1、 50 : : 100 , 50 A , , 60d PASI VEGF IL-21 : PASI (P0.05) , 1.2 3; ; 1860 ; ; A ; 3 A ; 1.3 ; 2 ; 60 ; ; ; 3 A 1.4 PASI 3 :PASI 10 20% 100 , 2 4 8 1 , , , 1 (Vascular Endothelial Growth Factor, VEGF) IL-21 25 VEGF IL-21 , 1.5 PASI , , , (D) (I) (E) , , , PASI 072 = ( - ) / 60%89%, 30%59%, 0.05) ; VE
2、GF IL-21 , (P0.05) ; (P0.05) 3 4 3 VEGF 4 IL-21 3 , 1 , , , , , , , , , , 4 , , , ; , , , , ; ; , , , , VEGF 5 VEGF , VEGF VEGF 6, , VEGF , , VEGF , ; , , , ; , , T CD4T , Th , IL-21 CD4T , IL-21 VEGF (P0.05) , VEGF IL-21 , , 1 . M.3 . : , 2001:1011-1012. 2 , . J. , 2013, 12 (3) :556-557. 3 . M. : ,
3、 2002:299. 4 , . J. , 2007, 25 (12) :2 627-2 628. 5Detmar M, Brown L F, Claffey K P, et al.Overexpression of vascular perme ability factor vascularendothelial growth factor andits recep-torsin psoriasisJ.J Exp Med, 1994 (180) :1141-1146. 6Claffey KP, Robinson GS.Regulation of VEGF/VPF expression in tumor cells:consequences for tumor growth and metastasisJ.Canc-er Metastasis Rev, 1996, 15 (2) :165.
