1、Childhood and Adolescent Hypertension,James H. Moller, M.D. Professor and former Head of Pediatrics University of Minnesota Minneapolis Minnesota, 55455molle002umn.edu,Childhood and Adolescent Hypertension,Cardiovascular Disease Prevention,Childhood and Adolescent Hypertension,Trends during past 50
2、years- 1958-mostly “secondary” Primary considered rare. 2008-mostly “primary”, Secondary to obesity and lack of physical activity,Childhood and Adolescent Hypertension,Types of Cardiovascular prevention Primordial-Prevention of development of cardiovascular risk factors. Primary-Control cardiovascul
3、ar risk factors once they are present. Secondary-Reduction of risk factors once a cardiovascular event has occurred.,Childhood and Adolescent Hypertension,PDAY and Bogalusa StudiesFatty streaks in coronary arteries and aorta occur early in life. More advanced fibrous plaques in adolescents and young
4、 adults.,Childhood and Adolescent Hypertension,PDAY and Bogalusa StudiesRisk factors of high body mass index, high blood pressure, dyslipidemia strongly associated with extent of arterial lesions. Presence of multiple risk factors associated with higher risk of atherosclerotic lesions.,Childhood and
5、 Adolescent Hypertension,Long-term study of children first seen from 1922 to1935. Of adolescents with BMI greater than 75% relative risk of death from coronary heart disease is 2.3. Also higher morbidity from coronary artery disease.,Childhood and Adolescent Hypertension,Clustering of Cardiovascular
6、 Risk FactorsStroke associated with obesity and hypertension Obese children often have some degree of insulin resistance Insulin resistance syndrome occurs in children with truncal obesity, high triglycerides, low LDL-C, hyperinsulinemia,Childhood and Adolescent Hypertension,Evaluation of Children a
7、nd Adolescents History about physical activity, food choices, smoking, sleep disorders. Family history of early (under 55 years) of cardiovascular events or disease.,Childhood and Adolescent Hypertension,Evaluation of Children and Adolescents Careful and repeated measurement of blood pressure Measur
8、e height and weight-compare to growth charts Measure abdominal circumference Calculate body mass index (BMI) BMI=weight (kg)/height(M)squared,Childhood and Adolescent Hypertension,Blood Pressure Measurement All children over 3 years old in medical setting should have blood pressure measured. Auscult
9、ation preferred measurement method. Use appropriate sized blood pressure cuff. Elevated blood pressure measurement must be confirmed by repeat readings,Childhood and Adolescent Hypertension,Definition of Pre-hypertensionSystolic or diastolic blood pressure between 90% and 95% for gender, age and hei
10、ght on at least 3 occasions. Blood pressure above 120/80 on at least 3 occasions.,Childhood and Adolescent Hypertension,Definition of Hypertensionsystolic or diastole pressure above 95% for gender, age and height on at least 3 occasions.,Childhood and Adolescent Hypertension,Management of Normal BP
11、BP less than 90%. Measure BP on next regular medical visit. Encourage healthy food choices and physical activity. Medication-none.,Childhood and Adolescent Hypertension,Management of Pre-hypertension BP-90%-95% or greater than 120/80 Measure BP again in 6 months. Weight management if obese. Counsel
12、on food choices and physical activity Medications-none,Childhood and Adolescent Hypertension,Management of Hypertension BP 95%-99% Measure BP in 2 weeks Management-food choices and physical activity Medication if persistent high BP, symptomatic, diabetes or secondary,Childhood and Adolescent Hyperte
13、nsion,Clustering of Cardiovascular Risk FactorsMeasure fasting lipid profile and blood glucose and A1C level in pre-hypertensive obese children, all children over 95% blood pressure,Childhood and Adolescent Hypertension,Management of Elevated Blood Pressure. Medication Indication-secondary hypertens
14、ion, insufficient response to life style modification. Medication-initially a single drug. Goal-reduction of blood pressure below 90%.,Childhood and Adolescent Hypertension,Management of Elevated Blood Pressure in Children. Most patients with high BP-treatment is life-long. Long-term consequences of
15、 untreated hypertension in children-unknown. Long-term consequences of medication effects in children-unknown. Therefore, definitive indication is needed before beginning medication.,Childhood and Adolescent Hypertension,Management of Elevated Blood Pressure in Children. Medication Diuretics and bet
16、a-blockers in children have a long history of safety and efficacy. Remain appropriate for use in children and adolescents.,Childhood and Adolescent Hypertension,Adult blood pressure correlates with: childhood blood pressure, body size, Change in ponderosity between childhood and adulthood.,Childhood
17、 and Adolescent Hypertension,In childhood, the magnitude of change in blood pressure related to amount of ponderosity gain or loss and does not depend on initial blood pressure. Thus, for obese children weight loss may be effective method for reducing blood pressure.,Changes in BMI and Systolic BP i
18、n Minneapolis School Children Between 1986 & 1996,1986,1996,18.5,19,19.5,20,20.5,21,21.5,Male,Female,kg/m2,BMI,P.0001,P.0001,102,104,106,108,Male,Female,mm Hg,Systolic BP,P.0001,P=.0002,Childhood and Adolescent Hypertension,Chinas division of KFC, Pizza Hut, and Taco Bell profits increased 33% last
19、year. KFC-2,500 restaurants in 450 cities. KFC projects 14,000 restaurants in China-more than number of McDonalds restaurants in the US.,Childhood and Adolescent Hypertension,5-2-1-0 Principle 5 fresh fruits or vegetables/day 2 hour limit of screen time/day 1 hour physical activity/ day 0 sweetened
20、drinks (sodas)/day,Childhood and Adolescent Hypertension,The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in children and Adolescents. Pediatrics 2004;114;555-576,Childhood and Adolescent Hypertension,American Heart Association Guidelines for Primary Prevention of
21、 Atherosclerotic Cardiovascular Disease Beginning in Childhood. Circulation 2003:107:1562-1566,Childhood and adolescent Hypertension,Cardiovascular Health in Children. A Statement for Health Professionals from Committee on atherosclerosis, Hypertension and Obesity in the Young. American Heart Association Circulation 2006: 106:143-160,
