1、$DT 2 + u 29Db + /#h ( 2,210002)2vD “5 V 3( F)h0yF王瑞石 8 胡伟新 0 ,n1oM 0 0yF 3h、 7A 75%h# / ? By , ?,460 TrplM q AF, ONM1SEWs;z BlMy ) M ,O / 。 P_ X 2,zlMadduciny? ( / A,4 UBlM /#Na+ ?AY。i N (-adducinyB ?C MMs,NMs ?h1 i AMcT。Gilorioso164 y (Gly 460 Trp)1“,T (Milan)4yMsM1,7(Sassari), ?CAM1。 1 ?C,v 460 T
2、rpy q53%57%, 56%66%, 1“4 17 ; 6B 5 “ Gly460 TrplMW1“18 。 ,460 Trpy q27%, % )9 1“19 。K,SqB?g_-adducinyGly460 Trp ,M1s?CMs?h C1 ,9M120 。2.2 药物基因组学研究在高血压治疗中的应用前景2.2.1 RAAS“d F4 r(1)AGTy rY Hin-gorani21 5 、G * 、 v # ) 5f 4(ACEI)rT H?C:T/T、T/My /1M/MyA, ?ACEI 0QssL.y %。 7,Dudley22?C,M235T 8v Qs1。9,AGTy A
3、CEIrT1“B。(2)ACEy rY 1ACEy ACEI r,T9B。Stavroulakis23 (fosinopril) rACEy1“ H,?CDDy l # f ( II、IDA/, O r M -、8 1。7Otoole24?C,IIy1ID、DDy 。Dudley22T4 U, v rACEy AM1。Mondorf255 L 5 rACEy 1。K,Ueda26 G * T,TV IIy 3r , ,.- = lGly460 TrpMsSqB ?M1.DL.,2000,17:41721 Hingorani AD, Jia H, Stevens PA, et al.Renin-
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