1、39 1 2009 M2 日用化学工业ChinaSurfactantDetergent Cosmetics Vol.39No.1Feb.2009l :2008-05-05; :2008-07-31Te: I )(1979-), o(q), , =,p V,:(020)81252735-8834。新型季铵盐的杀菌活性研究鹿桂乾1,张利萍1,符若文2(1.广州立白企业集团有限公司研发中心,广东 广州 510370;2.中山大学化学与化学工程学院材料科学研究所,广东 广州 510275)K1:41JdY=J o(DMAEMA-BC)、JdY=J(DMAEMA-BB)、JdY=J E=(DMAEMA-
2、DB)JdY=J E B(DMAEMA-HB),Kl ) i(MBC)E ) Ev ) $ o ) )sY V。MBCET?C,DMAEMA-HBDMAEMA-DBMBC12g/mL24g/mL,DMAEMA-BCDMAEMA-BBMBCv50 000 g/mL, )vl :DMAEMA-HBDMAEMA-DBDMAEMA-BCDMAEMA-BB。YV ) E41 ), :DMAEMA-DBDMAEMA-BCDMAEMA-HBDMAEMA-BB。/ ZE kTs1 yYV ) E ),11,1 j ? 1。1oM:1;Jd =JY; )ms |:TQ423.12 DS M :A cI|:100
3、1-1803(2009)01-0025-04StudyofbactericidalactivityofnewquaternaryammoniumsaltsLUGui-qian1,ZHANGLi-ping1,FURuo-wen2(1.ResearchDevelopmentCenter,GuangzhouLibyEnterpriseGroupCo.,Ltd.,Guangzhou 510370,China;2.MaterialsScienceInstitute,SchoolofChemistryandChemicalEngineering,SunYat-senUniversity,Guangzhou
4、 510275,China)Abstract:Bactericidalactivityoffournewquaternaryammoniumsalts(QAS),dimethylaminoethylmethacryloylbenzylammoniumchloride(DMAEMA-BC), dimethylaminoethylmethacryloylbutylammoniumbromide(DMAEMA-BB), dimethylaminoethylmethacryloyldodecylammoniumbromide(DMAEMA-DB),dimethylaminoethylmethacryl
5、oylhexadecylammoniumbromide(DMAEMA-HB), wereevaluatedbydeterminingminimumbactericidalconcentration(MBC)valuesandinhibitoryzonediametersagainstE.coliandS.aureus.ItwasfoundthattheMBCvaluesofDMAEMA-HBandDMAEMA-DBwere12 g/mL24g/mL.However,theMBCvaluesofDMAEMA-BCandDMAEMA-BBwerehigherthan50 000g/mL.Theor
6、derofantibacterialactivityoffourquaternaryammoniumsaltsis:DMAEMA-HBDMAEMA-DBDMAEMA-BCDMAEMA-BB.Theorderofantibacterialactivityoffourquaternaryammoniumsaltsbyinhibitoryzonediametersis:DMAEMA-DBDMAEMA-BCDMAEMA-HBDMAEMA-BB.Themainreasonforthediferencebetweenthetwomethodsisthattheantibacterialactivityme
7、asuredbyinhibitoryzonediametersarerelatednotonlytothestructureofQAS,butalsotothedifusivityofQASonsolidagar.Keywords:quaternaryammoniumsalts;dimethylaminoethylmethacrylate;bactericidalactivity21 W ,S= r B 3i m j。% )1 sd99.0%, L i1; _= )、= _ )、 o), (sB,50 000 50 000 24 12 $ o )50 000 50 000 12 12V1 V,
8、5 v ) $o ), DMAEMA-BCDMAEMA-BBMBC,v50 000 g/mL,V 1% ) ? 。DMAEMA-BCT S 7T .B, V ?y v ) )A i 。261 I ):1 ) 7?1N0 9F,18 )99F。 |sY E= E BH, % )MBC12 g/mL24 g/mL,V 1 ) ?, ) ? GQDMAEMA-BBDMAEMA-BCDMAEMA-BCDMAEMA-HBDMAEMA-BB。 F ) kZE,MBCE F )rT )9E F )rT B。 ,YV )E41 F ) ZETi B,+Y 1DMAEMA-BCDMAEMA-HBVC F ) ?
9、 。CCy V ? 0 F)4 ( )4,1 j ? ,% )(,BHW = 3 ) vl,Moon 13cN d ) H9?C C。DMAEMA-BCs0 l,yN j ? 1 .C 3M.: S, 2002:50-141. 12 EL-NEWEHYMH.BiologicalyactivepolymersV.Synthesisandan-timicrobialactivityofmodifiedpoly(glycidylmethacrylate-co-2-hydroxyethylmethacrylate)derivativeswithquaternaryammoniumandphosphoniumsaltsJ.JPolymSci:PartA:PolymChem, 2002, 40:2384-2392. 13 MOONWS, CHUNGKH,SEOLDJ.Antimicrobialefectofmono-mersandpolymerswithazolemoietiesJ.JAppliPolymSci, 2003(90):2933-2943.28
