1、 2 2 2 , 2 , 2 ; 2 ; ; ; ; (1990-) , , , , , : , E-mail: Research progress for the effect of blood pressure management on stroke recurrence in patients with type 2 diabetes Meng Meimei Huang Xiaoxin Lou Qingqing Yao Jinlan Keyword Blood pressure management; Type 2 Diabetes; Stroke; Hypertention; Nur
2、sing; (Stroke) , , 1-2 2 , 3-4 2 , 2 4 , , 2 , 2 , 2 , 1 2 , , (American diabetes association, ADA) 2013 ADA 5, , , , 6 , , , 40% (UKPDS) 7 2 , 2 44%, 8 , 2 , 2 2 2 , , , 2 (Chinese diabetes society, CDS) 9 2010 , / 2011 10-11 , 2 80mmHg 80mmHg , (RR=2.4, 95%CI 1.384.27, P=0.002 1) ; 140mmHg , ; 130
3、139mmHg 130mmHg (RR=1.1, 95%CI 0.482.52) , : 140149mmHg 150159mmHg 130mmHg , (RR=2.4;2.6;2.5) , ACCORD PROFESS 17-18 , 140mmHg , 120mmHg 2 , 2 , 49 518 19 , 120mmHg 140150mmHg 130140mmHg , , 120140mmHg 20 330 20 , 120mmHg 140150mmHg 2 (2013 ) 21 , 2 140mmHg, 80mmHg , , 2 , , , 3 2 , , , , 2 , , 2 ,
4、, 6 , 22 3.1 , 15 , , 3.1.1 2 , , (5g/d) ( 2 000mg/d) (200mg) , ( ) , BMI 18.524.9kg/m, 88cm, 102cm; 3.1.2 , 2 , , 47d, 150min , 3.2 , Eguchi 23 4 310 , 24.5% 2 , : 140/90mmHg 130/80mmHg , 135/84mmHg 129/78mmHg , , 2014 24 125/75mmHg , , 25: , 30min, ; 2h , 130/85mmHg15, , , 3.3 , , 2015 (ADA) 26 ,
5、: (Angiotensin converting enzyme inhibitor, ACEI) (Angiotensin receptor blockers, ARB) ACEI ARB 2016 25 , 2 , ACEI ARB, ACEI ADVANCE 27 , ACEI , ACEI ARB ; , , , (Empagliflozin) - 2 , 2 , 28-29 , 2 , , , , , ; 2 , , 2 , , 1Kernan W N, Ovbiagele B, Black H R, et al.Guidelines for the prevention of st
6、roke in patients with stroke and transient ischemic attack:A guideline for healthcare professionals from the American Heart Association/American Stroke AssociationJ.Stroke, 2014, 45 (7) :2160-2236. 2 . J. , 2013, 21 (2) :112-115. 3American Diabetes Association.Standards of medical care in diabetes-2
7、015abridged for primary care providersJ.Clin Diabetes, 2015, 33 (2) :97-111. 4Horr S, Nissen S.Managing hypertension in type 2diabetes mellitusJ.Best Pract Res Clin Endocrinol Metab, 2016, 30 (3) :445-454. 5American Diabetes Association.Standards of medical care in diabetes:2013J.Diabetes Care, 2013
8、, 36 (Suppl1) :S11-66. 6Progress Collaborative Group.Randomized trial of a perindopril-based blood-pressure-lowering regimen among 6105individuals with previous stroke or transient ischemic attackJ.Lancet, 2001, 358:1033-1041. 7UK Prospective Diabetes Study Group.Tight blood pressure control and ris
9、k of macrovascular and microvascular complications in type 2diabetes:UKPDS 38J.B M J, 1998, 317:703-713. 8Laakso M.Benefits of strict glucose and blood pressure control in type 2 diabetes-lessons from the uk prospective diabetes studyJ.Circulation, 1999, 99 (4) :461-462. 9 . 2 (2010 ) J. , 2012, 4 (
10、1) :81-117. 10Goldstein L B, Bushnell C D, Adams R J, et al.Guidelines for the primary prevention of stroke:A guideline for healthcare professionals from the American heart association/American stoke associationJ.Stroke, 2011, 42 (2) :517-584. 11 . 2010J. , 2011, 44 (4) :282-288. 12Giuseppe Mancia,
11、Robert Fagard, Krzysztof Narkiewicz, et al.2013ESH/ESC Guidelines for themanagement of arterial hypertension the task force for the management ofarterial hypertension of the European society ofHypertension (ESH) and of the European Society of CardiologyJ.Journal of Hypertension, 2013, 31:1281-1357.
12、13Lars H Lindholm, Bo Carlberg.The new Japanese society of hypertension guidelines for the management of hypertension (JSH 2014) :A giant undertakingJ.Hypertension Research, 2014, 37:391-392. 14American Diabetes Association.Standards of medical care in diabetes-2015J.Diabetes Care, 2015, 38 (Suppl1)
13、 :S49-S51. 15Shelagh B Coutts, Theodore H Wein, M Patrice Lindsay, et al.Canadian stroke best practice recommendations:Secondary prevention of stroke guidelines, update 2014J.Int J Stroke, 2015, 10 (3) :282-291. 16Gary Friday, Milton Alter, Sue-Min Lai.Control of hypertension and risk of stroke recu
14、rrenceJ.Stroke, 2002, 33 (11) :2652-2657. 17Accord Study Group, Cushman W C, Evans G W, Byington R P, et al.Effects of intensive blood-pressure control in type 2diabetes mellitusJ.N Engl J Med, 2010, 362:1575-1585. 18Ovbiagele B, Diener H C, Yusuf S, et al.Profess Investigators:Level of systolic blo
15、od pressure within the normal range and risk of recurrent strokeJ.JAMA, 2011, 306:2137-2144. 19Carlos A, Feldstein.Lowering blood pressure to prevent stroke recurrence:A systematic review of long-term randomized trialsJ.J Am Soc Hypertens, 2014, 8 (7) :503-513. 20Bruce Ovbiagele, Hans-Christophe Die
16、ner, Salim Yusuf, et al.Level of systolic blood pressure within the normal range and risk of recurrent strokeJ.JAMA, 2011, 306 (19) :2137-2144. 21 . 2 (2013 ) J. , 2014, 22 (8) :2-42. 22Bruce Ovbiagele.Low-Normal systolic blood pressure and secondary stroke riskJ.Journal of Stroke and Cerebrovascula
17、r Diseases, 2013, 22 (5) :633-638. 23Eguchi K, Hoshide S, Komori T, et al.A new proposal for the target value for home BP in type 2diabetes patients:The JHOP studyJ.Am J Hypertens, 2015, 28 (8) :971-979. 24Shimamoto K, Ando K, Fujita T, et al.The Japanese society of hy-pertension guidelines for the
18、management of hypertension (JSH2014) J.Hypertens Res, 2014, 37 (4) :253-390. 25Alexander A Leung, Kara Nerenberg, Stella S Daskalopoulou, et guidelines for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertensionJ.Canadian Journal of Cardiology, 2016, 32:5
19、69-588. 26American diabetes association.Standards of medical care in diabetes-2015abridged for primary care providersJ.Diabetes Care, 2015, 38 (Suppl 1) :S1-S94. 27Patel A, MacMahon S, Chalmers J, et al.Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular o
20、utcomes in patients with type 2diabetes mellitus (the ADVANCE trial) :A randomised controlled trialJ.Lancet, 2007, 370:829-840. 28Tikkanen I, Narko K, Zeller C, et al.Empagliflozin reduces blood pressure in patients with type 2diabetes and hypertensionJ.Diabetes Care, 2015, 38:420-428. 29Zinman B, Wanner C, Lachin J M, et al.Empagliflozin, cardiovascular outcomes, and mortality in type 2diabetesJ.N Engl J Med, 2015, 373 (22) :2117-2128.