1、 : 1001 -764X (2009)02 -0155-03 :R 446 .1 : A # # * 张 茜 1 综 述, 郭 健 2 审 校( 1 . / , 100730 ; 2. , 100730) : 髓 过 氧 化 物 酶; 动 脉 粥 样 硬 化; 急 性 冠 状 动 脉 综 合 征; 心 力 衰 竭 (m y e lo p e r o x id a s e ,M P O ) , , , (A s ) M P O 1 M P O M P O 150000 , 2 (466 ) 2 (108 ) , M P O ( P M N ) , , ,M P O 1 P M N M P O
2、M P O M P O H 2 O 2 ,M P O M P O-Fe ( ) H 2 O 2 ,M P O M P O-Fe ( )= O + P , : 2 , M P O-Fe ( ) 2 , ( ) , M P O-Fe ( )= O M P O-Fe ( ) 2 ( 1) 1 M P O M P O , M P O (HOC l ) HOC l , HOC l , A s M P O (NO ) , ( NO - 2 ) M P O H 2 O 2 ,NO - 2 ( NO . 2 ) NO . 2 , , 3 , 2 M P O 2 .1 , 3,3c - , M P O Br a
3、 d le y 4 M P O : p H 6 .0 , H 2 O 2 3,3c - ,M P O , 460 n m , M P O 1 U M P O 25 e 1m in 1L m o l H 2 O 2 M P O , ( ) ( ) 2 .2 (ELI S A ) M P O , , n g / m l ; , , , , , , Ch a n g 5 ELI S A M P O , M P O ( 14.8 77.1 n g / m l ) , M P O 2 .3 M P O , , ( ) M P O , M P O , , M P O , , 3 M P O 3 .1 (
4、A CS ) Br e n n a n 6 604 M P O , 16 h (M I) M P O M I (P 0 .001) ,M I M P O (P 0 .001) , M P O 30 d 6 ( ) Ba ld u s 7 1 090 A CS 6 155 2009 27 2 Ch i n e s e Jo u r n a l o f C l in i c a l La b o r a t o r y S c i e n c e ,2009,V o l1 27,N o1 2 * : ( 2006A A 020901 D) : ,1983 , , : , , : g u o j i
5、a n c l in e t.c o m .c n M I , M P O ( 350L g /L) ( HR = 2.25, 95% CI1 .32 3.82, P = 0 .003 ) M o c a t t a 8 512 M I 5 , M P O 5 ( OR = 1 .8,95% C I1 .0 3.0 ,P = 0 .034) M P O A CS , , M P O T ( c T n T ) 0 .01L g / L A CS ( HR = 7. 48, 95% CI1 .98 28.29 ,P = 0 .001) M P O , , M P O , , , , ,M P O
6、 C ( CR P ) A CS , , 3 .2 (CA D) M e u w e s e 9 3 375 M P O , 8 CA D M P O CA D (P 0 .001) ; ,M P O CA D ( OR = 1 .36,95% C I1 .07 1 .73,P 0 .001) M P O , CA D ,M P O , CA D M e u w e s e 1 0 ,M P O 3 .3 T a n g 11 102 , M P O ( 1 158 ? 2 965) ( 204 ? 139)p m o l /L,P 0 .001 ( NY HA ) ,M P O NY HA
7、(P 0 .001) , M P O T a n g 12 140 M P O , 4 ( ) M P O , ; B ( BNP ) , M P O ( R R = 3.35,95% CI1 .52 8.86,P = 0 .002) ,N g 13 M P O ( LV S D) 1 360 LV S D , LV S D B N ( NT -p r o BN P ) CR P M P O (P 0 .005) NT -p r o B - N P CR P M P O R OC , 0 .839 0 .824 0 .909 , M P O , M P O NT -p r o BNP , ,
8、NT -p r o BNP CR P M P O , 94.3% 4 M P O M P O A s , , , , 4 .1 NO , GT P c GM P , ,M P O , , , , NO, NO , 1 4 A s 4 .2 A s M P O , 4 .2 .1 LDL ( o x -LDL) M P O ( ) LDL, o x -LDL , CD3 6 o x -LDL, , A s 4 .2 .2 A - ( a p o A - ) HDL , , a p o A -I HDL Z h e n g 15 M P O a p o A -I , A T P A 1 M P O
9、 a p o A -I , 8 16 4 .3 A s (M M P s ) , M P O HOC l M M P s , M M P s , M M P s , , A s , A CS Fu 17 M P O HOC l M M P -7 , , , M M P -7 4 .4 V a s i l y e v 18 M I , 24 d , M P O , M P O M I 5 M P O , A CS , M P O M I , M P O A CS , M P O c T n T , c T n T , M P O , ,M P O , , , M P O , : 1 W in t
10、 e r b o u r n C C,V i s s e r s M C,Ke t t l e A J .M y e lo p e r o x id a s e J .Cu r r O p in H e m a to , l 20 00 ,7( 1) : 53-58 . 2 De b y - Du p o n t G,De b y C, La m y M .N e u t r o p h i l m y e lo p e r o x id a s e r e v is - i t e d : It. s r o l e in h e a l t h a n d d i s e a s e J
11、. I n t e n s iv m e d i z in u n d N o t f a l- l m e d i z in ,1999 , 36( 6) : 50 0 -513. 3 E i s e r i c h JP ,Ba ld u s S ,Br e n n a n M L , e t a l. M y e lo p e r o x id a s e, a l e u k o- c y t e-d e r iv e d v a s c u la r N O o x id a s e J .S c ie n c e, 2002 , 296 ( 5577) : 156 2009 27
12、2 Ch in e s e Jo u r n a l o f C l in ic a l La b o r a t o r y S c ie n c e, 2009 ,V o l1 27 ,N o1 2 2391 -2394 . 4 Br a d le y P P , P r ie b a t DA ,Ch r is t e n s e n R D,e t a l. M e a s u r e m e n t o f c u - t a n e o u s in f la m m a t io n : e s t im a t i o n o f n e u t r o p h i l c o
13、 n t e n t w i t h a n e n z y m e m a r k e r J .J I n v e s t De rm a to , l 1982,78: 206 -209 . 5 Ch a n g P Y ,W u T L ,Hu n g C C, e t a l. De v e lo p m e n t o f a n ELI S A f o r m y e lo p e r o x id a s e o n m ic r o p l a t e : N o rm a l r e f e r e n c e v a lu e s a n d e f fe c t o f
14、 t e m p e r a t u r e o n s p e c im e n p r e p a r a t io n J .C l in Ch im A c t a, 2006 , 373 ( 1 -2) : 158 -163. 6 Br e n n a n M L , P e n n M S ,V a n Le n t e F , e t a l. P r o g n o s t ic v a lu e o f m y- e lo p e r o x id a s e in p a t ie n ts w it h c h e s t p a in J .N E n g l JM e
15、 d , 2003, 349 : 1595-160 4. 7 Ba ld u s S ,H e e s c h e n C,M e in e r t z T ,e t a l. M y e lo p e r o x id a s e s e r u m l e v e ls p r e d i c t r i s k in p a t ie n t s w i th a c u t e c o r o n a r y s y n d r o m e s J .C ir c u l a- t i o n , 20 03,108 : 1440 -1445. 8 M o c a t t a T J
16、,P i lb r o w A P ,C a m e r o n V A ,e t a l. P l a s m a c o n c e n t r a t io n s o f m y e lo p e r o x id a s e p r e d i c t m o r t a l i ty a f t e r m y o c a r d ia l in f a r c t i o n J .J A m C o l l C a r d io , l 2007 , 49( 20) : 1993-200 0 . 9 M e u w e s e M C, S t r o e s E S G,H
17、a z e n S L , e t a l. S e r u m m y e lo p e r o x id a s e l e v e ls a r e a s s o c ia t e d w i th th e fu tu r e r is k o f c o r o n a r y a r t e r y d is e a s e in a p p a r e n t ly h e a lt h y in d iv id u a l s th e EP I C- N o r f o lk p r o s p e c t iv e p o p u l a- t i o n s t u d
18、 y J .JA CC,2007 , 50( 2) : 159-165. 10 S t e fa n e s c u A ,Br a u n S ,N d r e p e p a G, e t a l. P r o g n o s t ic v a l u e o f p l a s m a m y e lo p e r o x id a s e c o n c e n t r a t io n in p a t i e n t s w i th s t a b le c o r o n a r y a r t e r y d i s e a s e J .A m H e a r t J ,2
19、008 , 155( 2) : 356 -360 . 1 1 T a n g W , Br e n n a n M ,P h i l ip K .P l a sm a m y e lo p e r o x id a s e le v e l s in p a- t i e n t s w i t h c h r o n i c s y s to l ic h e a r t fa i lu r e J .A m JC a r d i o , l 2006 , 98 : 796 -799. 1 2 T a n g W ,T o n g W ,T r o u g h to n R W , e t a l. P r o g n o s t ic v a lu e a n d e c h o- c a r d i o g r a p h i c d e t e rm in a n t s o f p la sm a m y e lo p e r o x id a s e l e v e ls in c h r o n - i c h e a r t f a i lu r e J . JA m Co l l C a r d io
