1、This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller
2、and DS18B20 temperature sensor.子宫内膜异位症对 IVF结局的影响北京大学人民医院生殖医学中心沈浣This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer
3、. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2018/9/18子宫内膜异位症影响 IVF周期结局？ 早年的研究认为 ，内 异症会降低受精率、移植率、和妊娠率 。 Barnhart 2002： meta分析， 27个研究， 1983 1998 内异症受孕率低于卵管因素组 (OR: 0.56; 95%CI: 0.44 to 0.70). 受精率 an、种植率、获卵数也低。值得注意的是， 2组的种植率和妊娠率均低。 (12.72% vs 18.08%) 近
4、年的数据提示内异症患者的 IVF结局与对照组没有不同This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system ar
5、e AT89C51 microcontroller and DS18B20 temperature sensor.子宫内膜异位症影响 IVF周期结局？N IVF周期数 分娩率内膜异位 241 360 30%输卵管因素 111 166 37.5%2018/9/18Olivennes ：内异症 vs 卵管因素， 分娩率 无统计学意义差异。This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature meas
6、urement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.子宫内膜异位症影响 IVF周期结局？ Omland AK,2005：大样本回顾研究： 内异 症 vs 卵管因素，live-birth rate相似 ， 66.0% vs 66.7%。 明显 低于不明原因
7、不孕组： live-birth rate78.8%。 移植率： 3组间无差异。2018/9/18This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core compo
8、nents of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2018/9/18子宫内膜异位症影响 IVF周期结局？2010 SART registry内异症 VS总的不孕患者，年龄分层， IVF治疗结局无差异This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and con
9、trol by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2018/9/18子宫内膜异位症的期 别对 IVF结局的影响高期别的子宫内膜内异症，可能降低颗粒细胞雌孕激素受体的表达。This paper mainly introduces the design of an intelligen
10、t temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.This paper mainly introdu
11、ces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature s
12、ensor.This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontr
13、oller and DS18B20 temperature sensor.子宫内膜异位症的期别对 IVF结局的影响 Kurt Barnhartt， meta分析：内异症 重度 vs 轻度： HCG日雌激素水平，获卵数，妊娠率都 2018/9/18This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digit
14、al temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.子宫内膜异位症的期别对 IVF结局的影响2018/9/18Kuivasaari， 2005：虽然年轻， III/IV 较 I/II期和卵管因素组移植率明显减低 。This paper mainly introduces the design of an intelligent tempera
15、ture control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.深部侵润病灶对 IVF结局的影响 Ballester， 2012：
16、DIE与表面的 EM比较，妊娠率低 (58% 、vs 83%; p =0.003)，妊娠的强预测值，高于年龄、 AMH、AFC2018/9/18This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip micro
17、computer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2018/9/18卵巢子宫内膜异位 囊肿对 IVF结局的影响 Yanushpolsky ： 卵巢子宫内膜异位症患者的流产率高，获卵数少，胚胎的质量差。 相反 Olivennes 认为 ， endometriomas 对结果没影响。This paper mainly introduces the design of an intelligent temperature control syst
18、em which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2018/9/18卵巢子宫内膜异位 囊肿对 IVF结局的影响 一些 学者则认为：巧囊患者的卵巢反应不良
19、，需要大剂量的 GN刺激；然而不影响累积妊娠率和活产率 。 Ballester：回顾 性 研究， 巧 囊数目 ， 病灶大小，单 侧 或双侧 对结果都没有影响 。 但深部侵润病灶对累积妊娠率有明显的影响。强调对治疗前对卵巢功能的评估。This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temp
20、erature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018超长方案是否能改善妊娠的结局 ? 传统的内异症药物治疗包括：孕激素，达那唑， GnRH-a等，但对于提高自然妊娠率效果并不好 停药后内异症对妊娠的影响迅速反复 妊娠的最佳时期 药物对内异症起到最大抑制作用时 只有辅助生殖技术可以做到This paper mainly introduces
21、 the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sens
22、or.超长方案相关研究Nakamura K 超 长方案组（ n=21)：至少 2个月 GnGHa 长方案组（ n=11）： 黄体期 长方案 评价指标：激素的反应性，获卵数，受精卵数，卵裂数，移植胚胎数均相似。临床妊娠率超长方案明显高于对照组 (67 vs 27%)9/18/2018This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by usin
23、g single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018Marcus SF, Edwards RG. n=84(181个周期 )，半随机对照前瞻试验， 对象：重度子宫内膜异位症患者 (grades III and IV)重度子宫内膜异位症患者接受超长方案治疗可以获得高的妊娠率。 超长方案相关研
24、究GnRH-a短方案+HMG+HCGn=69超长方案 2-7个月n=15p值临床妊娠率（%）11 35每移植周期妊娠率（%）12.7 42.8 P0.001This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip
25、 microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.超长方案相关研究 Remorgida V 比较轻度子宫内膜异位症 患者 ， 不同 促排方式 对 GIUI的 影响 （ I-II期）患者，使用 3种不同促排方式： 方案：促排之前使用 6个月 GnRH-a，GnRH-a和外源性 GN同时使用。对照组只使用 GN 样本量 N=60妊娠率： 1组 =56%； 2组 =32%； 3组 =33%， 2组与 3组无差异，而 1组明显高于其它
26、2组。结论：促排卵之前，应用超长方案能 改善异 症不孕患者的妊娠率 。9/18/2018This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core component
27、s of the system are AT89C51 microcontroller and DS18B20 temperature sensor.超长方案相关研究Dicker D 评价 IVF-ET治疗重度子宫内膜异位症前应用超长方案的意义。 31名中 -重度子宫内膜异位症患者，前次 IVF-ET周期失败，此次治疗前先使用 GnRH-a超长方案降调后，再行 IVF-ET，获卵数明显增高 (P 0.0006); 胚胎移植率和临床妊娠率都明显提高 (P0.0001)。9/18/2018This paper mainly introduces the design of an intellige
28、nt temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.超长方案相关研究 Surrey比较了长方案和超长
29、方案的不同疗效，结果证实后者的妊娠率高于前者。研究对象： 手术证实的 EM患者 试验组： IVF超促排卵之前使用 3个月 GnRH agonist对照组：没用超长方案，直接进入周期outcome：超长方案组，持续妊娠率显著提高，同时移植率也有提高。 更值得一提的是，试验组的内异症分期更高，而高期别的患者妊娠结局本应更差。9/18/2018This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature me
30、asurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018超长方案相关研究 *显著差异 * * *有升高趋势，但无显著差异Modified from Surrey et al.This paper mainly introduces th
31、e design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.
32、9/18/2018Rickes一项前瞻试验（ n=110），对比了 单纯手术治疗 +IVF/IUI vs 手术 +术后辅助 6个月的 GnRH-a+IVF/IUI 二组的结局。结果：不论那种助孕方式， IVF or IUI，辅助 6个月的 GnRH-a后，妊娠率都显著提高。然而，当把病人按内异症分期划分层次再比较时发现：只有 IVF治疗的 III/IV期患者，超长方案的优势才有统计学意义。This paper mainly introduces the design of an intelligent temperature control system which realizes the
33、function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.超长方案相关研究 Sallam Cochrane Database的 3个前瞻随机试验164名内异症患者，进入周期前，接受 3-6个月的超长方案治
34、疗。 结果显示：活产率 /妇女 (OR:9.19; 95% CI, 1.08 to 78.22)临床妊娠率 /妇女 (OR: 4.28;95% CI, 2.0 to 9.15)Sallam HN, Cochrane Database Syst Rev 2006;(1):CD0046359/18/2018This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and cont
35、rol by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018In Vitro Fertilization and Endometriosis: Prolonged Pre-Cycle Gonadotropin-Releasing Hormone AgonistThis pap
36、er mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18
37、B20 temperature sensor.9/18/2018进一步研究 用药时间？ 适用人群？ 需要考虑经济负担增加及妊娠时间延后This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcompu
38、ter. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018GnRHa可能的作用机制 减少腹腔液金属蛋白酶组织抑制因子聚集，降调腹腔液炎性蛋白，增加凋亡和促凋亡调节蛋白的表达Sharpe-Timms KL,Ferrero S,Bilotas M GnRHa增加子宫内膜一氧化氮合酶Wang J, Fertil Steril 2006;85(4):10371044This paper mainly introduces the design of
39、 an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018Gn
40、RH可以增加整合素 3的表达 对子宫内膜异位症 I/II期和内膜整合素 3表达异常的患者，应用 GnRH-a后，有 64%患者可以恢复该蛋白表达。Lessey BA.Fertil Steril 2000;73(6):10891096 鼠模型，发现因卵巢刺激，造成子宫内膜整合素 3及内膜容受性降低，而通过 GnRHa，可以修复部分损伤。Ruan HC, Hum Reprod 2006;21(10):25212529This paper mainly introduces the design of an intelligent temperature control system which r
41、ealizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018寻找一种标记物 3整合素，来预测超长方案的适宜人群 并不是所有的内异症患者等都需要超长方案的干预。 近年
42、来，学者们寄期望于 3整合素，期望它的表达是能成为一种标记物，预测怎样的患者更适于 GnRH-a超长方案的治疗。 This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The c
43、ore components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018Surrey 随机前瞻试验。N=36检测 3 整合素的表达后随机分组GnRHa组： 3个月 GnRHa后 COHcontrol组：直接进入周期结果 ：整合素阳性的患者，使用超长方案后，妊娠率提高，但差异无统计学意义。整合素阴性的患者， GnRHa组的妊娠率仅为 44.4%,低与对照组整合素能预测 GnRHa的适用人群吗？This paper mainly introduces the design of
44、 an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.9/18/2018整合
45、素能预测 GnRHa的适用人群吗？ 该试验并没有得到我们想要的结果：整合素并不是理想的使用 GnRHa人群的预测因素试验受样本量的限制评估整合素时所做的内膜活检有增加内膜种植率的效果，而 GnRH组没有受益Surrey ES, Fertil Steril 2010;93(2):646651Barash A, Fertil Steril 2003;79(6):13171322Raziel A, Fertil Steril 2007;87(1):198201This paper mainly introduces the design of an intelligent temperature c
46、ontrol system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.超长方案的其它应用 前次 IVF失败的正常反应患者超长方案 长方案Gn天数 10.94 9.4Gn总量 27.76 26.73获卵数 10.12 16受精率 80.8 74.42卵裂率 93.54 98.31临床妊娠率 46.15（ 6/13） 0
