1、1,Chapter 9,Sleep and Biological Rhythms,This multimedia product and its contents are protected under copyright law. The following are prohibited by law:any public performance or display, including transmission of any image over a network; preparation of any derivative work, including the extraction
2、, in whole or in part, of any images; any rental, lease, or lending of the program.,2,A Physiological and Behavioral Description Stages of Sleep Electromyogram (EMG): An electrical potential recorded from an electrode placed on a muscle. Electro-oculogram (EOG): An electrical potential from the eyes
3、, recorded by means of electrodes placed on the skin around them, detects eye movements.,3,A Physiological and Behavioral Description Stages of Sleep Alpha activity: A smooth electrical activity of 8 12 Hz recorded from the brain; generally associated with a state of relaxation. Beta activity: Irreg
4、ular electrical activity of 13 30 Hz recorded from the brain; generally associated with a state of arousal.,4,A Physiological and Behavioral Description Stages of Sleep Theta activity: EEG activity of 3.5 7.5 Hz that occurs intermittently during early stages of slow wave sleep and REM sleep. Delta a
5、ctivity: Regular, synchronous electrical activity of less than 4 Hz recorded from the brain; occurs during the deepest stages of slow-wave sleep.,5,Copyright 2004 Allyn and Bacon,6,A Physiological and Behavioral Description Stages of Sleep REM sleep: A period of desynchronized EEG activity during sl
6、eep, at which time dreaming, rapid eye movements, and muscular paralysis occur. Non-REM sleep: All stages of sleep except REM sleep. Slow-wave sleep: Non-REM sleep , characterized by synchronized EEG activity during it deeper stages.,7,Copyright 2004 Allyn and Bacon,8,Disorders of Sleep InsomniaRepo
7、rted to affect approximately 25% of the population occasionally, and 9% regularly. There appears to be no single definition of insomnia. One of the most important causes of insomnia seems to be sleeping medication. Insomnia is not a disease, but rather may be a symptom of pain, discomfort, or other
8、physical ailment.,9,Disorders of Sleep InsomniaDrug dependency insomnia: An insomnia caused by the side effects of ever increasing doses of sleeping medications. Sleep apnea: Cessation of breathing while sleeping.,10,Disorders of Sleep NarcolepsyNarcolepsy: A sleep disorder characterized by periods
9、of irresistible sleep, attacks of cataplexy, sleep paralysis, and hypnagogic hallucinations. Sleep attack: A symptom of narcolepsy; an irresistible urge to sleep during the day, after which the person awakes feeling refreshed.,11,Disorders of Sleep NarcolepsyCataplexy: A symptom of narcolepsy; compl
10、ete paralysis that occurs during waking. Sleep paralysis: A symptom of narcolepsy; paralysis occurring just before a person falls asleep.,12,Disorders of Sleep NarcolepsyHynagogic hallucination: A symptom of narcolepsy; vivid dreams that occur just before a person falls asleep; accompanied by sleep
11、paralysis.,13,Disorders of Sleep REM Behavior DisorderREM sleep behavior: A neurological disorder in which the person does not become paralyzed during REM sleep and thus acts out dreams.,14,Copyright 2004 Allyn and Bacon,15,Physiological Mechanisms of Sleep and Waking Neural Control of ArousalAcetyl
12、choline: One of the most important neurotransmitters involved in arousal.Two groups of acetylcholinergic neurons located in the pons and basal forebrain, produce activation and cortical desynchrony when they are stimulated,16,Physiological Mechanisms of Sleep and Waking Neural Control of ArousalNore
13、pinephrine: Catecholamine agonists produce arousal and sleeplessness; effects appear to be mediated by the locus coeruleus in the dorsal pons. Locus ceoruleus: A dark-colored group of noradrenergic cell bodies located in the pons near the rostral end of the floor of the fourth ventricle; involved in
14、 arousal and vigilance.,17,Copyright 2004 Allyn and Bacon,18,Copyright 2004 Allyn and Bacon,19,Physiological Mechanisms of Sleep and Waking Neural Control of ArousalSerotonin (5-HT): Appears to play a role in activating behavior; almost all of the brains serotonergic neurons are found in the raphe n
15、ucleus, located in the medullary and pontine regions of the brain. Raphe nucleus: A group of nuclei located in the reticular formation of the medulla, pons, and midbrain, situated along the midline; contain serotonergic neurons.,20,Copyright 2004 Allyn and Bacon,21,Copyright 2004 Allyn and Bacon,22,
16、Physiological Mechanisms of Sleep and Waking Neural Control of ArousalHistamine: A neurotransmitter implicated in control of wakefulness and arousal; a compound synthesized from histidine, an amino acid. Tuberomammillary nucleus: A nucleus in the ventral posterior hypothalamus, just rostral to the m
17、ammillary bodies; contains histaminergic neurons involved in cortical activation and behavioral arousal.,23,Physiological Mechanisms of Sleep and Waking Neural Control of ArousalHypocretin: A peptide also known as orexin, produced by neurons whose cell bodies are located in the hypothalamus; their d
18、estruction causes narcolepsy.,24,Physiological Mechanisms of Sleep and Waking Neural Control of Slow-Wave SleepVentrolateral preoptic area (VLPA): A group of GABAergic neurons in the preoptic area whose activity suppresses alertness and behavioral arousal and promotes sleep.Destruction of this area
19、has been reporter to result in total insomnia, coma, and eventual death in rats.,25,Copyright 2004 Allyn and Bacon,26,Copyright 2004 Allyn and Bacon,27,Copyright 2004 Allyn and Bacon,28,Physiological Mechanisms of Sleep and Waking Neural Control of REM sleep PGO wave (Pontine, Geniculate, Occipital)
20、: Bursts of phasic electrical activity originating in the pons, followed by activity in the lateral geniculate nucleus and visual cortex, a characteristic of REM sleep.,29,Copyright 2004 Allyn and Bacon,30,Copyright 2004 Allyn and Bacon,31,Copyright 2004 Allyn and Bacon,32,Physiological Mechanisms o
21、f Sleep and Waking The Executive Mechanism Peribrachial area: The region around the brachium conjunctivum, located in the dorsolateral pons; contains acetylcholinergic neurons involved in the initiation of REM sleep. Carbachol: A drug that stimulates acetylcholine receptors.,33,Physiological Mechani
22、sms of Sleep and Waking The Executive Mechanism Medial pontine reticular formation (MPRF): A region that contains neurons involved in the initiation of REM sleep; activated by acetylcholinergic neurons of the peribrachial area. Magnocellular nucleus: A nucleus in the medulla; involved in the atonia
23、(muscular paralysis) that accompanies REM sleep.,34,Biological Clocks Circadian Rhythms and ZeitgebersCircadian rhythm: A daily rhythmical change in behavior or physiological process. Zeitgebers: A stimulus (usually the light of dawn) that resets the biological clock responsible for circadian rhythm
24、s.,35,Biological Clocks The Suprachiasmatic NucleusSuprachiasmatic nucleus: A nucleus situated atop the optic chiasm. It contains a biological clock responsible for organizing many of the bodys circadian rhythms. Melanopsin: A photopigment present in ganglion cells in the retina whose axons transmit
25、 information to the SCN, the thalamus, and the olivary pretectal nucleus.,36,Biological Clocks The Suprachiasmatic NucleusIntergeniculate leaflet (IGL): A part of the lateral geniculate nucleus that receives information from the retina and projects to the SCN; terminals release neuropeptide Y at the
26、 SCN.,37,Copyright 2004 Allyn and Bacon,38,Biological Clocks Control of Seasonal RhythmsFamilial advanced sleep phase syndrome: A 4-hour advance in rhythms of sleep and temperature cycles, caused by mutation of a gene involved in the rhythmicity of neurons of the SCN.Pineal gland: A gland attached to the dorsal tectum; produces melatonin and plays a role in circadian and seasonal rhythms.,39,Biological Clocks Control of Seasonal RhythmsMelatonin: A hormone secreted during the night by the pineal body; plays a role in circadian and seasonal rhythms.,
