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8、(Suppl 1): 144153.11 Dunbar L M. Current issues in the management of bacterial re-spiratory tract disease: the challenge of antibacterial resistanceJ. Am J Med Sci, 2003, 326(6):360 368.12 Leclercq R. Safeguarding future antimicrobial options: strategiesto minimize resistance J. Clin M icrobiol Infe
9、ct, 2001, 7: 1823.13 Martinezo-Freijo P, Fluit A C, et al. Class integrons in gram-negativeisolates from different European hospital and associationwith decreased susceptibility to multiple antibiotic compoundsJ. J Antimicrob Chemother, 1998,42(6): 689 696.14 McKeegan K S, Borges-Walmsley M I, Walms
10、ley A R. Thestructure and function of drug pumps: an updateJ. TrendsMicrobiol, 2003, 11(1): 21 29.15 Niederman M S. Appropriate use of antimicrobial agents: chal-lenges and strategies for improvementJ. Crit Care Med, 2003,31(2): 608 616.16 Poly M C, Denis F, Courvalin P, et al. M olecular characteri
11、zationof integrons in A cinetobacter baumannii: description of a hybridclass 2 integron J. Antimicrobial Agents and Chemotherapy,2000, 44(10): 2684 2688.17 Ross S, Rodroguez W, Controni G, et al. Staphylococcal suscep-tibility to penicillin G: The changing pattern among communityisolatesJ. JAMA, 197
12、4, 229(8): 1075 1077.TheCauses, MechanismandPreventiveMeasuresof BacterialResistanceZHAO Ming-qiu, SHEN Ha-i yan, PAN Wen, WANG Jia-ying, LI Yin-guang, CHANG Yan(College of Veterinary Medicine, South China Agricultural U niversity, Guangzhou 510642, China)Abstract: With the advent of penicillin in t
13、he 1940s an era of antibiotics was started, ant-i infection treatment thus entereda new era, the mortality rate of infectious diseases decreased dramatically. For a half century, humans have always consideredantibacterial drugs as the most powerful weapon of ant-i infection treatment. However, with
14、thewideapplication of antimicrob-ial agents, the treatment of infectious diseases also meet the new challenges-bacterial resistance to antibiotics, which becomemore serious as the usage of antimicrobial is increased. Currently some bacteria have been found susceptible to almost all theantimicrobial
15、agents, theappearance of super bacteriamay bring humans back to the dilemma of no medicine for infectious dis-eases, so the control of the increase of bacterial resistancehas becomeurgent for medicine and humankind. Our country is grad-ually building our own monitoring network of bacterial resistance, monitoring of the current epidemic status and trends of bac-teria resistant, studying on the mechanism of bacteria resistant.Keywords: bacteria; drug resistance; prevention 5 _ m6 35,5 s_6 34, , h :100193 S j S $ uD 5S $ uD6I lb#181#S $ uD 2011 M38 5 %h
