1、SICENCE 新闻发布 作者：刘学政 稿号：N201306013Nogo 受体表达抑制可明显减少糖尿病视网膜神经节细胞凋亡Nogo 受体的激活是抑制神经再生，导致神经元萎缩甚至凋亡的重要因素。Nogo 受体表达上调是青光眼等疾病神经节细胞凋亡、视力减退的重要原因，但糖尿病状态下神经节细胞凋亡是否与Nogo 受体基因表达变化相关？目前尚不清楚。中国辽宁医学院刘学政博士所领导的团队的一项研究以 RNA 干扰手段抑制糖尿病大鼠视网膜 Nogo 受体的表达，结果显著抑制 Rho 激酶表达，同时糖尿病大鼠视网膜神经节细胞凋亡也明显减少。说明 Nogo 受体表达上调是糖尿病大鼠视网膜神经节细胞凋亡的重要
2、机制之一，可能与 Nogo 受体下游分子 Rho 激酶表达变化有关。相关结果发表在中国神经再生研究（英文版） 杂志 2014 年 4 月第 8 期。荧光免疫组化染色显示抑制Nogo受体表达的糖尿病大鼠视网膜神经节细胞内ROCK阳性表达减少Article: “ Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats,“ by Xuezheng Liu1, Zhongfu Zuo1, Wanpeng Liu1, Zhiyun Wang1, Yang H
3、ou2, Yunjie Fu1, Yuzhi Han1 (1 Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China; 2 Scientifc Experimental Center, Liaoning Medical University, Jinzhou, Liaoning Province, China)Liu XZ, Zuo ZF, Liu WP, Wang ZY, Hou Y, Fu YJ, Han YZ. Upregulation of Nogo receptor e
4、xpression induces apoptosis of retinal ganglion cells in diabetic rats. Neural Regen Res. 2014;9(8):815-820.欲获更多资讯：Neural Regen Res SICENCE 新闻发布 作者：刘学政 稿号：N201306013Inhibition of NgR expression reduces apoptotic retinal ganglion cells in diabetes Activation of Nogo receptor (NgR) is an essential fac
5、tor of nerve regeneration inhibition, neuronal atrophy and even apoptosis. Upregulation of NgR expression is an important cause of cell apoptosis and visual extinction in some diseases including glaucoma. Whether ganglion cell apoptosis is related to NgR gene expression in diabetes mellitus remains
6、poorly understood. Dr. Xuezheng Liu and his team, Liaoning Medical University, China interfered NgR expression in the retinal ganglion cells of rats with diabetes mellitus and found that Rho kinase expression was obviously inhibited and retinal ganglion cell apoptosis was evidently reduced in rats w
7、ith diabetes mellitus. These results indicate that upregulation of NgR expression is an important mechanism of retinal ganglion cell apoptosis in rats with diabetes mellitus, which is likely to be related to changes in Rho kinase expression in NgR downstream molecules. Related results were published
8、 in Neural Regeneration Research (Vol. 9, No. 8, 2014).Immunohistochemical staining revealed that after inhibition of Nogo receptor expression in retinal ganglion cells of rats with diabetes mellitus, Rho-associated protein kinase-positive cells were reduced. Article: “ Upregulation of Nogo receptor
9、 expression induces apoptosis of retinal ganglion cells in diabetic rats,“ by Xuezheng Liu1, Zhongfu Zuo1, Wanpeng Liu1, Zhiyun Wang1, Yang Hou2, Yunjie Fu1, Yuzhi Han1 (1 Department of Anatomy, Liaoning Medical University, Jinzhou, Liaoning Province, China; 2 Scientifc Experimental Center, Liaoning Medical University, Jinzhou, Liaoning Province, China)Liu XZ, Zuo ZF, Liu WP, Wang ZY, Hou Y, Fu YJ, Han YZ. Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats. Neural Regen Res. 2014;9(8):815-820.
