1、17,+DA Anti-Ach Stimulate D-R,Fast,L-aminoacid transporter on BBB?,D1-3, which is important for PD?,二、拟多巴胺类药物 LEVODOPA,Aromatic L-amino acid decarboxylase（AADC),Active,Into Blood,Dopmine,BBBActive,CNS,Dopamine ( inside or outside of C?),帕金宁, 心宁美,D2 is responsible for PD,Beta antagonist,Long Periods,
2、Dyskinesia: A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements, similar to tics or chorea .,为什么初期治疗没有？,2. On-off response,3. Adverse mental effects,Drug Interactions,Vitamin B6:A water-soluble vitamin and is part of the vi
3、tamin B complex group. Pyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.,Selegiline: I
4、nhibitor of MAO-B in CNSNitecapone: Inhibitor of COMT outside of CNSTocapone: Inhibitor of COMT of whole body,AD?,4. Agents to increase the release of DA,三、抗胆碱药 Cholinoceptor antagonists,BenzhexolBenzatropine,Atropine Scopolamine?,1.甲磺酸培高利特：美韩发现心血管不良反应， 中国如何撤药？2.美多巴，心宁美的组方原理？3.为什么美多巴之类用到最后，还是无效？4.开关现象？如何调整给药方案？5.Levodopa是否可用于精神疾病患者？ 闭角型青光眼患者？ 消化性溃疡患者?,谢谢观看/欢迎下载,BY FAITH I MEAN A VISION OF GOOD ONE CHERISHES AND THE ENTHUSIASM THAT PUSHES ONE TO SEEK ITS FULFILLMENT REGARDLESS OF OBSTACLES. BY FAITH I BY FAITH,
