1、Site of action Mechanisms Effects Clinical uses,第一节 药物的基本作用Effects of Drugs,Target,Drug,Changes in Living sysytem,Effect,Selectivity 选择性,Specificity 特异性,一、药物作用与药理效应（药效）Action and Effect of Drug,Therapeutic Effect Adverse Reaction,二、不良反应Adverse Reactions,不良反应较常见的有恶心、呕吐、上腹部不适或疼痛等胃肠道反应。较少见或罕见的有（1）胃肠道出血
2、或溃疡，表现为血性或柏油样便，胃部剧痛或呕吐血性或咖啡样物，多见于大剂量服药患者。（2）支气管痉挛性过敏反应，表现为呼吸困难或哮喘。（3）皮肤过敏反应，表现为皮疹、荨麻疹、皮肤瘙痒等。（4）血尿、眩晕和肝脏损害。 禁忌 孕妇、哺乳期妇女禁用。哮喘、鼻息肉综合征、对阿司匹林和其他解热镇痛药。,2. After effect and Withdrawal Reaction后遗效应和停药反应,第二节 药物剂量-效应关系Dose-effect Relationship,Therapeutic Index: TI, safety,第三节 药物与受体Drug and Receptors,Which one
3、 has the greater ? What ablout their affinity?,Which one has the greater ? What ablout their affinity?,Which ones are Full Agonists?,五、受体类型Receptor Types,（一）G蛋白藕连受体G protein-coupled receptors,(1) Receptor (2) G protein (3) Adenylate cyclase(AC) orPhospholipase C(PLC) orCa,Na Channels,（二) 配体门控离子通道受体L
4、igand-Gated Ion Channel Receptor,A group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (i.e., a ligand),such as a neurotransmitter,（三）酪氨酸蛋白激酶受体 Tyrosine Kinase Recptor,High affinity cell surface receptors for many polypeptide growth factors, cytokines and hormones,六、细胞内信号转导Signaling Mechanisms,cAMP cGMP Phosphatidylinositol Ca2+,30,药物方面的因素 Pharmaceutical Factors,机体方面的因素 Biological Factors,精神因素 Ssychologi Fcactors,
