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类型肺癌肿瘤倍增时间特点及其病理学基础.pdf

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    肺癌肿瘤倍增时间特点及其病理学基础.pdf
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    1、26 6 2009 M 12 3DJournal of Biomedical Engineering Vol.26 No.6December 2009k ?9 HW+# h $李 媛 综述 杨志刚 审校(四川大学华西医院放射科,成都 610041)K1 B ZEklS 4。 ?9 HW Q ? 3+1,9 kl ?9 HW, 1N。 M ,sO qCT(High resolutionCT, HRCT) C T(M ulti-detector row CT, M DCT) ?9 HW | BtZ,“k ?9 HW+# h $TB8 。1oM k ?9 HW sO qCT CT h ms | R3

    2、18.5;R814.4 DS M A cI| 1001-5515(2009)06-1388-03CharacteristicsandPathological BasisofTumor DoublingTime inLungCancerLiYuan YangZhigang(Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China)Abstract It is difficult to make a definite diagnosis of lung cancer only ba

    3、sed on the morphological features.Asthe tumor doubling time is a good index of tumor grow th, the diagnosis of lung cancer can be substantiated by meas-uring the tumor doubling time.Recently, the researches using high resolutioin CT (H RC T)or multi-detector rowCT (M DCT)to calculate the tumor doubl

    4、ing time of lung cancer and the clinical applications have made some pro-gress.In this paper, we review ed the pathological basis and characteristics of tumor doubling time in lung cancer.Keywords Pulmonary nodule Tumor doubling time High resolution CT (HRCT) M ulti-detectorrow C T(M DCT) Pathology1

    5、 “5C T_CT k?Ckl,h ?、 o,D = BG。 ( vl、 =、Hh1)ZE ?T, kl PsO qCT(H igh resolution CT,H RC T)g 4。N H,YVC T6,1 8M,9 ?9 HW,kl1N。 M ,H RC TLECT(M ulti-detector row C T,M DCT)8E N ?9 HW “5 | BtZ,C8 。2 k ?9 HWZE 1 “5NZE。YV1 QYT。E-mail:yan gzg1117y _ H8M 9 ? 3 。9HW 89FB HW。V XL CTkL,| 89 TV=/6ab2,9 HWVDT=tlog2

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    10、C 3, k J。 HGGO,17%,vl(15.23.6)mm ,CT(-440130)H u, u-150 H u,Hu-610 Hu。h VC ?8893,k J,H u ?%C T 3,k J。 ( F ,27%,vl(14.52.7)mm,CT(1030)H u,h VC ? L8 3,c k F。YangH RC Ts N oguchiklFh zB, 94%A ?VC,71%B ?VC,29%C ?VC,50%C ?VC,100%D、E#F ?VC。kCTVC+B V U “5。Yang12 N F ?9 HWf ,?CA、B ?cGGOs, ?9 HWv1 M, ? 3;7D、

    11、EF L8s, ?9 HW lB M, ? 3。Kim14 227 5k #F,GGOz,z, TA UGGO1 %M、)M ?M1(PsY0.017、0.0070.020)。Aoki 1517 lFGGO1 50%, %M ?。9,lFH RCT GGOs1 ,h ?%k C 3s(1nA、B), ?9 HW, %M q, “5 z。Q,cGGO1 ,h 1 L8 3(nD、EF), ?9 HW , %M q, “5M 16,17 。13893D 26 5 ?9 HWkNCT k “5CT_?Ckl,h ?、 o, D = BG18,19 。B ,CT ?Cl, n5 H RCT , m)

    12、, y。vl、 、H、 =(GGO、 b 5 )、CT#HkFf 8s, VT,HlkQH RCTB 4,64。6 #4W HW4。5 1,BZ 1h h 6#XL 4 , 6BZ 1*lk,#H m M“,4h 5 M 3i q。 ?9 HW %6 HW SZE,BGGOR4 6C T,7GGOi L8zR2 3CT,B L8R1 2CT。N, 9Y ?9 HW,yN kR1 2CT,7 R3 4CT。CT6,O9vvlM 9,Pk,yp m M“。9, “/ ?,k ?9 HWF% ,M V k ?9 HWs M。* klFH RC T BGGOzGGO, ?9 HW ,v400 d, “

    13、5 z。 M ?9 HW+,|klC T6、kY。 ID 1 H AS EGAWA M, SONE S, TAKAS HIMA S, et al.Grow thrate of small lung cancers detected on m ass C T screening J.Br J Radiol, 2000,73(876):1252-1259. 2 KOS TIS W J, YANKE LEVI TZ D F, REE VES A P, et al.Small pulmonary n odu les:Reproducibility of three-dim ension-al volu

    14、m etric measu rement an d estimation of time to follow-upCT J.Radiology, 2004, 231:446-452. 3 YANKELEVITZ D F, REEVES A P, KOS TIS W J, et al.Small pulm onary n odu les:Volumetrically determined grow thrates b ased on C T evaluation J.Radiology, 2000, 217:251-256. 4 JENNINGS S G, W IN ER-MU RAM H T

    15、, ROBE RT D, etal.Lung tu mor grow th:Assessment with CT comparison ofdiam eter an d cross-sectional area w ith volu me m easurements J.Radiology, 2004, 231:866-871. 5 GOO J M , TONGDEE T, TONGDE E R, et al.Volumetricmeasu rement of synthetic lu ng nodules w ith multi-detectorrow C T:Effect of vario

    16、u s image recon struction parametersand segmentation th resh olds on measurem ent accu racy J.Radiology, 2005,235:850-856. 6 REVE L M P, ME RLIN A, PEYRA RD S, et al.Softwarevolumetric evaluation of doubling times for differentiating be-nign versu s malignant pulmonary nodules J.Am J Roent-genol, 20

    17、06, 187(1):135-142. 7 JENNINGS S G, WINE R-MURAM H T, ROBE RT D, etal.Distrib ution of stage I lung can cer g row th rates determinedwith serial volumetric CT measu rements J.Radiology,2006, 241(2):554-563. 8 LINDEL L R M, H ART MAN T E, S WENS EN S J, et al.Five-year lung cancer screening experienc

    18、e:CT appearance,grow th rate, location, and histologic featu res of 61 lung canc-ers J.Radiology, 2007, 242(2):555-562. 9 YANG Z G, SONE S, LI F, et al.Visibility of small periph-eral lung cancers on chest radiographys:influence of den sito-m etric param eters, C T valu es and tum or type J.Br J Rad

    19、i-ol, 2001, 74(877):32-41. 10 SONE S, NAKA YAMA T, H ONDA T, et al.C T finding sof early-stage small cell lung cancer in a low-dose C T screen-ing p rog ramme J.Lung Can cer, 2007, 56(2):207-215. 11 NOGUC HI M, MORIKAW A A, KAWASAKI M , et al.Small adenocarcinoma of the lung:histological characteris

    20、ticsand prognosis J.C ancer, 1995, 75(12):2844-2852. 12 YANG Z G, SONE S, TAKAS HIMA S, et al.High-resolu-tion CT analysis of sm all peripheral lung adenocarcinomas re-vealed on screening helical C T J.AJR, 2001, 176(6):1399-1407. 13 YANG Z G, SONE S, T AKAS HIM A S, et al.Small periph-eral carcinom

    21、as of the lun g:Thin-section CT and pathologiccorrelation J.Eu r Radiol, 1999, 9(9):1819-1825. 14 KIM E A, JOH KOH T, LEE K S, et al.Quantification ofground-glass opacity on high-resolution CT of small peripheraladenocarcinoma of the lu ng:pathologic and prog nostic impli-cations J.AJR, 2001, 177:14

    22、17-1422. 15 AOKI T, NAKA TA H, W AT ANABE H, et al.Evolutionof perip heral lu ng adenocarcin om as:C T findings correlatedwith histology and tumor doub ling time J.AJR, 2000, 174(3):763-768. 16 ASAMU RA H, S UZUKI K, WAT ANABE S, et al.A clini-copathological study of resected subcen timeter lung can

    23、 cers:afavorab le prognosis for g rou nd glass opacity lesions J.An nTh orac Su rg, 2003, 76(4):1016-1022. 17 OHT A Y, SH IMIZU Y, KOBAYASH I T, et al.Pathologicand biological assessment of lun g tumors show ing ground-glass opacity J.An n T horac Surg, 2006, 81(4):1194-1197. 18 JET T J R, MIDTH UN D E.Screening for lung cancer:cu r-rent status and future direction s:T homas A.Neff lecture J.C hest, 2004, 125(5 Su ppl):158S-162S. 19 HE NS CHK E C I, YANKELEVITZ D F.C T screening forlung cancer:Update 2007 J.Oncologist, 2008, 13(1):65-78.( l:2008-09-01 :2008-12-05)1390

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