1、 10 19 c9 147 2012 M 10c 0.05b# “ bF1 7“4 F 70 4 OAsP 0a0 7 O TaOla a rAb 4aB# 4 |FX z Z _ SESb k Z zrb Ls1 ! s? aH F a b,b aBa a ( B) )a C16-18 ? ( B ) a5 sda ( ) )a DJa Dda ( ) )aE1800 ) V Py ? s72Y i YV7 E siVV Yc DJad4 P zFx A4 Y?94 0 ; Y? 4T V CP-940 V7r9 AT E1800E? Y E1802E? Y ) 4|Y Za84% H# )
2、 ArT D %Z ? z l 1iTb) LTV |aBa 4 |F Z k PYxc0.5%60%? AF 4 |AF 4 |Ah 8D 2 S0 Sv 2K1 “ j 4 eZE S4/ G b ZE HPLCEc i e 9 Q 0c b eAoA Mc 0.25 mLmL-1 Y 0.05 molL-1Z )A -J?50 50 _o 302 nmbT j i 22j1140 gmL-1S =L1“ z l q100.13 RSD 0.90 b y eZE a V Lz V j 4 eb1oM j c rAM EEPJ10.3969/j.issn.1672-2779.2012.19.
3、099cI| 1672-27792012 -19-0161-032VBMJUZ“OBMZTJTPG(SBOJTFUSPO)ZESPDIMPSJEF4QSBZ2VBMJUZ“OBMZTJTPG(SBOJTFUSPO)ZESPDIMPSJEF4QSBZZhou Jifa1, Liu Ligen2(1 Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029,China; 2 China Pharmaceutical University, Nanjing 210029, China)Abstract: Obj
4、ectiveAbstract: Objective Granisetron hydrochloride spray quality control methods, to provide the technical basis for the development of quality standards. MethodsMethods HPLC determination of content, detecting the total spray times in each bottle and testing each spray drug content. The chromatogr
5、aphic column was cyanosilane bonded silica gel column; mobile phase containing 0.25% (mLmL-1) triethylamine in 0.05 molL-1 sodium acetate solution-methanol (50:50); detection wavelength: 302 nm. ResultsResults Granisetron hydrochloride in 22114gmL-1 concentration range was linear relationship, recov
6、ery 100.13 %, RSD 0.90 %. ConclusionsConclusions Established a reasonable method of quality control, reliable, reproducible and can be used for quality control of granisetron hydrochloride spray.Key words:Key words: Granisetron hydrochloride; Content determination; HPLC j B r4 5-HT3 s8 F4 “5W ?ba 0
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