1、噻菌灵理化性质查询资料thiabendazoleFRAC 1, B1; benzimidazoleNOMENCLATURECommon name thiabendazole (BSI, E-ISO, (m) F-ISO, BAN, JMAF); tiabendazole (INN)IUPAC name 2-(thiazol-4-yl)benzimidazole; 2-(1,3-thiazol-4-yl)benzimidazoleChemical Abstracts name 2-(4-thiazolyl)-1H-benzimidazole CAS RN 148-79-8 EC no 205-7
2、25-8 Development codes MK 360 (Merck EPA (formulation) III EC classification N; R50, R53 ECOTOXICOLOGYBirds Acute oral LD50 for bobwhite quail 2250 mg/kg. Dietary LC50 (5 d) for bobwhite quail and mallard ducks 5620 mg/kg diet. Fish LC50 (96 h) for bluegill sunfish 19, rainbow trout 0.55 mg/l. Daphn
3、ia EC50 (48 h) 0.81 mg/l. Algae EC50 (96 h) for Selenastrum 9 mg/l; NOEC for Selenastrum 3.2 mg/l. Other aquatic spp. LC50 (96 h) for shrimps 0.34, oysters 0.26 mg/l. Bees Not toxic to bees. Worms LC50 500 mg/kg soil. Other beneficial spp. Harmless to Aleochara, Typhlodromus and Chrysoperla; slightl
4、y harmful to Aphidius. ENVIRONMENTAL FATEAnimals When administered orally, thiabendazole is rapidly absorbed; up to 90% of the total dose is eliminated (about 65% in urine and 25% in faeces) within 24 hours, in both sexes. The compound is rapidly distributed to tissues, with highest levels found in
5、the heart, lungs, spleen, kidneys, and liver. The compound is essentially completely cleared from the body within 7 days in both dose groups. Thiabendazole undergoes hydroxylation at the 5-position. Plants The residue on all crops treated pre- or post-harvest is parent thiabendazole. Soil/Environmen
6、t Soil DT50 1 y (1 mg/kg, harsh conditions), 33 d (20 C, 40% MWC, 0.1 mg/kg soil), 120 d (20 C, 40% MWC, 1 mg/kg soil). Aqueous photolysis DT50 29 h (pH 5). 噻菌灵理化性质查询资料（二）ENVIRONMENTAL FATE Property Value Source/Quality Score/Other Information Interpretation Solubility - In water at 20oC (mg l-1) 水中
7、溶解度30 A5 Low 10 A5 - n-Heptane - 130 A5 - Xylene - 8230 A5 - Methanol - Solubility - In organic solvents at 20oC (mg l-1) 有机溶液中溶解度，分别是正庚烷、二甲苯、甲醇、丙酮2430 A5 - Acetone - Melting Point (oC) 熔点 297 A5 - Boiling Point (oC) 沸点 - - - Degradation point (oC) - - - Flash point (oC) 闪点 Not highly flammable A5 -
8、 P 2.45 X 1002 Calculated - Octanol-water partition coefficient at pH 7, 20oC分配系数（正辛醇/水）Log P 2.39 A5 Low Bulk density (g ml-1)/Specific gravity 相对密度1.4 A5 - 4.73 A5 - Dissociation constant (pKa) at 25oC 离解常数 Note: pKa(2) 12.00 Vapour pressure at 25oC (mPa) 蒸汽压5.30 X 10-04 A5 Volatile Henrys law con
9、stant at 25oC (Pa m3 mol-1) 亨利常数3.70 X 10-06 A5 Non-volatile Henrys law constant at 20oC (dimensionless) 亨利常数1.46 X 10-09 Calculated Non-volatile GUS leaching potential index 0.36 Calculated Low leachability Value 8.50 X 10-03 Calculated - SCI-GROW groundwater index (礸 l-1) for a 1 kg ha-1 or 1 l ha
10、-1 application rate Note - Potential for particle bound transport index - Calculated High Maximum UV-vis absorption L mol-1 cm-1 254nm and 302nm A5 - Surface tension (mN m-1) - - - Degradation: 降解Property Value Source/Quality Score/Other Information Interpretation DT50 (typical) 500 A5 Very persiste
11、nt DT50 (lab at 20oC) 365 A5 Very persistent DT50 (field) 724 A5 Very persistent DT90 (lab at 20oC) - - - DT90 (field) - - - Soil degradation (days) (aerobic) 土壤降解Note: - Value 1.2 A5 Moderately fast Aqueous photolysis DT50 (days) at pH 7 水中光解 Note - Value 203 A5 Persistent Aqueous hydrolysis DT50 (
12、days) at 20oC and pH 7 水解Note Stable pH 5 to pH 9 Water-Sediment DT50 (days) 水沉积物系统降解：4 A5 Fast Water phase only DT50 (days) 1.5 A5 Moderately fast Soil adsorption and mobility: 土壤吸附与迁移Property Value Source/Quality Score/Other Information Interpretation Kd - Koc 吸着系数 7344 A4 Non-mobile Linear Notes
13、and range EU dossier Koc range 1104-22467 mL/g, Soils=4; Other data: Koc 2500 mL/g (DW3) Kf - Kfoc - 1/n - - - Freundlich Notes and range - pH sensitivity - Handling issues: Property Value Source/Quality Score/Other Information Interpretation General N - Dangerous for the environment: R50, R53 EC Sa
14、fety Classification S60, S61 WHO Classification III - Slightly hazardous US EPA Classification (formulation) III - Caution - Slightly toxic UN Number Variable with product, usually 3077 or 3082 Waste disposal Thiabendazole; Tiabendazole; 2-(Thiazol-4-Yl)Benzimidazole; Storite; Tbz; Tbz(R); Tecto; Te
15、cto(R); Thibenzole(R); Thiabendazole (Tm); Thiabendazol; Probendazole; 2-(1,3-Thiazol-4-Yl)-1h-Benzoimidazole; 2-(1,3-Thiazol-4-Yl)Benzimidazole; 2-(4-Thiazolyl)-1h-Benzimidazole; 2-(1,3-thiazol-4-yl)-1,3-benzothiazoleMolecular Formula 分子式 C10H6N2S2Molecular Weight 分子量 218.298InChIInChI=1/C10H6N2S2/
16、c1-2-4-9-7(3-1)12-10(14-9)8-5-13-6-11-8/h1-6HCAS Registry Number 148-79-8EINECS 205-725-8Molecular Structure 分子结构式Density 密度 1.415g/cm3Melting point 熔点 298-301Boiling point 沸点 396.5C at 760 mmHgRefractive index 1.731Flash point 闪点 192.5CWater solubility 水中溶解度 0.005 g/100 mLVapour Pressur 蒸汽压 3.89E-06mmHg at 25CHazard Symbols N:Dangerous for the environment;Risk Codes R50/53:;Safety DescriptionS60:;S61:;
