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血压管理对2型糖尿病患者脑卒中再复发影响的研究进展.doc

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1、 2 2 2 , 2 , 2 ; 2 ; ; ; ; (1990-) , , , , , : , E-mail: Research progress for the effect of blood pressure management on stroke recurrence in patients with type 2 diabetes Meng Meimei Huang Xiaoxin Lou Qingqing Yao Jinlan Keyword Blood pressure management; Type 2 Diabetes; Stroke; Hypertention; Nur

2、sing; (Stroke) , , 1-2 2 , 3-4 2 , 2 4 , , 2 , 2 , 2 , 1 2 , , (American diabetes association, ADA) 2013 ADA 5, , , , 6 , , , 40% (UKPDS) 7 2 , 2 44%, 8 , 2 , 2 2 2 , , , 2 (Chinese diabetes society, CDS) 9 2010 , / 2011 10-11 , 2 80mmHg 80mmHg , (RR=2.4, 95%CI 1.384.27, P=0.002 1) ; 140mmHg , ; 130

3、139mmHg 130mmHg (RR=1.1, 95%CI 0.482.52) , : 140149mmHg 150159mmHg 130mmHg , (RR=2.4;2.6;2.5) , ACCORD PROFESS 17-18 , 140mmHg , 120mmHg 2 , 2 , 49 518 19 , 120mmHg 140150mmHg 130140mmHg , , 120140mmHg 20 330 20 , 120mmHg 140150mmHg 2 (2013 ) 21 , 2 140mmHg, 80mmHg , , 2 , , , 3 2 , , , , 2 , , 2 ,

4、, 6 , 22 3.1 , 15 , , 3.1.1 2 , , (5g/d) ( 2 000mg/d) (200mg) , ( ) , BMI 18.524.9kg/m, 88cm, 102cm; 3.1.2 , 2 , , 47d, 150min , 3.2 , Eguchi 23 4 310 , 24.5% 2 , : 140/90mmHg 130/80mmHg , 135/84mmHg 129/78mmHg , , 2014 24 125/75mmHg , , 25: , 30min, ; 2h , 130/85mmHg15, , , 3.3 , , 2015 (ADA) 26 ,

5、: (Angiotensin converting enzyme inhibitor, ACEI) (Angiotensin receptor blockers, ARB) ACEI ARB 2016 25 , 2 , ACEI ARB, ACEI ADVANCE 27 , ACEI , ACEI ARB ; , , , (Empagliflozin) - 2 , 2 , 28-29 , 2 , , , , , ; 2 , , 2 , , 1Kernan W N, Ovbiagele B, Black H R, et al.Guidelines for the prevention of st

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20、utcomes in patients with type 2diabetes mellitus (the ADVANCE trial) :A randomised controlled trialJ.Lancet, 2007, 370:829-840. 28Tikkanen I, Narko K, Zeller C, et al.Empagliflozin reduces blood pressure in patients with type 2diabetes and hypertensionJ.Diabetes Care, 2015, 38:420-428. 29Zinman B, Wanner C, Lachin J M, et al.Empagliflozin, cardiovascular outcomes, and mortality in type 2diabetesJ.N Engl J Med, 2015, 373 (22) :2117-2128.

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