human genome. Describing a new bird species from the Philippines. A project to find preserved specimens of the probably extinct Rocky Mountain locust frozen in glaciers . All of the above.,0,Answer,Not all science discoveries strictly
20、 follow the “scientific method”. Which of the following would best be described as discovery science?All of the above.,0,A Case Study of Hypothesis-Based Science In experiments designed to test hypotheses The use of control groups and experimental groups helps to control variables,0,Interpreting Dat
21、a,These two snakes look remarkably similar to each other. The coral snake (right) is very poisonous to vertebrates. Hypotheses: H1: The coral snakes bright color pattern serves to warn off potential predators. H2: The the king snake suffers less predation because it mimics or looks like the coral sn
22、ake. H3: The protection that king snakes receive by mimicking coral snake will depend on the presence of coral snakes.,0,Interpreting Data,A team of scientists designed an investigation that used artificial snakes to test the previous hypotheses. Which of the previous hypotheses are supported by the
23、 results displayed at the right? H1: The coral snakes bright color pattern serves to warn off potential predators. H2: The the king snake suffers less predation because it mimics or looks like the coral snake. H3: The protection that king snakes receive by mimicking coral snake will depend on the pr
24、esence of coral snakes. Both A and B,0,Answer,A team of scientists designed an investigation that used artificial snakes to test the previous hypotheses. Which of the previous hypotheses are supported by the results displayed at the right?Both A and B,0,Interpreting Data,Biologists placed artificial
25、 snake mimics in two different localities to test the hypothesis that looking like a poisonous snake only works where the poisonous snake is found:Outside of the coral snake rangeonly king snakes present.Inside the coral snake rangeboth coral and king snakes are present.,0,Interpreting Data,The data
26、 graphed at the right _ the hypothesis that the effectiveness of mimic coloration depends upon the presence of the poisonous model is: supports does not support is irrelevant to,0,Answer,The data graphed at the right _ the hypothesis that the effectiveness of mimic coloration depends upon the presen
27、ce of the poisonous model is: supports,0,Interpreting Data,Based on this data which of the following is a logical hypothesis or prediction? King snakes outside of the range of coral snakes will more closely resemble coral snakes than populations of king snake living within the range of coral . King
28、snakes outside of the range of coral snakes will not resemble coral snakes as closely as populations of king snakes that live within the range coral snakes. Neither prediction is valid.,0,Answer,Based on this data which of the following is a logical hypothesis or prediction?King snakes outside of th
29、e range of coral snakes will not resemble coral snakes as closely as populations of king snakes that live within the range coral snakes.,0,Controls,This case study provides an example of a controlled experiment, one that is designed to compare an experimental group (the artificial king snakes, in th
30、is case study) with a control group (the artificial brown snakes). Ideally, the experimental and control groups differ only in the one factor the experiment is designed to testin our example, the effect of the snakes coloration on the behavior of predators.,Controls,Without the control group, the re
31、searchers would not have been able to rule out the number of predators in the different test areas as the cause of the different number of attacks on the artificial king snakes. The clever experimental design left coloration as the only factor that could account for the low predation rate on the art
32、ificial king snakes placed within the range of coral snakes.,Hypothesis,Theory needing investigation: a tentative explanation for a phenomenon, used as a basis for further investigation The hypothesis of the big bang is one way to explain the beginning of the universe.,Hypothesis - defined,A conject
33、ure advanced for heuristic purposes, cast in a form that is amenable to confirmation or refutation by conducting of definable experiments and the critical assembly of empiric data; not to be confused with assumption, postulation, or unfocused speculation. Heuristic: LOGIC procedure for getting solut
34、ion: a helpful procedure for arriving at a solution but not necessarily a proof,Deduction,Conclusion drawn: a conclusion drawn from available information. Drawing a conclusion: the process of drawing a conclusion from available information. LOGIC logical conclusion: a conclusion reached by applying
35、the rules of logic to a premise. LOGIC reasoning: the forming of conclusions by applying the rules of logic to a premise,A Case Study from Ever yday Life Deductive reasoning is used in testing hypotheses as follows If a hypothesis is correct, and we test it, then we can expect a par ticular outcome,
36、0,Two important qualities of the hypotheses-based science,A hypothesis must be testable. A hypothesis must be falsifiable.A hypothesis becomes credible when repeated attempts to disprove it fail.,Introduction to Lab 1,scientific inquiry is a particular way of answering questions questions that can b
37、e answered by science must meet specific guidelines and scientific investigations must be carried out using certain rulesan investigator cannot show that his or her experiment was done according to the guidelines, then the results of that experiment will not be recognized as valid by other scientist
38、s,Introduction to Lab 1,The purpose of such guidelines can be understood by comparing them to sports records. For example, a new record set in a track and field event only counts if the meet was approved by the governing body that sets the guidelines. The site and equipment used are scrutinized to b
39、e sure that they are within the regulations and the athlete is tested for use of illicit substances. Only when these required conditions are met is the record certified as valid.,Introduction to Lab 1,In this laboratory you will learn about the basic elements of scientific inquiry and how to apply t
40、his process to solving problems.,Exercise 1.3: The Elements of an Experiment,Objectives: Define and give examples of dependent, independent, and standardized variables. Identify the variables in an experiment. Explain what control treatments are and why they are used. Explain what replication is and
41、 why it is important.,Exercise 1.3: The Elements of an Experiment,Variables are things that may be expected to change during the course of the experiment. The investigator deliberately changes the independent variable He measures the dependent variable to learn the effect of changing the independent
42、 variable. To eliminate the effect of anything else that might influence the dependent variable, the investigator tries to keep standardized variables constant.,Dependent Variables,The dependent variable is what the investigator measures (or counts or records). It is what the investigator thinks wil
43、l vary during the experiment. For example, she may want to study peanut growth. One possible dependent variable is the height of the peanut plants. Name some other aspects of peanut growth that can be measured. Number of peanuts, weight of the plants, leaf area, time to maturation. All of these aspe
44、cts of peanut growth can be measured and can be used as dependent variables in an experiment. There are different dependent variables possible for any experiment. The investigator can choose the one she thinks is most important, or she can choose to measure more than one dependent variable.,Independ
45、ent Variables,The independent variable is what the investigator deliberately varies during the experiment. It is chosen because the investigator thinks it will affect the dependent variable. Name some factors that might affect the number of peanuts produced by peanut plants.Amount of fertilizer, typ
46、e of fertilizer, temperature, amount of water, day length, genetic type of the peanuts.,Standardized Variables,A third type of variable is the standardized variable. Standardized variables are factors that are kept equal in all treatments, so that any changes in the dependent variable can be attribu
47、ted to the changes the investigator made in the independent variable.,Standardized Variables,Since the investigators purpose is to study the effect of one particular independent variable, she must try to eliminate the possibility that other variables are influencing the outcome.This is accomplished
48、by keeping the other variables at constant levels, in other words, by standardizing these variables.,Standardized Variables,For example, if the scientist has chosen the amount of fertilizer as the independent variable, she wants to be sure that there are no differences in the type of fertilizer used
49、. She would use the same formulation and same brand of fertilizer throughout the experiment. What other variables would have to be standardized in this experiment? Amount of water, temperature, day length, genetic type of peanuts.,Predictions,A hypothesis is a formal, testable statement The investig
50、ator devises an experiment or collects data that could prove the hypothesis false He should also think through the possible outcomes of the experiment and make predictions about the effect of the independent variable on the dependent variable in each situation. It is useful to think of a prediction as an if/then statement: If the hypothesis is supported, then the results will be .,
