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阿片耐受与慢性癌痛的阿片类药物治疗.pdf

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5、 NC9L B.e eBC h bN He $ 5 s H .YD1“b 0 sBC S%“98C 0 sS 9 i ; e gA NHNM P 0 s “ L0b j0*)kY 0 s0*)# “5VC ) y s8/.%“ s81 “5 VC 0 rh b 0 sM1 0*) j E v4 y 9 X0*)ro Ti *h .e S H 0 l4 /.%“ s8 F4 KD4 ? X 0 s0*) ? *e1& ba 0 s e V ?C Z4C izpsb 0 sVC “5D 3 0 s 0 e b 0 s 4 S.eD Chinese Journal of Pain Medicine

6、2012 ,18 , ( 9 )0*)kY “5 n5E eC 0 l4 /.%“ s8 F4 0 s0*)erTm)b ID1 Guignard B, Bossard AE, Coste C, et al. Intraopera-tive remifentanil increases postoperative pain and morphine requirement. Anesthesiology, 2000, 93 : 409 417.2 Garzn J, Rodrguez-Muoz M, Snchez-Blzquez P. Do pharmacological approaches

7、that prevent opioid tolerance target different elements in the same regulatory machinery? Curr Drug Abuse Rev, 2008, 1 : 222 238.3 Collett BJ. Opioid tolerance: the clinical perspecti-ve. Br J Anaesth, 1998, 81 : 58 68.4 Porter J, Jick H. Addiction rare in patients treated with narcotics. Engl J Med

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9、02, 22 : 8312 8323.7 Gardell LR, Wang R, Burgess SE, et al. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release fromm primary afferent fi bers. J Neurosci, 2002, 22 : 6747 6755.8 Vanderah TW, Suenaga NM, Ossipov MH, et al. Tonic descending f

10、acilitation from the rostral ventr-omedial medulla mediates opioid-induced abnorm-al pain and antinociceptive tolerance. J Neurosci, 2001, 21 : 279 286.9 Lotta T, Vidgren J, Tilgmann C, et al. Kinetics of human soluble and membranebound catechol O-methyltransferase: A revised mechanism and de-script

11、ion of the thermolabile variant of the enzyme. Biochemistry, 1995, 34 : 4202 4210.10 Li X, Clark JD. Hyperalgesia during opioid absti-nence: Mediation by glutamate and substance P. Anesth Analg, 2002, 95 : 979 984.11 Lee M, Silverman SM, Hansen H, et al. A comp-rehensive review of opioid-induced hyp

12、eralgesia. Pain Physician, 2011, 14 : 145 161.12 Bilsky EJ, Inturrisi CE, Sade W, et al. Competiti-ve and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice. Pain, 1996, 68 : 229 237.13 Kissin I, L

13、ee SS, Arthur GR, et al. Time course characteristics of acute tolerance development to continuously infused alfentanil in rats. Anesth Analg, 1996, 83 : 600 605.14 Elliott K, Kest B, Man A, et al.N-methyl-D-aspar-tate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic

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15、nduced hyperalgesia and tol-erance. Am J Ther, 2010, 17 : 498 510.18 DuPen A, Shen D, Ersek M. Mechanisms of opi-oid-induced tolerance and hyperalgesia. Pain Ma-nag Nurs, 2007, 8 : 113 121.19 Foley KM. What the cancer patient has taught us. Current and emerging issues in cancer pain: rese-arch and practice. Edited by Chapman CR, Foley KM. New York: Raven Press.1993, 331 350.c565cS.eD Chinese Journal of Pain Medicine 2012 ,18 , ( 9 )

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