1、Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stressJianbo Zhao 1, Zhengkai Zhao 3, Shiqiang Fang 1, Yajiang Yuan 1, Zhanpeng Guo 1, Jinhao Zeng 1, Yue Guo 1, Peifu Tang 2, Xifan Mei 11 Vertebral Column Ward, Department of Orthopedics, First Affiliated
2、 Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China2 Department of Orthopedics, General Hospital of Peoples Liberation Army, Beijing, China3 Department of neurology, Jinqiu Hospital, Shenyang, Liaoning Province, China摘要 绿茶多酚是人体内自由基的清除剂，具有较强的抗氧化作用，能降低氧化应激水平。绿茶多酚的对抗氧化应激作用是否能减轻脊
3、髓神经元损伤呢？实验应用双氧水刺激大鼠脊髓神经元构建氧化损伤模型，用不同浓度（50-200 ?g/mL）绿茶多酚作用 24 h 后检测细胞内丙二醛含量和超氧化物歧化酶水平，以及与凋亡相关的基因和蛋白表达水平。结果显示，绿茶多酚能有效降低脊髓损伤后大鼠脊髓神经元内的氧化应激水平，抑制细胞凋亡。说明绿茶多酚干预对氧化应激损伤后的脊髓神经元具有保护效应。Acceptance date: 2014-05-23 Cite this article:Jianbo Zhao, Zhengkai Zhao, Shiqiang Fang, Yajiang Yuan, Zhanpeng Guo, Jinhao Zeng, Yue Guo, Peifu Tang, Xifan Mei. Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stressJ. Neural Regeneration Research, 2014, 9(14): 1379-1385.
