1、SICENCE 新闻发布 作者：周胜虎 稿号：NRR_229_14绿茶多酚溶液保存的同种异体神经移植修复周围神经缺损 来自中国兰州军区总医院的周胜虎所在团队的最新研究发现，1 mg/mL 的绿茶多酚溶液在 4环境下保存的同种异体坐骨神经移植修复 1.0 cm 坐骨神经缺损可以在神经形态和功能两方面显示出，且恢复效果均优于辐照处理的异体神经移植。在用同种异体神经移植时，首先需处理免疫排斥问题，目前用于解决这一问题的方法有低温冷冻、冻干、冻融、血浆浸泡和辐照等方法。放射辐照降低异体神经的排斥反应。其作用机制可能是X 射线杀死许旺细胞，破坏其继续分泌抗原物质的功能，并通过保留的神经膜管结构支架使周围
2、神经得以再生。但经上述方法处理的异体神经不具有抗菌性能，不能有效防治移植后的感染；而术后感染往往是异体神经移植后失败的一个重要原因。近年研究发现，绿茶具有抗炎及神经保护等多种药理作用，其主要成分是绿茶多酚。Ikeguchi 等采用绿茶多酚溶液保存的异体神经能降低其移植后的免疫反应。绿茶多酚溶液保存的同种异体神经不但能较好地保留促进周围神经再生并有导向作用的神经膜管结构，而且供体的许旺细胞仍有少数存活，轴索在供体许旺细胞的帮助下可以成功长入远端。此外，1 mg/mL 的绿茶多酚溶液和 4的环境都比较容易获得，故绿茶多酚溶液保存法应有很好的临床应用前景。文章发表在中国神经再生研究（英文版） 杂志
3、2015 年 1 月第 1 期。Article: “ Allograft pretreatment for the repair of sciatic nerve defects: green tea polyphenols versus radiation,“ by Sheng-hu Zhou, Ping Zhen, Shen-song Li, Xiao-yan Liang, Ming-xuan Gao, Qi Tian, Xu-sheng Li (Orthopedics Center, Lanzhou General Hospital of Lanzhou Military Area Co
4、mmand of Chinese PLA, Lanzhou, Gansu Province, China)Zhou SH, Zhen P, Li SS, Liang XY, Gao MX, Tian Q, Li XS (2015) Allograft pretreatment for the repair of sciatic nerve defects: green tea polyphenols versus radiation. Neural Regen Res 10(1):136-140.欲获更多资讯：Neural Regen Res SICENCE 新闻发布 作者：周胜虎 稿号：NR
5、R_229_14Green tea polyphenols-pretreated nerve allografts for repair of peripheral nerve defects Sheng-hu Zhou, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, China and his colleagues recently found that sciatic nerve allograft pretreated with 1 mg/mL green tea polyphenols
6、 (GTP) at 4 was superior to irradiation-pretreated sciatic nerve allograft from the perspectives of functional and structural results in the repair of 1.0 cm-long sciatic nerve defect. The use of nerve allografts, however, is precluded by immunological rejection. Many attempts have been made to mini
7、mize immunological rejection, including hypothermia, freeze-drying, freeze-thawing, plasma immersion, and irradiation of the donor tissue. The mechanism underlying the effects of irradiation may be that X-rays destroy the antigen-secreting function of Schwann cells, thus promoting peripheral nerve r
8、egeneration through the retained neurilemma and neural canal. In addition, irradiation of the allograft can prevent the spread of pathogens after transplantation; however, the technique cannot prevent post-transplantation infection altogether, and postoperative infection is the leading cause of nerv
9、e allograft failure. There is growing evidence that green tea lowers blood sugar and cholesterol, and has anti-radiation, anti-tumor, anti-inflammatory, and neuroprotective effects. GTPs (C17H19N30) are the main active component of green tea. Ikeguchi et al. showed that GTP-preserved nerve allograft
10、s attenuated ischemic injury and immunological rejection after transplantation.GTP pretreatment not only retains the nerve membrane and canal structure in the allograft, allowing the promotion and guidance of peripheral nerve regeneration, but also allows the survival of some Schwann cells at the do
11、nor site; thus, neurites grow into the distal end of the defect with the assistance of the donor Schwann cells. The conditions required for GTP pretreatment are relatively simple and inexpensive to obtain, meaning that GTP preservation of nerve allografts is a promising method for the treatment of p
12、eripheral nerve injury. The relevant article was published in the Neural Regeneration Research (Vol. 10, No. 1, 2015).Article: “ Allograft pretreatment for the repair of sciatic nerve defects: green tea polyphenols versus radiation,“ by Sheng-hu Zhou, Ping Zhen, Shen-song Li, Xiao-yan Liang, Ming-xu
13、an Gao, Qi Tian, Xu-sheng Li (Orthopedics Center, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, Gansu Province, China)Zhou SH, Zhen P, Li SS, Liang XY, Gao MX, Tian Q, Li XS (2015) Allograft pretreatment for the repair of sciatic nerve defects: green tea polyphenols versus radiation. Neural Regen Res 10(1):136-140.SICENCE 新闻发布 作者：周胜虎 稿号：NRR_229_14
