1、This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller
2、and DS18B20 temperature sensor.Hepatitis B Virus1This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core comp
3、onents of the system are AT89C51 microcontroller and DS18B20 temperature sensor.乙型肝炎病毒2This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and si
4、ngle chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.3This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital t
5、emperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.无症状携带者无症状携带者重症肝炎重症肝炎急性肝炎急性肝炎慢性乙肝慢性乙肝与肝硬化和肝癌密切相关HBV感染的临床类型4This paper mainly introduces the design of an intelligent temperature control system which r
6、ealizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.HBV流行久远、传播广泛流行久远、传播广泛 ，是全球性公共卫，是全球性公共卫生问题：全球生问题：全球 3.5亿人携带亿人携
7、带 HBV我国为高流行区我国为高流行区感染率感染率 60% HBsAg携带率携带率 8%-10%慢性乙肝病人慢性乙肝病人 1000万万80%原发性肝癌与原发性肝癌与 HBV慢性感染有关慢性感染有关 乙型肝炎病毒5This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature se
8、nsor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.6This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using s
9、ingle bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2003年张先乙肝歧视事件乙肝歧视引发社会问题7This paper mainly introduces the design of an intelligent temperature control system which realizes the fun
10、ction of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2003年周一超杀人事件8This paper mainly introduces the design of an intelligent tempe
11、rature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9This paper mainly introduces th
12、e design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.
13、p1965年 Blumberg首次报道澳大利亚土著人血清中一种与肝炎相关抗原，称为澳大利亚抗原或肝炎相关抗原（ HAA），随后证实是 HBV的表面抗原p1970年 Dane电镜下发现患者血清中存在 HBV颗粒HBV发现史10This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperat
14、ure sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor. 致病性与免疫性：1.传染源p乙肝患者 （潜伏期 30-160天，急性期及慢性活动期）pHBsAg携带者 (约 10%，人群感染率 60%)2.传染途径p血液、血制品等传播p母婴垂直传播p性接触及密切接触传播HBV致病性与免疫性11This paper mainly introduces the design o
15、f an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.临床表现pAcute
16、 infection急性肝炎pFulminant hepatitis暴发型肝炎 pChronic infection 慢性肝炎pPrimary hepatocellular carcinoma （PHC）原发性肝细胞癌 12This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperat
17、ure sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.13This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by
18、using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p致病机理（确切机制尚不明确） HBV在肝细胞内长期感染。 HBV DNA整合于细胞染色体。 免疫病理损伤导致症状发生。HBV致病性与免疫性14This paper mainly introduces the design of an intell
19、igent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p细胞免疫及其介导的免疫病理损害u细胞免疫
20、nCTL直接杀伤n分泌细胞因子发挥增强免疫应答nCTL诱导细胞凋亡u免疫损伤n免疫过强 -重症肝炎n免疫过弱 -慢性肝炎HBV致病性与免疫性15This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip micro
21、computer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p体液免疫介导的免疫病理损害u体液免疫n抗 -HBs：中和抗体n抗 -PreS1及抗 -PreS2：阻断 HBV吸附于肝细胞n抗 -HBe和抗 -HBc无保护作用u免疫损伤nHBsAg和抗 -HBs形成免疫复合物，激发 III型超敏反应n肝内损伤（重症肝炎）n肝外损伤（肾小球肾炎、关节炎） HBV致病性与免疫性16This paper mainly introduces the design
22、 of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p自身免疫介导的
23、免疫病理损害u诱导肝细胞自身抗原暴露u体液免疫和细胞免疫杀伤u慢性肝炎患者血清中常可检测到 LSP抗体、抗核抗体、抗平滑肌抗体 HBV致病性与免疫性17This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip m
24、icrocomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p免疫耐受与慢性肝炎uHBV感染者细胞免疫和体液免疫处于较低水平或完全缺失u不能清除病毒，也不能有效形成免疫应答杀伤靶细胞，形成免疫耐受u临床表现为无症状 HBV携带者和慢性持续性肝炎HBV致病性与免疫性18This paper mainly introduces the design of an intelligent temperature control system whic
25、h realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.p机体对 HBV的免疫效应具有双重性，清除病毒和损伤肝细胞p免疫功能正常 -急性肝炎p免疫功能过强 -重症肝炎p免疫
26、功能低下 -慢性肝炎HBV致病性与免疫性19This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT
27、89C51 microcontroller and DS18B20 temperature sensor.p病毒变异与逃逸u诊断逃逸nA抗原表位基因突变 -a抗原性改变，现有诊断方法不能检测出 HBsAgu免疫逃逸npreC基因突变，不能翻译出完整 HBeAg，逃避免疫清除nC基因突变， HBcAg抗原位点改变，逃避 CTL杀伤u耐药性逃逸nP基因突变，耐药性变异，逃避抗病毒药物杀伤 HBV致病性与免疫性20This paper mainly introduces the design of an intelligent temperature control system which rea
28、lizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.pHBV与原发性肝癌pHBV与原发性肝细胞癌（ HCC）关系密切pX基因编码的 X蛋白，反式激活和多种生物学作用影响肝细胞细胞
29、周期，促进细胞转化，最后发展成 HCCHBV致病性与免疫性21This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the syst
30、em are AT89C51 microcontroller and DS18B20 temperature sensor.p There are 3 particles in patients bloodp Dane particle Dane颗粒（大球形颗粒）p small spherical particle小球形颗粒p tubulose particle管形颗粒1.形态结构形态结构乙型肝炎病毒22This paper mainly introduces the design of an intelligent temperature control system which reali
31、zes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.23This paper mainly introduces the design of an intelligent tempe
32、rature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.大球形颗粒（ Dane particle） 完整的，具有感染性的
33、 HBV，球形，双层衣壳。outer capsid=envelope外衣壳 =包膜 (脂质双层 +包膜蛋白 ) HBsAg等 inner capsid内衣壳： HBcAg、 HBeAgCore 核心： DNA- circular, double- stranded环状双链DNA polymerase 多聚酶24This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and
34、control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.Dane颗粒的结构外层外层 病毒包膜，病毒包膜， 脂质双层脂质双层 +包膜蛋白包膜蛋白S蛋白（蛋白（ HBsAg）包膜蛋白包膜蛋白 M蛋白（蛋白（ HBsAg+PreS2Ag）L蛋白（蛋白（ HBsAg+PreS2Ag+Pre
35、S1Ag） 内层内层 病毒的核衣壳，病毒的核衣壳， 20面体对称面体对称 含含 HBcAg核心核心 双股环状未闭和双股环状未闭和 DNA和和 DNA多聚酶多聚酶大球形颗粒（ Dane particle） 25This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sens
36、or DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.HBV的小球形颗粒过剩的衣壳蛋白装配而成主要是 HBsAg，没有感染性26This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature
37、measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.HBV的管形颗粒小球形颗粒串联而成27This paper mainly introduces the design of an intelligent temperature control
38、system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.28This paper mainly introduces the design of an
39、 intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.29This paper m
40、ainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.基因组为不完全双链环状 DNAp长链（负链） ： 长度固定， 3200bp p短链（正链） ： 长链的 50%-100% p负链含 4个 ORF： S区、 C区、 P区、 X区2、 HBV的基因结构与功能30
