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类型先心病病人非心外手术的麻醉.ppt

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    先心病病人非心外手术的麻醉.ppt
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    1、Anesthesia for the Patient With Congential Heart Disease For Non Cardiac Surgery,Ri 許逵翔/蔡易臻/羅偉成/ CR 章宏吉/ V.S. 黃啟祥,Background,Continuous improvement in medical care and surgical treatment longer the lifespan of congential Heart Disease (CHD) patient 1.2 million adults (16 years) living with various f

    2、orms of CHD in the U.S.,The recommendations -How to care CHD patient?-,Centers that have multi-disciplinary CHD programs and staffEvery pediatric cardiology program in the center should identify a specialized, dedicated CHD program for the transition of their patients. 這是過渡期(兒童期) 須有小兒心臟專家Patients wi

    3、th moderate or severe ACHD should be transferred to a dedicated ACHD program for urgent or acute care,For Anesthesia -How to care about CHD patient?-,Dedicated cardiac anesthesia team with expertise in the management of CHD Well consultative services and interacts at all levels,Who is actually repai

    4、red?,Very few types of congenital heart disease are truly fixed with no residual problems Except : PDA ligation Uncomplicated secundum ASD Uncomplicated VSD,Pathophysiology of chronic CHD,ventricular overload repeated myocardial ischemia altered coronary artery supply chronic hypoxemia inadequate my

    5、ocardial protection Alter normal development of cardiovascular system Consequences of Congenital Heart Disease,Consequences of Congenital Heart Disease,CHF Hypoxemia, cyanosis Polycythemia Pulmonary vascular disease Previous surgical sequence Alter normal growth and cardiovascular development,Key in

    6、 approaching the CHD patient,Most important consideration in approaching the patient : potential to develop or exacerbate low systemic cardiac outputThe other possible risk factors : contractile dysfunction the pressure- or volume-loaded ventricle pulmonary hypertension end-organ dysfunction,Atrial

    7、septal defect,most successful ASD repairs carry little risk of late complications However, if the defect closed late pulmonary hypertension may develop in 2030 years Persistent atrial arrhythmias,Ventricular Septal Defect,If the VSD is non-complicated the defect is closed early no residual VSD of si

    8、gnificance no associated lesions ex. outflow obstruction, subaortic membrane, heart block Function are likely to be normalHowever, in complicated patient LV dysfunction, pulmonary hypertension may developed,Aortic Coarctation,Persistent systemic hypertension independent of any residual obstruction l

    9、ikely due to changes in SVR in response to the presence of a coarctation Most common in older children Recurrent stenosis Most common in infant(20%), few by age 3 years(1%) LV hypertrophy Increased risk of sudden death,Atrioventricular Canal Defects,These patients have large left-to-right shunts, ex

    10、cessive pulmonary blood flow CHF Pulmonary hypertension The most common problems after repair valvar regurgitation (especially mitral) residual VSD occasionally pulmonary hypertension,TETRALOGY OF FALLOT,Park: Pediatric Cardiology for Practitioners, 5th ed.,Tetralogy of Fallot,Kliegman: Nelson Textb

    11、ook of Pediatrics, 18th ed.,http:/ Aorta,PA stenosis,Large VSD,RV hypertrophy,Tetralogy of Fallot,Park: Pediatric Cardiology for Practitioners, 5th ed.,Palliative procedures,Central shunt,Tetralogy of Fallot,Park: Pediatric Cardiology for Practitioners, 5th ed.,Total correctionRepair VSD, PA stenosi

    12、s,“Fixed but not cured” Major problem Abnormal RV loading (pressure & volume) Obstruction of RV outflow tract (RVOT) reconstruction,Rastelli procedurefor TGA with pulmonary stenosis,Tetralogy of Fallot,Park: Pediatric Cardiology for Practitioners, 5th ed.,Pulmonary atresia,Truncus arteriosus,Tetralo

    13、gy of Fallot,Major problems following TOF repair Progressive RV dysfunction Predictor of late morbidity and mortality Decreased exercise tolerance Image tools Development of ventricular arrhythmias Unknown of prognostic significance Indication for ablation, antiarrhythmic agents, or an implantable c

    14、ardioversion-defibrillator (ICD) Increased risk of sudden death,Tetralogy of Fallot,Cardiac MRI useful tool RV systolic function RV volume Degree of PR (not readily quantified by any other technique) Image potential sites of RVOT obstruction,http:/kjronline.org/abstract/journal_figure.asp?img=05-AB.

    15、JPG&no=206&desc=desc6,Tetralogy of Fallot,Factors reduced long-term survival Older age (4 years) at repair Initial palliative shunting procedures Especially central shunt Significant residual RV hypertension RV:LV 0.5-0.75; RVOT obstruction, PA stnosis Volume loading of the RV,Tetralogy of Fallot,Di

    16、fficult to accurately predict Defining their risk factors for and their degree of RV dysfunction Positive pressure ventilation (RV afterload and RV filling ) to decrease cardiac output in patients with significant PR and RV dysfunction Dysfunctional RV to compromise systemic cardiac output (via decr

    17、eased RV output, as well as ventricular interdependence causing decreased LV filling and function)Optimizing and maintaining RV function !,Positive pressure ventilation,PVR ,PR,RV dysfunction,Intrathoracic Pressure ,CO,Tetralogy of Fallot,Peri-OP Optimizing and maintaining RV function Avoided factor

    18、s that increase PVR Especially in free PR and RV dilation Maintained RV filling But excessive volume loading may also be poorly tolerated Avoided drugs that significantly diminish RV contractility Keeping heart rate approximately normal Maintaining RV oxygen delivery by maintaining blood pressure an

    19、d oxygen carrying capacity Prevent tachycardia, hypotension, acidosis, and anemia,Tetralogy of Fallot,Post-OP Invasive monitoring and postoperative care in an ICU setting “Prophylactic” administration of inotropes to improve RV contractile,TRANSPOSITION OF THE GREAT ARTERIES (TGA),Transposition of t

    20、he Great Arteries,http:/ Nelson Textbook of Pediatrics, 18th ed.,Transposition of the Great Arteries,Atrial baffle operation Atrial switchMustard or Senning operationPhysical repair,TGA Atrial Switch,Reasonable functional status and fairly normal lives into their 3rd and 4th decade 15-20 year surviv

    21、al : 80-85% Long term Progressive deterioration of RV function Development of TR Signs and symptoms of right heart failure Arrhythmias (Ventricle & atrial) (tachycardia or SSS) Sudden death,TGA Atrial Switch,Baffle leak Intra-atrial shunting and hypoxemia Baffle obstruction of the systemic venous re

    22、turn Superior vena cava syndrome, hepatic congestion, ascites, and peripheral edema Protein-losing enteropathy (PLE) (alb 3 mg/dl) Decreased RV function, decreased cardiac index, and increased systemic venous pressure Baffle obstruction of the pulmonary venous side Pulmonary edema or the development

    23、 of pulmonary hypertension,Baffle,Transposition of the Great Arteries,Arterial switch Since 1975, Jetene,Park: Pediatric Cardiology for Practitioners, 5th ed.,http:/radiology.rsnajnls.org/cgi/content-nw/full/247/3/617/F10,TGA Arterial Switch,Anatomical repair Early hospital mortality 97-98% Arterial

    24、 switch operation the preferred procedure in most centers,TGA Arterial Switch,Complication Small incidence of supravalvar pulmonary arterial and aortic stenosis at the anastomotic sites Can frequently be addressed by balloon dilatation. Neoaortic valve (the anatomic pulmonary valve) regurgitation (2

    25、5-30%) Coronary ostial lesions (3-5%) No evidence of myocardial ischemia,Anesthesia and Fontan Physiology,Fontan operation(1968),Indication: patient of severe tricuspid atresia, hypoplastic left heart syndrome, etc.,http:/www.inova.org,Physiology of Fontan patient,Red: artery Blue: vein,Transpulmona

    26、ry gradient(TPG)= CVP - LVEDP 5-8 mm Hg,Underlying diseases in patient s/p Fontan operation,Protein loss enteropathy(315%) Life-long stroke rate(23%) Thromboembolism(2030%) Arrhythmia(60% after OP 10 years) Venous pressure elevation Significant stasis of RA flow Increased pulmonary venous resistance

    27、 Myocardialdysfunction,Stamm et al., J Thorac Cardiovasc Surg 2001;121:28,Pre-OP assessment for Fontan Patient,Objective factors: NYHA class, heart rate response, delayed recovery from peak exercise Echocardiography for heart function Possible radiofrequency ablation for arrhythmia CVC monitor: veno

    28、us filling, pulmonary artery pressure, mixed venous oxygen saturationMay do CVC under image guidance,Penny et al Br Heart J 1991;66:372 Gewillig et al. J Am Coll Cardiol 1990;15:1424.,Peri-OP monitor for Fontan patient-1,Avoid large afterload and keep adequate preload Increased bleeding risk due to

    29、collateral vessels and high venous pressure Available pacemaker and defibrillator for arrhythmia Possible inotropic agent use: dopamine or Milrinone (Primacor, 0.25ug/kgmin),Dawit T. from Mayo Clinic, Pediatric Anesthesia,29 Feb 2008,Peri-OP monitor for Fontan patient-2,Positive ventilation: low mea

    30、n airway pressures (15-20 mm Hg), low ventilation rate with tidal volume(20ml/Kg), no PEEP use mild hyperventilation Nebulized pulmonary vasodilator: e.x.: Prostacyclin, NO, epoprostenol continuous use to lower pulmonary venous resistance,Peri-OP monitor for Fontan patient-3,Follow-up ABG: alkalizat

    31、ion blood using sodium bicarbonate to minimize mean airway pressures“Hypovolemia and increases in pulmonary vascular resistance are poorly tolerated by patients who have had a Fontan procedure. “ From Clinical Anesthesia Procedures of the Massachusetts General Hospital,Post-OP care for Fontan patien

    32、t,Fenoldopam use to increase mesentary and renal blood flow for maintaining end-organ function Heparin use for prophylaxis of thromboembolism Hydration for adequate preload,Take home message,TOF Preserve RV function TGA Obstruction of repair site Arterial switch need further follow-up data Fontan pa

    33、tient: Hypovolemia and increases in pulmonary vascular resistance were major points in anesthesia.,Thank you,Reference,Anesthesia for the Patient With Congenital Heart Disease For Non Cardiac Surgery Park: Pediatric Cardiology for Practitioners, 5th ed. Kliegman: Nelson Textbook of Pediatrics, 18th ed. http:/ http:/kjronline.org/abstract/journal_figure.asp?img=05-AB.JPG&no=206&desc=desc6 http:/ http:/radiology.rsnajnls.org/cgi/content-nw/full/247/3/617/F10 Anesthesia for Cardiac Surgery, 3rd ed.,

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