1、Fenvalerate,氰戊菊酯,What is fenvalerate？,Fenvalerate is an insecticide., type Pyrethroid (型拟除虫菊酯类农药),Fenvalerate is one of an environmental endocrine disruptor,EEDs,Hormone and Hormone receptor,disrupt,Fenvalerate was firstly produced by Sumitomo Chemical company(日本住友商事) at 1976 in Japan,Molecular form
2、ula: C25H22ClNO3Appearance: Yellow-brown viscous liquidMolecular weight: 419.91,C25H22ClNO3,It is a mixture of four optical isomers(光学异构体)which have different insecticidal activities. The 2-S alpha (or SS) configuration is the most insecticidally active isomer.Fenvalerate consists of about 23% of th
3、is isomer,It is found in some emulsifiable concentrates (乳剂), wettable powders(粉剂), slow release formulations, insecticidal fogs(雾化剂), and granules(颗粒剂).,It is most commonly used to control insects in food, feed, and cotton products, and for the control of flies(苍蝇) and ticks(蜱) in barns and stables
4、.,0.0031mg/kg,Impairment,Fenvalerate is most toxic to bees and fish, especially to aquatic organisms(水生生物),Fenvalerate is an insecticide of moderate mammalian(哺乳动物的) toxicity Fenvalerate may irritate the skin and eyes on contact,Link to information on toxicity to humans, including carcinogenicity(致癌
5、), reproductive and developmental toxicity, neurotoxicity, and acute toxicity(急性中毒).,Under some experimental conditions, fenvalerate may impair reproductive development of female offspring, manifested as reduced fecundity and ovulation number, resulting from the impairment in corpora lutea counting(
6、Guerra MT, de Toledo FC. Kempinas WD.In utero and lactational exposure to fenvalerate disrupts reproductive function in female rats. Reprod Toxicol. 2011.25. ),In laboratory animals, central nervous system toxicity is observed following acute or short-term exposure Some studies suggest that pubertal
7、 fenvalerate exposure disrupts testosterone (T) and estradiol synthesis and the expression of AR in cerebral cortex. These changes of steroid status in the developing brain might be deleterious for neurobehavioral development,Also some results suggest that pubertal fenvalerate exposure impairs spati
8、al cognition and behavioral development in a gender-dependent manner. These findings identify fenvalerate as candidate environmental risk factors for cognitive and behavioral development, especially in the critical period of development.,So, we should know what fenvalerate is, study it, and propound intervention. Less exposure, little contact, reduce fenvalerate impairing our body, protect our health.,Thanks for you attention!,
