1、. .Word 完美格式= 臭氧大自血疗法介绍及开展状况Introduction of Ozone Major Autohemotherapy and Its Development一、 国外开展的情况 Development Condition Abroad臭氧作为一种新兴的治疗手段在欧美已经越来越多的被医生们引起重视，在德国、西班牙医生们采用臭氧自血回输疗法治疗急性期中风患者，使患者致残率大大降低。在意大利许多医院和医生们用于急性椎间盘突出的治疗，取得了意想不到的效果。在古巴、俄罗斯医生们用臭氧水、臭氧油治疗烧、烫伤、糖尿病足，都获得巨大成功。世界臭氧协会、欧洲臭氧协会以及各个国家的臭氧协
2、会纷纷成立，世界臭氧协会分会中国臭氧协会于 2008 年 9 月 5 日成立。中国臭氧协会主席由南方医科大学附属南方医院何晓峰教授担任，与臭氧相关的学科，康复科、骨科、神经内科、传染科、烧伤科、皮肤科的专家教授参与此次大会，讨论交流这种新兴的十分有医学价值的诊疗手段。As a newly emerging treatment method, medical ozone therapy has been more and more brought to a forefront by doctors in Europe and America. Ozone auto blood transfusi
3、on therapy is adopted in treatment of acute phase stroke by doctors in Germany and Spain, which largely decreases patients disability rate. Many hospitals and doctors in Italy adopt ozone therapy in treating acute protrusion of intervertebral disc and it has achieved unexpected good results. In Cuba
4、 and Russia, doctors has achieved great success in burn and diabetic foot treatment with ozonized water and ozonized oil. International Ozone Association (IOA), European Ozone Association as well as other ozone associations in different countries are gradually established. The China Ozone Associatio
5、n, branch of International Ozone Association, is set up in Sept 5th, 2008. Directed by Professor Xiaofeng He from Nanfang Hospital, China Ozone Association attracts experts and professors from ozone application related departments, such as rehabilitation, orthopedics, neurology, infectious disease,
6、burn, dermatology. This rising treatment is of great medical value. .Word 完美格式在这而后,三氧医学逐步从单一治疗椎间盘突出症发展到治疗骨科、肝病科、心脑血管科、烫伤科、糖尿病内分泌科、肿瘤科等临床科室的应用，三氧治疗也从微创介入向三氧大自血治疗的全面发展，中国科学院北京转化研究院（航空总医院）的安建雄教授在三氧自体血的规范化治疗做出了重要贡献。在国内三氧学术界逐渐形成了“ 南有何晓峰、北有安建雄” 的格局。Thereafter, the application of ozone therapy has graduall
7、y developed from solely treatment of intervertebral disc protrusion to clinical treatments in departments of orthopaedics, hepatopathy, cardiovascular, burn, diabetes, endocrinology as well as oncology. Ozone therapy has developed from interventional therapy to major autohemotherapy. In the aspect o
8、f standardized treatment of ozone autohemotherapy, professor Jianxiong AN from Aviation General Hospital of China Medical University, Beijing Institute of Translational Medicine, Chinese Academy of Sciences, makes great contribution. A well-known pattern of “Xiaofeng HE from South, Jianxiong AN” is
9、gradually formed in China ozone academic world.二、医用价值 Medical Value臭氧自血回输及其它疗法可应用于：Ozone autohemotherapy and other therapies are applicable in:1 脑中风。包括出血性脑中风和缺血性脑中风。通过治疗能明显改善患者急性期脑水肿。同以往常规的甘露醇治疗相比具有时间短、见效快的特点。同样也可用于脑膜炎、周围神经病。另外，对于康复期的患者可以非常好的改善其肢体功能，提高患者的生活质量。Cerebral apoplexy: hemorrhagic stroke an
10、d ischemic stroke.Acute phase of cerebral edema can be obviously improved through treatment. Compare with regular mannitol treatment, the ozone therapy is efficient within short time. This treatment can also be applied in treatment of meningitis and peripheral neuropathy. Besides, the ozone therapy
11、can improve limb functions and life quality for the patients who are in rehabilitation. .Word 完美格式2 高脂血症。国内外观察结果显示，治疗显效时间和有效率均明显优于他汀类药物，且没有任何副作用。Hyperlipidaemia (HLP)According to observations from domestic and abroad, the treatment effectual time and efficiency are obviously better than statins with
12、out any side effects.3 糖尿病。可以减少降糖药物治疗，对于糖尿病引起的眼病、糖尿病足有很好的疗效。Diabetes mellitusOzone therapy helps reduce application of hypoglycemic agents and has good results on eye diseases and diabetic foot caused by diabetes.4 肝炎病。对于病毒性肝炎的治疗，疗效相当或弱优于干扰素、拉米夫定等抗病毒药物，但没有抗病毒药物的副作用，且费用较低。对急性肝炎的临床治疗，臭氧有好的退黄疸、降低转氨酶作用。
13、对于酒精性肝炎、药物肝炎等均可有明显的疗效。HepatitisThe therapeutic effects of viral hepatitis equals to or slightly better than antiviral drugs such as interferon and lamivudine without any side effects. The ozone treatment is cost effective. In clinical treatment of acute hepatitis, the ozone therapy has a good curati
14、ve effect in jaundice and aminotransferase reducing. Whats more, the curative result in alcoholic hepatitis and drug hepatitis treatment is clear. 5 脑外科手术脑水肿，疗效显著。Effective treatment in brain surgery of cerebral edema6 外科手术创伤部位。用臭氧水进行常规冲洗能明显促进刀口愈合。最令人可喜的是，伤口留下的疤痕非常轻。Surgical traumaRegular washing wi
15、th ozonized water can clearly promote the healing of the wound. What is exciting is the left scar is not obvious. 7 疼痛介入科。应用介入方式采取点位直接疗法治疗腰间盘、类风湿性关节. .Word 完美格式炎、带状疱疹技术已经非常成熟并取得了非常好的疗效，很多医院专家老师专程去南方医科大学附属南方医院及首都医科大学附属宣武医院学习和交流这项技术。Pain and Intervention Therapy Department Direct point treatment techn
16、ology is adopted in treating lumbar disc herniation, rheumatoid arthritis and herpes zoster. Many medical school experts pay a special visit to Nanfang Hospital and Xuanwu Hospital for study and technology exchanges.8 皮肤科。应用臭氧自血回输疗法和臭氧水冲洗对例如带状疱疹、湿疹和一些真菌感染有奇效。Dermatological DepartmentWashing the skin
17、 infected by herpes zoster, eczema or fungus with ozonized water or ozone autohemotherapy has a miraculous effect.9 肿瘤科。由于臭氧能诱导人体产生多种细胞因子，如肿瘤坏死因子等，所以国外很多医疗机构将臭氧治疗作为抗肿瘤的一种辅助疗法，减轻放化疗患者的疼痛感，提升患者自身免疫力，并取得可喜效果。Oncology DepartmentOzone therapy serves as an adjuvant treatment in antineoplastic therapy to r
18、educe patients pain feeling and improve their immunity in many foreign medical institutes since the ozone induces human body to produce multiple cytokines, such as tumor necrosis factor.另外，目前国际上已经承认的一种新的疾病叫做慢性疲劳综合症，简称CFS。白领阶层、相关工作人员、家庭主妇多发。目前唯一有效的办法即是臭氧自血回输疗法。病人经过一个疗程（10 次）的治疗，症状消失，效果非常明显。In additio
19、n, a new disease, which is called Chronic Fatigue Syndrome (CFS), is acknowledged in the world. It mostly occurs to white-collars, office workers and housewives. At present, the only effective way for CFS is Ozone Autohemotherapy. After a courses treatment (10 times), the symptoms disappear with cle
20、ar effects. . .Word 完美格式三、臭氧大自血疗法简介 Brief Introduction of Ozone Autohemotherapy 什么是臭氧大自血疗法 What is Ozone Autohemotherapy?臭氧大自血疗法疗法是将 50-150ml 的自体血与适量抗凝剂和等量的治疗浓度的臭氧混合再回输入体内（整个过程大约需时 8-10min） ，从而产生治疗作用的臭氧治疗方法。Ozone Autohemotherapy refers to a treatment method that combines 50-150ml blood drawn from hu
21、man body with equivalent ozone in therapeutic concentration and appropriate amount anticoagulant, and transfusing into human body (the whole process takes 8-10 mins). 臭氧的治疗作用 Therapeutic Effects of Ozone therapy1.强氧化作用 Strong oxidation2.促进血液循环作用 Promote blood circulation3.促进含氧血红蛋白向组织释放氧气从而提高氧代谢水平 Ac
22、celerate hemoglobin release oxygen into tissues and improve oxygen metabolism. 4.免疫刺激及平衡作用 Immunostimulation and balancing effect5.广谱抗菌作用 Broad-spectrum antibacterial6.清除自由基作用 Free radicals eradicating 7.清除肿瘤细胞 Eliminating tumor cells（一）臭氧大自血疗法适应症 Indications for Ozone Autohemotherapy1、慢性缺血性疾病 Chron
23、ic ischemic disease动脉循环性疾病主要由于动脉粥样硬化引起的各个器官的疾病。Arterial circulation disorders: various organic disease caused by atherosclerosis. 脑动脉粥样硬化引起的缺血性脑病：TIA、脑梗塞、脑栓塞Ischemic encephalopathy caused by cerebral atherosclerosis: TIA, cerebral infarction, brain embolism.心脏粥样硬化引起的缺血性心脏病：冠心病、心绞痛、心梗、心肌供血不足等。Ischemi
24、c heart disease caused by atherosclerotic heart: coronary heart disease, angina, . .Word 完美格式myocardial infarction, myocardial ischemia.外周动脉粥样硬化引起的缺血性外周血管疾病：下肢动脉硬化闭锁症、血管性间歇性跛行等。Ischemic peripheral vascular disease caused by peripheral atherosclerotic lesions: lower limb arteriosclerosis locked-in sy
25、ndrome and intermittent claudication.肾动脉粥样硬化引起的缺血性肾脏疾病：继发性高血压、肾功能减退。Ischemic renal disease caused by atherosclerotic renal artery stenosis: secondary hypertension, renal hypofunction.肠系膜动脉粥样硬化引起的：肠道功能减退继发的各种疾病。Secondary diseases of intestinal function decline caused by mesenteric arteries2、急、慢性感染性疾病
26、 Acute and chronic infectious disease 对于抗生素或化疗耐药细菌、病毒、真菌。甚至寄生虫感染，如：梨形鞭毛虫病、隐孢子虫病，在古巴医生用臭氧油进行治疗。Antibiotics and chemotherapy drug resistant bacteria, virus and fungus, parasitic infection, such as giardiasis and cryptosporidiosis are treated by Cuban doctors with ozonized oil.3、紧急情况，如在大面积创伤、烧伤、急性腹膜炎、毒
27、血症之后造成的多器官功能衰竭和死亡。联合最好的传统治疗和一天 3 至 4 次的臭氧大自体血疗法可以避免或降低代谢损伤的恶化，降低死亡率。另外，等待器官的病人可以在手术前在 6 至 15 天之间进行 6 至 8 次的臭氧大/小自体血疗法可以提高对于感染的抵抗力和改善免疫抑制（因为麻醉或外科手术） 。同时可以减低器官移植后的缺血再灌流损伤。其他的一般手术也可以将臭氧治疗作为手术前的准备型治疗。Ozone therapy can be applied in emergency circumstances, such as multiple organ failure and death caused
28、 by large area of trauma, burn, acute peritonitis, toxemias. Combining the ozone autohemotherapy for 3-4 times a day with traditional therapy could avoid or reduce the deterioration of metabolism and decrease the death rate. Whats more, patients who are waiting for organs transplant can take 6 to 8
29、times micro or macro ozone authohemotherapy in 6 to 15 days before operation, so as to increase immunity to the infection and improve immunosuppression (caused by . .Word 完美格式anesthesia or surgery). Ischemia and reperfusion injury after the organ transplantation can be reduced. Ozone therapy can als
30、o be used in other general surgery for preoperative treatment.4、骨髓炎、脓胸、腹膜炎、脓疮、褥疮、慢性溃疡、糖尿病足、烧伤、感染性伤口、念珠菌病、甲癣，以上疾病经常伴有抗生素耐药细菌。如耐二甲氧基苯青霉素金色葡萄球菌，抗生素对于感染区域缺乏贯穿，和许多发生在许多发达国家的死亡病例都有联系。在这样病例，臭氧化的自体血回输疗法和局部使用臭氧化橄榄油或葵花籽油起到快速的抗菌作用，并且令人难以置信的加快伤口愈合。臭氧作为一种非常不稳定的气体可以被不饱和脂肪植物油化合为一种稳定的臭氧化物。当臭氧化油被涂在伤口创面的渗出液上，臭氧化油与生物分
31、子反应，生成并释放稳定的过氧化氢。消毒作用和改善的氧化作用可以加速疤痕的形成。一般的传统的药膏经过会含有无用的抗生素和生长因子。臭氧化油一旦被人们知道、使用，必将对数以百万的患者起到极大的治疗作用。The diseases, such as osteomyelitis, empyema, peritonitis, fester, pressure ulcer, chronic ulcer, diabetic foot, burn, infectious wound, candidiasis, onychomycosis, are often accompanied with antibioti
32、cs drug resistance bacteria, such as resistance to dimethoxy benzene penicillium staphylococcus aureus. The antibiotics cannot run through the infected areas, which is connected to the death case happened in many developed countries. In cases like this, ozonized autohemotherapy and partly usage of o
33、zonized olive oil or sunflower seed oil can receive rapid antibacterial effect and promote wound healing. As a very unstable gas, ozone can be chemically combined into a stable ozonide by unsaturated fat vegetable oil. When applied onto the wound surface, ozonized oil reacts with biomolecules and pr
34、oduces and releases stable hydrogen peroxide. The disinfection and improved oxidation effect can accelerate scar formation. Traditional unguent contains useless antibiotics and growth factors. Once the ozonized oil is known and used, it will bring great treatment effects for millions of patients.5、疱
35、疹病毒感染（HHVI 和 II） 、带状疱疹、乳头瘤病毒感染。使用肌肉内注射的小自体血臭氧疗法，作为一种字体疫苗，同时结合臭氧油的局部应用对于. .Word 完美格式预防疱疹的复发非常有作用。这种方法，特别是当联合使用阿昔洛维时，可以治愈绝大部分的疱疹感染病人。同时对于减低带状疱疹感染和感染之后的神经痛也有非常好的效果。 Herpes virus infection (HHV I and II), herpes zoster, infection of papovavirusAs an auto vaccine, combined with partly use of ozonized oil
36、, macro ozone autohemotherapy with muscle injection is very effective in prevention of herpes recurrence. If it is used together with acyclovir, most of the herpes infected patients can be healed. Besides, it can also help reduce varicella-zoster virus infection and effective in lightening neuralgia
37、.6、慢性肝炎和艾滋病感染Chronic hepatitis and AIDS infection7、自身免疫性疾病（痛风、多发性硬化、类风湿性关节炎、克隆病） 。自体血疗法是非常令人鼓舞的。Autoimmune disease (gout, multiple sclerosis, rheumatoid arthritis, Crohns disease)Autohemotherapy is very inspiring. 8、退行性疾病。自体血疗法可以改善老年性痴呆早期的患者。Degenerative diseaseAutohemotherapy could help improve ear
38、ly stage Alzheimer disease.9、肺部疾病（肺气肿、哮喘、COPD、急性呼吸窘迫综合征） 。Pulmonary disease (pulmonary emphysema, asthma, COPD, acute respiratory distress syndrome) 10、对于 COPD 的治疗原理如下： A、血液回输，脂质氧化物可以作用内皮细胞表面，提高前列腺环素和 NO 的释放，而内皮缩血管肽 I 的释放被抑制。NO和亚硝基硫醇的释放促进血管舒张，而阴离子超氧化物的释放会造成血管紧缩，并且对血小板和内皮细胞产生负面影响；B、缺血组织氧输送的增强、抗氧化酶的加强
39、、血红素加氧酶 I 中和慢性氧化应激。C、对于免疫系统刺激可以控制慢性肺部感染。通过臭氧治疗 COPD 可以达到良好的效果，包括改善呼吸系数和步行试验。The treatment principle of CODP: A. Through the treatment, lipid peroxide acts on the surface of endotheliocyte and . .Word 完美格式increase the releasing of prostacyclin and NO, thus the releasing of endothelin-1 is restrained.
40、 The producing of NO and S-nitrosothiols will promote vasodilatation while the releasing of anionic superoxide will lead to vasoconstriction and have a negative impact on platelets and endothelial cells.B. Ischemic tissues oxygen transportation and antioxidant enzyme ability will be strengthened; ha
41、em oxygenase I neutralize chronic oxidative stress.C. Stimulation on immune system helps control chronic pulmonary infection. Ozone treatment for CODP will achieve good results, including improve respiration coefficient and minute walking test.11、期肾病被慢性氧化应激加重，不能被传统药物控制，臭氧治疗稳定严重的功能障碍，提高病人的生活治疗。Renal
42、disease in late stage cannot be controlled by traditional medicine because of chronic oxidative stress. The ozone therapy stabilizes the dysfunction and improves patients life quality.12、臭氧自体血回输疗法联合臭氧油的局部应用被证明对于代谢综合征非常有效，比如 2 型糖尿病患者的难治性慢性溃疡。Ozone autohemotherapy, combined with ozonized oil partly ap
43、plied, is proved to be effective in metabolic syndrome treatment, such as refractory chronic ulcer of type 2 diabetes patient. 13、皮肤病（牛皮癣、异位性皮炎） 。Dermatopathya (psoriasis, atopic dermatitis)14、化疗药耐药的转移癌、癌性疲劳。通过臭氧治疗可以提高病人的生活质量，但是不可以阻断癌症的发展。另一方面，外科手术之后臭氧治疗非常有效，不仅可以通过诱导抗氧化反应强化细胞毒药物的作用，而且可以降低化疗药的毒性。Meta
44、static cancer resisting to chemotherapeutic drugs and cancer fatigue.Although the cancerous development cannot be stopped, the ozone therapy will improve patients life quality. On the other side, ozone therapy is very effective in postoperative treatment. This therapy can not only strengthen cytotox
45、ic drugs effect by inducing the antioxidant response, but also decrease chemotherapeutic drugs . .Word 完美格式toxicity.15、慢性疲劳综合征和纤纬肌痛。自体血疗法已经被发现对于大多数的病人有效。Chronic fatigue syndrome and firbre muscle pain It is found that the macro ozone autohemotherapy is effective among most of patients（二）臭氧大自血疗法禁忌症 C
46、ontraindications of Macro Ozone Autohemotherapy甲亢、葡萄糖-6 磷酸脱氢酶（G-6PD）缺乏症、心肌梗塞发作、孕妇、血小板减少、凝血机制障碍、臭氧过敏、急性乙醇中毒、柑橘过敏等。四、医用臭氧大自血疗法发展史 Development History of Medical Ozone Autohemotherapy1.1857 年德国的 Werner von Siemens 制造出第一种臭氧发生器。Werner von Siemens from Germany manufactures the first ozone generator in 185
47、3.2.1870 年德国 C. Lender 报道了第一例医用臭氧治疗性的进行血液疗法。C. Lender reported the first case that adopts medical ozone to carry out hematotherapy in Germany in 1870.3.1902 年，J.H.Clarkes A Dictionary of Practical Materia Medica （实用药物学辞典）的书中描述了很多成功应用臭氧水治疗贫血，癌症、糖尿病、流感、吗啡中毒、口疮、马钱子碱中毒、百日咳。J.H.Clarkes A Dictionary of Pr
48、actical Materia Medica describes many successful cases that apply ozonized water into treatment of anemia, cancer, diabetes mellitus, influenza, morphinism, aphtha, strychninism, and pertussis.4.在 1911 年，Dr. Noble Eberhart 出版了“A Working Manual ofHigh Frequency Currents“,他是 Loyola 大学生理治疗部门的主任，他同样应用臭氧
49、治疗了结核病、贫血、萎黄病、百日咳、哮喘、支气管炎、花粉热、失眠、肺炎、糖尿病、痛风、梅毒。Dr. Noble Eberhart published A Working Manual ofHigh Frequency Currents in 1911. As the director of therapy department, Dr. Eberhart treats many diseases with ozone, . .Word 完美格式such as tuberculosis, anemia, chloranemia, pertussis, asthma, bronchitis, pollenosis, insomnia, pneumonia, diabetes mellitus, gout, syphilis.5.1929 年，一本叫臭氧和它的治疗作用在美国被出版，书中列出 114 种疾病以及如何应用臭氧去进行治疗，书的作者们是美国一些顶尖医院的学术权威
