1、L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessmentsmm Zeynep Avsar 1, Umit Avsar 2, Ali Aydin 3, Muhammed Yayla 4, Berna Ozturkkaragoz 5, Harun Un 6, Murat Saritemur 7, Tolga Mercantepe 81 Department of Medical Education, Faculty of Medicine, Ata
2、turk University, Yakutiye, Erzurum, Turkey2 Department of Family Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey3 Department of Orthopedics and Traumatology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey4 Department of Pharmacology, Faculty of Medici
3、ne, Ataturk University, Yakutiye, Erzurum, Turkey5 Department of Pharmacology, Faculty of Pharmacy, Agr? University, Agr?, Turkey6 Department of Biochemistry, Faculty of Pharmacy, Agr? University, Agr?, Turkey7 Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzu
4、rum, Turkey8 Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey摘要 已有研究显示，乙酰左旋肉碱对糖尿病大鼠损伤坐骨神经有保护作用。实验假设左旋肉碱对损伤坐骨神经有保护作用。实验结果显示，钳夹大鼠坐骨神经造成压榨伤的坐骨神经出现退行性变。给损伤坐骨神经大鼠左旋肉碱灌胃 50 mg/kg 和 100 mg/kg 30d 后，损伤的坐骨神经轴突和髓鞘面积、轴突直径和髓鞘直径、有髓鞘轴突密度接近正常；坐骨神经功能也明显改善，说明
5、左旋肉碱对坐骨神经压榨伤有保护作用。关键词： 神经再生； 周围神经损伤； 坐骨神经； 左旋肉碱； 神经保护； 压榨伤； 电镜； 轴突； 髓鞘； Fund: 土耳其 Ataturk 大学科学研究项目Acceptance date: 2014-03-20 Cite this article:mm Zeynep Avsar, Umit Avsar, Ali Aydin, Muhammed Yayla, Berna Ozturkkaragoz, Harun Un, Murat Saritemur, Tolga Mercantepe. L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessmentsJ. Neural Regeneration Research, 2014, 9(10): 1020-1024.
