1、ZHONGYIZAZHI1955M175092009M917ISSN 1001-1668CN11-2166/ R5SED05D0( 100029guJ4|)SDS( 100700g=2l16|)x280zKFE40SI DI ( 100700g=2l16|): ( 010) 64013162( 010) 640144113040/ 3045.: ( 010) 64050201E-mail: jtcmcn 188. comD ( 100700g=2l16|): ( 010) 64035632: http: / / www. jtcm. net. cnD( 100700g=2l16|): ( 01
2、0) 84001808, 64035632Y().lK: 13911511969B( 100077guE69|)S=?S?SS=m9( 100044399Q)|M140S|2-698D ( 100700g=2l16|): ( 010) 640144113036N9. 80,M117. 60V30204|Q)D3s0SX李梢( 773)lllllh0Z0O王阶熊兴江( 777)lllllllloDi9pDU杨忻孟庆刚( 781)DVMp郭仁真李浩( 784)llllMh任晓芳杨璞叶( 786)CusE)P李卫兴汪涛( 787)lllyl87吴夏勃( 789)llllllllllllXK0F?25
3、崔旭红张春明( 791)llllEaEh8刘爱民( 792)5h1L0房 恭周雪忠刘保延等( 794)lllllllllllllJM*?4054赵永华刘煜德关莹等( 798)lllllllllllll/,R,CD4+ T%M1yVrY王海隆冯兴华姜泉等( 801)llll60杨德明( 820)lllz/| 张小军( 820)llllllllzLUrD李志龙( 820)h)?aa陈五一整理( 821)%)kyN李建生张艳霞周红艳等( 822)llllllD7ABya5+程峥青杜程昊张云云等( 826)Z0479vyc#FY付于夏天颜贤忠等( 831)llllllUhvM#YZT李佃贵戎士玲王凤丽
4、等( 835)llbAmZ%M1VrY庆慧黄霞刘惠霞等( 839)D0?ZZ4A04白晓菊( 842)ZE|hLN齐建兴李永新( 844)8YEhaC王莹莹杨金生( 847)Dfe7hX吕小亮余尚贞石青( 850)5?8Uh焦扬刘锡瞳( 853)5DOiI吴沛田( 855)ll8Oh黄成汉胡献国( 855)ll|Eo陶春祥何占德( 855)lllllllllll003S%h文双纶( 856)Euev+$w5吴中平张瑾柯雪帆( 857)lllllllVovh,EBp0孙利民( 858)l04r1李文婧( 859)llllllpBoF|p赵厚睿( 859)llllll0D/苏建春于云华塔依尔江等(
5、 860)K/02M 1h40lll唐芳唐欢黄昆( 780)llllllll!|3F?g855吴婧日韦( 788)lllllllllllllllO*Fe62封一平肖慧( 807)lllllllllllfa5Y850马欢杰( 841)lllllllllllllllOl%Wl5854卢国莲王胜( 852)lllllllllll/AEYbS:150康日新高莉高敬利等( 854)3( 861)lllllllllllllllll( 783, 785, 797, 800, 813, 825, 830, 849)llllfK( 803)llllllllllllllll( 834)llllllllllllll
6、llllJOURNAL OF TRADITIONAL CHINESE MEDICINEMonthlyEstablished in January 1955Volume 50, Number 9Sep. 17, 2009ISSN 1001-1668 CN11-2166/RResponsible InstitutionState Administration of TraditionalChinese M edicineSponsorChina Association of Chinese Medicine( 4A, Yinghualu, Chaoyang District,Beijing, 10
7、0029)China Academy of Chinese MedicalSciences( 16, Nanxiaojie, Dongzhimennei, Beijing,100700)HonouredEditor-in ChiefFEI KaiyangEditor-in-ChiefCAO HongxinDirectorLIU GuozhengEdited byEditorial Office of Journal ofTraditional Chinese Medicine( 16, Nanxiaojie, Dongzhimennei, Beijing,100700Tel: ( 010) 6
8、4013162( 010) 64014411-3040/ 3045Fax: ( 010) 64050201E-mail:jtcmcn 188. comPublished byPublishing House of Journal ofTraditional Chinese Medicine( 16, Nanxiaojie, Dongzhimennei, Beijing,100700)Tel: ( 010) 64035632Website: http: / / . cnPrinted byBeijing First Printing House( 69, Majiabulu, Fengtai D
9、istrict, Beijing,100077)Domestic SubscriptionDistributed by Beijing SubscriptionBurear; Order from local post officeCode: 2-698Overseas SubscriptionChina International Book TradingCorporation( P. O. Box 399, Beijing, 100044)Code: M140CONTENTSIN BRIEFStudyon the BasicHerbal Medicinesand Acupointsinth
10、e Therapyof AcupointApplicationfor Winter-Disease-Treated-in-SummerFANG Yigong, ZHOU Xuezhong, LIU Baoyan, etal. (794)lllllllClinical Observation on 40 EarlyPrimaryHypertension PatientsTreated byYinian JiangyaYinZHAO Yonghua, LIU Yude, GUAN Ying, et al. (798)lllllllllEffect of Bushen QiangjiGranule
11、onthe Expression of CD4+ TLymphocyte ApoptosisRelatedGene of Patientswith AnkylosingSpondylitisWANG Hailong, FENG Xinghua, JIANG Quan, et al. (801)llllllClinical Observation onXianhe Qiangxin PillsCombined with Conventional WesternMedicine in Treatment of Heart Failure due toCoronary Heart DiseaseZH
12、U Liyou, YAN Rui, WANG Jianhua, etal. (804)lllllllllClinical Observation onthe Effect of Acupuncture and Point-injection on Bells PalsyCHEN Peng, GE Baohe, LIU Jie, et al. (808)llllllllllllEffect of Different Quantity of Acupuncture Stimulation on Cervical SympatheticDischarge in Ratswith Stress-ind
13、ucedHypertensionZHI Jianmei, WANG Zhaoyang, WANG Li, et al. (811)lllllllEstablishment and Evaluation of Phlegm-heat Syndrome Modelsof BacterialPneumoniaLI Jiansheng, ZHANG Yanxia, ZHOU Hongyan, etal. (822)llllllRisk Factors, Clinical Characteristicsand Prognosisin Ischemic Stroke Patientswith Differ
14、ent Patternsof TCM SyndromeCHENG Zhengqing,DU Chenghao, ZH ANG Yunyun, etal. (826)lllllEffect of Xiongqi Mixture on ExcitatoryAminoAcid and Metabonomics afterCerebral Ischemical Reperfusion Injuryof MCAORatsFU Yu, XIA Tian, YAN Xianzhong, et al. (831)lllllllllllChangesof Gastrointestinal Hormonein D
15、ifferent Stages of Diabetesof Rats andIntervention of Liangrun TongluoRecipeLI Diangui, RONG Shiling, WANG Fengli, etal. (835)llllllllEffectsof QingreQushi Yiqi Formulaonthe Expressionsof the Injured HepatocyteApoptosis Related Proteins in MiceQING Hui, HUANG Xia, LIU Huixia, et al. (839)llllllllluD
16、vuDvD0SDS, 1955M7STo4,Y$#pZ,SD07*a?vaYSE)D0,S,SS/,SS/,nSE,SZb1oDpopDO0P4h,;o53p0,?;o5pao5pD0ZEaT,LVL;o5psP45,0bN,BT5aZE5NaEah)aw&aZEa8aE,VPgKZE,D0aD0,45#=mbuDv(,v167, 96:), 2010M9. 80,M117. 60,S,?|: 2- 698,S|: M140b#: (010)64014411- 3036buDv()1, 1?,S=N:22. 00,hI ,: (010)64014411- 3049bI :g=2l16|,I:
17、100700,: ( 010)64035632b: http: /www. jtcm. net. cnb:SE1S( 30873464, 90709013) ,SES/95( 2006BAI08B05-05)ZT: shaol mail.tsinghua. edu. cn理论探讨D3s0SX李梢(清华大学自动化系清华信息国家实验室生物信息学研究部,北京市海淀区清华园1号, 100084)K1VZ73$,yVoV-3s0-0phZ1O,NB43s0SX,ieb7s3s0SZ48aD05rNaZ4005V?b1oM;3s0S;d3;3D+84O,haZM,ohZpT+b()3$5D0C1o,-|a
18、/aeaa,iaLaZ4a4O3bEM,3$|Z,H9jC1o4:B4V43SW1Es;=Cd=8ZEb4P3$D0C5b11999M 1 ,V3s0457ZbYVM,adhZd=doV-3s0-0pObB4o3s0SpX,3$4Bob1V3s03$1. 1相互作用网络功能3$CD3S?ZMM1bY3/#3ad3Sy?Z,-D3S?3V_d,B1SV3s0?M3bM,8?i?Y3s0,73s0MT#Wa?73,yaRNAa3s0YVQMT7LC+3?b3s0YtMT#d,521W3S1olBboMT?p,M?D 2adD 3 ,#0 4Z,9yaa8DT4V?btD8?a8d+Y),V7;D0
19、4-G,44W1,3$o,4-b1. 2系统生物学研究策略与模式的变革d3BM,d8QX,D84aVo8vp,.Besedovsky 1977M4*=sf(NEI)b7;d8QH=1T=O,?17/,7/D3S5s,4|8b20Wd3S5,aTZE,4S4,i3dd#5Hbd3z(data-driven)1/7Taz(model-driven)17/T,9Lm,YV93VLL!,YVL_L!,V7d8M1?pMbi,YF(yFaFaF)/&V?v?s 5 ,1G9ayZEw=dbyN,3da3y9l39ZE1,iP-K-SBb-V,3s03dy$1VCZT 2 ,c773cD2009M9509
20、Journal of T raditional Chinese Medicine, 2009, Vol. 50,No. 9o1pbd3TM,PV3s03$!CLVbYVM,4oV-3s0-0pO 6,hZ1|z,iB43s0S4$(m)bmhZ1V-3s0-0O,#3s0SUim2V-3s0-02. 1以表型组合为基础研究证候oVpDa85VC,8syVrY7VC+bDohpaDop(1V4bYVhMaaaRay5a85A1(RA)n5V,aDB%h( RA)+1bT?CaDRAZTsAbD4M1,D%hVyIa#4,yN,%h5B,#eaY 7bH,Dop4VW1,YV+VF(F)QbGaS
21、ARS%h5,si?C() 8aZ4S(SARSSaO2)a(SARSq)MM1+sVF 9 ,V7OBSG,i4UVF$,VB3#8=d 10b2. 2表型与基因的全局关联haQ(Vs0b3$n51y4hV43s0W,9-D3S5BbVy1opZTbD5aO,8IVW1bkDB8ZT,VV8?,yBCI-PHER9 11LCVy1br3s0MTdVWM1,Nshy,iLC-Khyb5000XVyFShy,TB?CVy1v+,BFM1V,y3s09 11bB?CQDO,iB43s0SX4,VaF,?8C3s0+?byV3s01,9V3dh,.Yhahb2. 3表型NEI药物多层次网络NEI8a
22、8MTwg, NEI4CDV_8B18CbW80M,VNEIm3$b7;NEI3s0W1#NEIha01Ks,8ZEblBK,2006M4|oQNEIpModNEIpX,YVsaNEIe,#a%y0a*MT,yS=nNEI5odb-NEI 12bN,CIPHERZE?C, NEIVM1y3s0K,vKA 11biBvhZMD,ZNEI3s0MTacy0microRNAeT$,NEIM1%ha0,8y%hV- NEI-0Q 13 ,YVQs?C0%hWohspaoshp+bBTVs0dQhZ14,i4UhZW1VoV-3s0-0pW=1b33s0SX;V,yFd,c774cD2009M9509J
23、ournal of Traditional Chinese Medicine,2009, Vol. 50,No.94B3a3SVr 14bmU,V-3s0-0O$,VQVFaZ4r?,+3$B4o3s0SpX:+3s0MM1b3s0?Z,8CB,dT;?v+,YVBFMMT3s0LC?b/Hqa8C1?1ov,o3s0Sp: +VFM1;?rus,kYil;?sZ4eb1B3s0?kY+,QZ1bH,3s0#Sh3VayY/?3BM,iVYCT,V78C8adilb43s0S4. 1寒证、热证的生物分子网络标志eaD#$,Q8|9ah|bV3Mea3$bn5VeaVF?,yNEIea3s0bY
24、V?s,?Ce3s0?v,3s0%y0?v,*?vsb7Voshpea?+:YVs121eM1%ha38M1%hhys,?C%hhyAs%y0Y,F%hhyAs*YbH,YVs,?Ce3s0S(Scale-free),?LC1GBt1obyN,VoZM1p,|e1oT,N4eaZ4v3r,T?CZ41Te1o,eZ41T1o,oe0ae0pO5B 15b8?+,ea1oF?vsY/Hq: eaVF$;eakYil;?ruseaZ4T+,yN,VjTea3s0SbN,yDop#e8 16 ,Be3s0SM,#eYCT4$b4. 2证候生物分子网络标志与个体化诊疗ohsashpQ%hW=,98C8
25、B5bk|h13s0/1s,iN4D!yVrsay+h3s0LMMAZE 17,ZE9shsashs0$-4Hqb53M1%heOb53a?a5hv%hhV,VD?,534oGMpB4 18,iLMMAZEy533s0bb=?Vu2Devo,Le,=,?ep,?C,e3s0533s0Wi|Y,hibHeSVrus53s0, TNF-Ae1o, TNF-A/eas0?3MT,isY53Va1bT4U,eV?Q53?3a?ZV=,ae0 15b5=%M9$|hM 19 ,yN,BZ,4U,s03$VBea|W1;6BZ,3s0SVBVs0%hoOpob53s0SZ48:3s0S4V43SWy,iV
26、V?=8+,V73$4BVZE,Z4a4O#8,1wTbH9h1aZ1aZ4TD05,bD05rN:3s0S,D05rNVva9F.dVTb3s0S$,?D05rS,sc775cD2009M9509Journal of T raditional Chinese Medicine, 2009, Vol. 50,No. 9D05rSW1#8?,%hZ4SDSW1,V7us%hrrbZ4?p8T:3s0SV,y0s,7syxTH5Mc,Z4Bd 15bxTZ4YV78r$bV3s0S?,VZ4xToCp1Z4sTb7YVs,VI_wZsrFbNy3s0w0FxTZE,V.dZ4?Ci3xTrsF 2
27、0b003$:00OBbV3A,000M1Vs,yN,003$VYV0M13s0Sb1e0- 1594UBb700aZ43=dG,0+9V0a0Fb6Z3s0SX,V3d,|4V43S,iVaVL8_13$TZE,M3=dil,9d3a3QZED04BHVobV,3s0SVZ4aD05rNaZ48Ta003$5,9V44F8d#ZTMbID 1.Ds0V?1.;zI._21WS/ 6?Z M.:SS/ .1999: 442. 2 Barabsi AL. Network medicineiifrom obesity to theodiseasomepJ . N Engl J Med, 2007,
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30、G) and IgA antibody responses and thevalue of clinical presentations in diagnosis of H. pylori infec-tion in patients with precancerous lesionsJ . World J Gas-troenterol, 2003, 9( 4) :755- 758.9Li S, Wang R, Zhang Y, et al. Symptom combinations asso-ciated with outcome and therapeutic effects in a c
31、ohort of cas-es with SARSJ. Am J Chin Med, 2006,34(6): 937- 947. 10.V)D+#SZEJ.D0v,2003, 26(3): 1- 4.11Wu XB, Jiang R, Zhang MQ, et al. Network-based globalinference of human disease genes J. Mol Syst Biol, 2008,4: 189, E1- E11.12Zhuang YL, Li S, Li YD. dbNEI: a specific database forneuro-endocrine-i
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33、se medicine in the context of neuro-en-docrine-immune networkJ . IET Syst Biol, 2007,1( 1) :51- 60.16Kang GL, Li S, Zhang JF. Entropy-based model for inter-preting life systems in traditional Chinese medicine J. EvidBased Complement Alternat Med,2008, 5( 3) :273- 279.17 Li S, Wu LJ, Zhang ZQ. Constr
34、ucting biological networksthrough combined literature mining and microarray analy-sis: a LM MA approachJ . Bioinformatics, 2006, 22( 17) :2143- 2150. 18,.A1VopO8J.D.2002, 43(2):85- 88.19,-.|LZIJ.SD0,2003, 18( 8) :490- 493.20,fao,fp.y0FxTZE.2008M#hS?.#h|:200810239284.4.(l: 2009- 05- 08;: 2009- 07- 07
35、)编辑:黄健c776cD2009M9509Journal of Traditional Chinese Medicine,2009, Vol. 50,No.9:SE$?Z9(o973p9)( 2003CB517103)YT:, 5administration 163. com, 13260399412h0Z0O王阶熊兴江(中国中医科学院广安门医院心内科,北京市宣武区北线阁5号, 100053)K1h0O,Z0Bh0,jZ0PZ4KAYbZ0BNCLybZ0Z01ob1oMh;Z;O;Z1VD0n|OTD+,D5aaS(dBS?S,OTKRpaooh,ph0X1iCDZ,OTvbLD6B7+%h
36、O8iiZ,Z0X)8CDTb1h0Z0=d1h%h5VCa?ZB=G 1,op),op,Yhl 2bOOhaMaEa)Z0,EZ0B8,dE,EdZ,Zd0,B,h?h,Z01,i|hT%hKb=,8,|a#8s,OaAOa#OaOaOaBO#OZE,%hhyahah1,K4MVZ0;Z0FhMH,YC),Ooh0pVbZZ4PZ4,Z4a8bM%hO,%h5Z,|ZdB,Z(0),5Z(0) ,Zb=,8,FOMZ,Z;Z4FhMH,YC,OM0Fh,ZoZ0pVb1V4?C,-OhQop,a|,7O8Z4Z,avC;opYVD4O,yDj7,OiBlaBZaBZ+,7ZZ4%8,Z4Vn
37、,yDj7,MBZ4;0H,-h0,VZ4hh%hd=hM,75Z0,Z48%hVC8MbM17,-,95abyN,jZ0PZ4(8,/)KAYb2h0Z0sY2. 1代表方药选择,sQ,Bh0,aEOopVZa0opBH,chZ(0)chMH,L?|rb1O|V|,O/|VB,OFaa,O|Faa%bAEZ0,5L=idN,VZ0Widil1,yO1Z0zWaFd,|Qv|Q,O|H,18s|bZ0FhMH,Yn*C70H,1?sa,PsAb|ine7mZ4,VZ1a3aaIaaaZ,Zhc777cD2009M9509Journal of T raditional Chinese Medic
38、ine, 2009, Vol. 50,No. 9,5s;?eZ4,VZaIa9Z9MbyN,h0$1TBs?%Z0,y8%Y5MZb2. 2药物配伍选择-04Z,9iVh07Z05bDnZ4,;ZZ0ildvhaDs#0r,5Z0Z4#Z0h1AbB ,vDEV|ahd?,uDZv:o0,H; 1,p,nuuDZv:o0l, 1Ap,9,)3)H, 07A 3bVXn,T 0)H7!,*P0Z4 ? h%,7Z011p?5|,1 F/|;?V| a-01r0;? A?e7opao07ApaoBBp.dcbVB3V,dP-|bInZ y8va/T,yN,Bh/|,Tb(VZ0MbCBa3il,u
39、D7kDZv:o,Ph,cgZ,#FBa3!,#,9b74QT0,;lZp,9,o,|,Fme2A,|,#3aB)|!,PSY$p 3,TZ,*vmve4!|0|?AZBa3idyoPh,cgp%b)+! 3 ?T,I1!?r3aayaV2,o3aan)Hwp 3?lC0yokI.,B?,k,2p 3 ?Vhi7?11bZ#hQw,V5Z0Z4L=?,5NbZ0PZ4j,/5Z?S,XZa1EZaZ5SC,4c,o+|La3XFd*,p 4 ,NrAb3Z0XCZ0X,YNCLybDBN,uevau1vau!$ZvaulZvau$Zvau1vVqHDT,a8M,vh/Z,ZdbZlvhS,hZ
40、0BB1,hnVhbD53*MrHuevu1v,onh,Z40,Z4,g0F%bL,L/S,%bu$vauv,aLZ,T?,grp 5 ,aea21aLHDKv+b1,Dt,E,oDsp,CHeaa!|,Ha,op)A,DObDn,sY,OT,O%hOT?!baO%D?Z,Z,VsDO2D,P?V,okp,ozWp,opboWp|_4,D9NboD.p,/,DoZpaoZpaoZ/p,iZDV,DM,DBZ/bT Ob/eO, Ob/|aa,Bjauevau1c778cD2009M9509Journal of Traditional Chinese Medicine,2009, Vol. 50
41、,No.9vauhHOv#,4?C7MZ8bHCh,CD,nZ5A?|r,V?uev?,?=bEZ8B1oBa,s|MbL,TA(b4Z0Z01o4. 1方证对应Z)D)Z0?p,s%Z4(Z)(a)W+y1,DMa%hT=,Da?ZaA1p=?S,e,Z,Z,ZbC1,M%haMZ0ZT1b0rMV0B%h7S,0M%hM,vC+F7%hQ,M9CZbVD!:VA,u*jvoe/p,DZbuevu1voZpZEa,oh,he?,p0,Ip,Ca,1np(1pp),I,5,5p,H,8,rVZbO-K5OZE,8Oa#Om,yoB,K)ZH1L8ZMY,ZvE;oZBO?,gOUp 7bZBZ
42、$,yN,nZ4Z5AbTZ,VLCOZ,VMM,2:oZh,7hM%,B,h$M7bNVE,hZp 4b4. 2药证对应00PZ4,Z$b00a8Wi+y1,0Z-4pbDB0P1EsT,o0p1buevS,lFhEU,oP7|,1a,F(pLBbW,1,F,-,(pbe,F0b/,v),Fllpb09idXVV,av)0,E)|7v)?yBop?=I?C,u1vYZ4|Z4i0_ 7bV4,ueva8FhCha5EFhsb00rvYb0Mr,%r/Z4bB,IVo?paeap,7uev5o/5pao%paopaohepaoppao0p;B,Vor,6J,m%V,U,3p,7uev5o&8p
43、ao&pao&8paoppaopUI,pao&ppaopbB,Vov,%3,*p,7uev5o/p,53Nvi,gPSo/;E();(|,9V|)p 5bM1,0TT8b0B0$,yN,n0+yG5AbH1n0+8,VM0,nha5,.H,n5InP ,Vc BZ4,IaI)ab5BtP4%hH,YVO|1ZE%VilzrT,VVhd5BMhC9iBt1&bHjoZ0pX,Ooh0pX,Q78M%6,V?Zuev.ZMJ .D0v,1996, 19(1):3- 5. 36.Z4M .Z:ZS/ ,1985: 104,63,118, 158, 22.42.2D M .:SD0 ,1999:362
44、,163.5.D M .:SD0 ,2000:441,554- 555.6W.SMD5EW M .:SD0 , 2001,181.7.17ZM/0KypJ .D, 2007,48(4): 365- 367.(l: 2009- 03- 06;: 2009- 05- 13)编辑:黄健YT:Y, 13608560249限定温度下中药塌渍治疗老年骨关节病40例唐芳唐欢黄昆(贵阳中医学院第二附属医院内四科,贵州省贵阳市飞山街83号, 550003) 1( KOA)Do=pSb.d02ZE,-,1,sKa02,C|T/b151.1一般资料|120( 162)M-65h,s3FbF40(56) ,314,o
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47、.751.00)sb3F1,FrAF(P 0. 01),F(P 0.05)b4)02Z01uD7kvoZZpFhZ,ZZaaAe,aPa0aB|aY,26aaAa=e,+Yb0Z,5,?AKOA1?b8?QB1T,|8442P,VvK9FFa%,FyA,=,FY;v50H,|3#,Fa%Yi9v,Q79F1,Y#0s?,M8sv;8/02,50r?b51,L42j45Wzr,VV|Y5rbID1 Schmacher HR Jr, Klipple JH, Koopman WJ.Primer on therheumatic disease M .10th Edit. Atlant Georgia:
48、 ArthritisFoundation,1993: 206. 2 Lequsne M. Indice of severity and disease activity for os-teoarthritis J . Semin Arthritis Rheum, 1991, 20( 6 Suppl2): 48- 54.编辑:黄健c780cD2009M9509Journal of Traditional Chinese Medicine,2009, Vol. 50,No.9:SE1S( 30873461, 90409005);SES/9( 2006BAI08B05)YT:i, mqgangzy
49、126. com, ( 010) 64286585oDi9pDU杨忻孟庆刚(北京中医药大学基础医学院,北京市朝阳区北三环东路11号,100029)K1DC?C,DviVia4.oip,7DoVipmE+dt,7H,t+dX?C1,CSCmFYaVroipclbVDiioDi9pD+VCmEiioipZm,oipaop$,4DMQ,YVMD+V?b1oMDi9;Vi;MoDi9pD+,D2i,VBSLZEbHca4V+bopDV,7YEB|b4VroipVYVopiboVipDV,s8CDM,aMaopbMV,oip+opTs8Cb#MMVD7b1oDi9pn_u$tZv4:oDi9,iDpbH
50、,|Nih,7|DB4,iN|DdSbL=oDi9pz8CD+iii,D3V,58bC,7bd,lV vM_boDi9pS9v$sbum7.v:oDi9,nbpDh,LI,5V,DI?ZT1bo*,9,775,g?,jn,a,rbpu*voDi9pB,+3B?5*7E.ibiDSVBbDoipbX7,5LlM,8sa8T,VLl,VLla6V,MBQQ6bm7:oDi9,n5,M7?,i,7YpboipQcQ:BQYR?p,YVM1MW|5Ll,|,M,.,VNC,sYR?pb6BQY+y?p,BV,B8V,Dsg,hy,?h,YVn,s8,KE5BVb,oipYR?p+y?p,;pY,858
