1、 4 (j0T张 晨1v (8 ),王笑茹2x ( ,n)( 1.D,067020; 2.D D g 8 S,067020)ms |: R73 DS M : A cI|: 1006-2084 ( 2010) 06-0847-03K1:长期低剂量接触有机磷农药( OPs)为当今社会人群接触农药的最主要方式,绝大多数农药虽经过致癌性评估后投入市场,但长期低剂量接触的致癌作用并无确切结论b许多学者通过回顾性研究分析长期低剂量接触 OPs对人体的损害,多从遗传物质损伤a类激素样作用a免疫系统损伤等方面对其致癌作用进行分析b诸多研究显示,长期低剂量接触OPs与多种癌症发生具有相关性,但亦有部分研究不支持
2、其致癌性b1oM:有机磷农药;长期低剂量;癌症CarcinogenicEffect of Long-term Exposed to Low Doses of Organophosphorus Pesticides ZHANGChen1,WANGXiao-ru2. (1.ChengdeMedicalCollege,Chengde 067020,China; 2.DepartmentofOralMaxillo-facialSurgery, theAffiliatedH ospital of ChengdeMedicalCollege,Chengde 067020, China)Abstract:
3、Long-term exposed to low doses oforganophosphorus pesticides(OPs) is the ma in w ay of peop leexposed to pesticides in today, though th e vastm ajority of the pesticideshave passed the carcinogen icity assess-m en t before pu t on th em arket, there is no final conclu sion of th e carcinogen ic affe
4、ct of long-term exposed tolow doses of organophosphorus. Th e dam ages to th e hum an body of long-term exposed to low doses ofOPs havestud ied retrosp ectively, the carcinogen ic affects w ere search ed m ostly in the aspects of genetic dam age, hor-m on e-like effects, imm un e system dam age. M a
5、ny stud ies have sh ow n that long-term exposed to low doses ofOPs w as associated w ith a variety of hum an cancers, bu t som e stud ies d id not support its carcinogen icity.Key words: Organophosphorus pesticides; Long-term exposed to low doses; C ancer“ -,j0( organophosphorus pesticide,OPs) V ( j
6、0 n, 4 T 8? 3$, A,L;7 4 ( 3a P# J = Y Ga 7 m s jb1 hA U: 4 ( j0 8 *“d a 3?pa? 3T, 0 ?h q M 6 j0(1“bC 4 (OPs? 31“# V ? b1 OPs? 3M1 y L.y T7B %h, y ,L. s Bb y 1“K M,T3 : %L.M, ylMay 9a 8 , V I|%M%; X ?%s 3; P%VC V IyFM, y ay a 8 ,i O a ?%Z vVC ?+ 1b2008 M924 S j0? ir BY 2008 M6 -X V ? j0 , OPs, a ;/ 4
7、 Ui, N V ?0; Ta ;/ V ? 0b j01“,d % ?( non-H odgk incs lym phom a,NH L) KBbB lair 2 7Z 291 j0NHL1“ h, 18 (1 j ) NH L? 3 qd ,MB( RR ) a Abz 102OPs T,l _ % q 8M%qS 4 L.r, F q 8M% q (AvFb 6V 11 OPs V+y Vr,ty yy ,V7? 3, NH La % ?b2. 2 “T = dL.,4, ? MX % 9 1b “ -X?C 70 r,OPs (N , J,Yd+s f ?; OPs ? % f% A,
8、V7 f% b 184100 OPs 3 #50 ( r B, 8A#% f b b f o( IgGaIgAaIgM )c 8A f S;YVH-FJ %3H,9 %s q#O T% f SbTA U,(FIgGaIgAvFM1 A, IgMYA;(F%s qaO AvF,#(OPs 3 8A f% f b f“d ,B OPs V ?iTb3 4 (OPs T ip, s h ,Niy , C ,#OPs4 T# 8V v“hb ID 1 ! .L. M .: S, 2002: 178-181. 2 B lairA, Tarone R, Sandler D, etal. Reliab il
9、ity of reporting on lifes-tyle and agricultural factors by a sam ple of participants in the agr-icu ltu ral health study from Iow a J. Ep id em io logy, 2002, 13 ( 1 ):94-99. 3 Bolognesi C. G enotox icity of pesticides: a rev iew of hum an b iom on -itoring stud ies J. Mu tation Res, 2003, 543( 3 ):
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11、iron H ealth Per-spect, 2006, 114( 12 ): 1838-1842. 6 Sh im YK, M lynarek SP, van W ijngaarden E. Paren tal exposu re topesticides and ch ildhood brain cancer: U. S. A tlantic coast ch ild-#848#D8 2010 M316 6 Medical Recap itu late, M ar 2010, Vo.l 16, No. 6hood b rain cancer study J. Environ H ealt
12、h Perspect, 2009, 117( 6): 1002-1006. 7 Freem an LB, B onner MR, B lair A, et al. C ancer incid ence studycohort exposed to d iazinon J. Am J Ep idem io,l 2005, 162 ( 11 ):1070-1079. 8 Gara-jVrhovac V, Zeljezic D. Cytogenetic mon itoring of croatianpopu lation occupational exposed to a com p lex m i
13、xture of pesticides J. Toxicology, 2001, 165 ( 2 /3): 153-162. 9 K ourak isA, M ou ratidou M, Barbou tiA, etal. Cytogenetic effects ofoccup ationa l exposu rein the peripheral b lood lymphocytes of pest-icide sprayers J. C arcinogenesis, 1996, 17 ( 1): 99-101. 10 z , .j0l %L.Y J.a5 3y0s s,yy # ss 2bs0_0f ?Z HCC4 4,s0_09 “5 Ll |A rb1 s0_ Q1906 M, Enrilich n54_0 Q, B+s8,|0 ?%4 , T0r K+%aF 2 =,7Y%aF 2 ?,V74 r,h QBZEbHCCs0_ , ?%VVr% s8a1oy tSs0,4+sE4,r% s8a1oySs0 e MM1|Y,V7r ? 3aZ#MrT, +s a rAa F 3 bs0_0YV ?%sYV#849#D8 2010 M316 6 M edical Recapitu late, M ar 2010, Vo.l 16, No. 6
