1、,SciFinder Web 新平台，新内容，新功能,SciFinder Web使用介绍,提纲,介绍 SciFinder Web中的内容 SciFinder Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,2,CAS is a division of the American Chemical Society. Copyright 2011 American Che
2、mical Society. All rights reserved.,美国化学文摘社Chemical Abstract Service,3,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,创建于1907年 ACS的分支机构 密切关注，索引和提炼着全球化学相关的文献和专利 最早创立了化学文摘 总部坐落于俄亥俄州的哥伦布市,SciFinder Web中的内容,4,CAS is a division of the Am
3、erican Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,期刊,专利,论文,会议报告,溶剂，催化剂，产率,反应实验过程等,物质,基因,合成信息,SciFinder Web中的内容,5,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提纲,介绍 SciFinder Web中的内容 SciFinder
4、Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,6,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder Web的注册和登陆,7,CAS is a division of
5、the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,SciFinder Web的系统要求 Windows用户支持IE 7.x或者FireFox 2.x Mac 用户支持 Firefox 和 Safari Java 安装（初次使用结构时自动安装） 在图书馆相关页面上找到SciFinder Web注册用的网址,Java插件的下载 http:/ 或者百度，google中搜索“JAVA下载”即可,点击URL创建SciFinder Web账号,8,CAS is a di
6、vision of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,开始创建SciFinder Web帐号,设置用户名及密码注意事项,用户名：必须是唯一的，且包含 5-15 个字符。它可以只包含字母或字母组合、数字和/或以下特殊字符：-（破折号） _（下划线) . （句点） （表示“at”的符号）密码：必须包含 7-15 个字符，并且至少包含三个以下字符：字母 混合的大小写字母数字 非字母数字的字符（例如 、#、%、&、*）,9,CAS is a divi
7、sion of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,密码设置小技巧： 1：不要和账号中有重复的字符 2：密码格式最好是abc123,对新ID的Email确认,10,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,需要点击邮件中的确认链接,Http:/scifinde
8、r.cas.org,Http:/origin-scifinder.cas.org,SciFinder Web登陆界面,11,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,输入SciFinder帐号和密码,SciFinder Web登陆后主界面,12,CAS is a division of the American Chemical Society. Copyright 2011 American Chemica
9、l Society. All rights reserved.,文献，物质，反应检索入口，默认开始检索文献,可用的检索方法,保存过的结果集,邮件提醒结果集,检索完，请点击退出,提纲,介绍 SciFinder Web中的内容 SciFinder Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web 中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,13,CAS is a division of the American
10、Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Scifinder web文献检索,胶囊的质量检测方法 quality identification of capsules,14,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提前限制出版年限、文献类型、语言等,主题词之间用（of, with, in
11、)等介词连接,主题检索候选项,15,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,各选项含义： “as antered” 表示完全匹配 “Concepts”表示对主题词做了同义词的扩展 “Closely associated with one another”表示同时出现在一个句子中 “were present anywhere in the reference”表示同时出现在一篇文献中,Scifinder we
12、b文献检索结果,16,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,全文链接,文献分析和限定工具,物质及被引用的文献链接,文献排序工具,工具栏,Sort by 文献结果的排序功能,17,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,
13、4种排序方式，可以按照登陆号、作者名、引文排序、出版年限、标题对文献检索结果进行重新排序,Citing References 引文排序,18,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,快速获得被引用次数最多的文献，查看具有参考价值的文献,12种文献分析工具,Index Term 索引词分析,19,CAS is a division of the American Chemical Society. Copyr
14、ight 2011 American Chemical Society. All rights reserved.,快速了解文献研究的主要内容，精选文献,Publication Year 出版年限分析,20,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Natural Order 出版年限排序,了解该领域的研究历史和发展,21,CAS is a division of the American Chemical
15、Society. Copyright 2011 American Chemical Society. All rights reserved.,组织机构分析： 了解潜在的竞争者、合作伙伴,作者分析： 发现本领域、课题的主要研究人员，以及同行评审专家,来源期刊分析： 发现相关的学术期刊，快速定位投稿期刊,Refine 文献的限定工具,22,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,六种限定工具，包括主题词、作者
16、姓名、机构名称、出版年代、语言、所属数据库,文献类型,专利,综述,综述、专利类文献,23,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,历史导航条，返回原先的检索界面,Categorize 系统分类功能,24,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All right
17、s reserved.,快速筛选不同学科的相关文献,Categorize系统分类功能,25,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,一级目录,二级目录,和二级目录有关的Index Term,TLC HPLC 反相HPLC 萃取等多种分析方法,点击标题查看文献的详细信息,26,CAS is a division of the American Chemical Society. Copyright 2011
18、American Chemical Society. All rights reserved.,摘要信息,物质结构,快速查看文献内容,27,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,摘要信息,重要概念索引,物质信息,专利号,文献结果保存,28,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical
19、 Society. All rights reserved.,使用Export将结果输出,Citation manager: 保存成RIS格式，用于导入EndNote等文献管理工具Offline Review:保存过成PDF，RTF格式，用于脱机浏览,文献检索小结,主题检索时，使用介词作为连接 尽量选择包含Concept和Closed Associated with的候选项 通过SciFinder 的Analyze/Refine功能来缩小检索的范围 尝试将不同的Analyze/Refine功能组合起来用，会有更多的收益 使用Categorize可以让系统来实现自动分类更多细节化内容，请参考 i
20、s a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,提纲,介绍 SciFinder Web中的内容 SciFinder Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,30,CAS is a divi
21、sion of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Scifinder web 物质检索,31,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,化学结构检索 Markush检索 分子式检索 性质检索 物质标示符检索,双击打开绘图面板,Substance Identi
22、fier 物质标示符检索,32,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,可以输入物质的名称，CA号，俗名，商品名，来进行检索,市场上的海带看起来碧绿鲜嫩，肉质肥厚有光泽，要警惕可能海带上添加“孔雀石绿”（ malachite green）染色剂。,孔雀石绿是什么，对人体是否有危害？,物质检索结果,33,CAS is a division of the American Chemical Society. C
23、opyright 2011 American Chemical Society. All rights reserved.,“孔雀石绿”是一种有毒的三苯甲烷类化学物，会致癌，很多国家已经禁用。,物质检索结果,34,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,物质的图谱 物质的实验性质,物质的参考文献 物质的反应信息 物质的商品信息 物质的管控信息,点击查看物质 的详细信息,物质的详细信息,35,CAS is a
24、 division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,按照CAS Role分类的专利、非专利文献列表。对某类文献感兴趣，仅需点击交叉处的 即可方便快捷地获取。,获得物质在分析学中的专利文献,物质的图谱信息,36,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.
25、,Property 性质检索,37,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,依据实验性质检索,Property 性质检索,38,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,依据预测性质检索物质,Property 性质检索的用
26、途,可用于检索符合Lipinski规则的化合物，筛选出有更好的药代动力学性质，有更高的生物利用度，可能成为口服药物的化合物 利用单一的物质信息帮助判断物质的化学结构（通过查找特定分子量的化合物结构，帮助预测分离纯化得到的物质结构）,39,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,40,CAS is a division of the American Chemical Society. Copyright 2
27、011 American Chemical Society. All rights reserved.,SciFinder结构绘制工具,CAS号转换为化学结构,41,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,可卡因的CAS号：50-36-2,Scifinder web 绘图面板,42,CAS is a division of the American Chemical Society. Copyright 2
28、011 American Chemical Society. All rights reserved.,精确结构检索 亚结构检索 相似结构检索,精确结构检索,43,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,立体构型的选择,精确结构检索结果,44,CAS is a division of the American Chemical Society. Copyright 2011 American Chemica
29、l Society. All rights reserved.,可卡因,盐酸可卡因,可卡因混合物,精确结构检索获得物质本身、盐、混合物、聚合物,亚结构检索,45,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,检索黄酮类的物质,亚结构检索结果,46,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical
30、 Society. All rights reserved.,同位素,浏览亚结构检索结果,47,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,取代物,离子,稠环物质,亚结构检索是获得包含绘制的母核结构的所有物质,亚结构检索结果的限定工具,48,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical S
31、ociety. All rights reserved.,化学结构的再次限定,环锁定,原子锁定,化学结构的再次限定,49,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,同位素去除,50,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,
32、去除同位素,相似结构检索,51,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,检索以下的苯并吡唑物质,相似结构检索候选项,52,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,相似度越高，结构越相似,相似结构检索结果,53,CAS i
33、s a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,结构检索小结,精确结构检索：获得物质的盐，聚合物，混合物，配合物等，母体结构不能修改，不能修饰亚结构检索：所画的结构必须存在，母体结构不能修改，但可以被修饰相似结构检索：相似度越高结构越相似，母体结构可以修改，也可以被修饰，用相似度来控制获得的结果,54,CAS is a division of the American Chemical Society. Copyright
34、2011 American Chemical Society. All rights reserved.,提纲,介绍 SciFinder Web中的内容 SciFinder Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,55,CAS is a division of the American Chemical Society. Copyright 2011 Ame
35、rican Chemical Society. All rights reserved.,Scifinder web 中Markush 检索,56,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,Markush结构可以表示一系列物质的结构通式； 专利中以Markush stucture表示可以扩大专利的保护范围，隐含真正有疗效的化合物,Markush检索结果,57,CAS is a division of the
36、American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,直接返回包含该结构的专利文献,查看专利原文,查看权利要求说明书,58,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,59,CAS is a division of the American Chemical Society. Copyr
37、ight 2011 American Chemical Society. All rights reserved.,X1，X2，X3为C、N原子，至少有两个是N原子 R1包括COOH基团，R6包括SH基团 保护了我们设计的目标化合物,设计的目标化合物,专利原文中保护的结构,SciFinder中的Markush检索,Markush检索可直接获得包含该通式结构的所有专利文献； Markush检索是结构检索的补充，可以检索结构检索检不到的专利； 可以帮助做初步的专利评估；,60,CAS is a division of the American Chemical Society. Copyright
38、 2011 American Chemical Society. All rights reserved.,提纲,介绍 SciFinder Web中的内容 SciFinder Web的注册和登陆 SciFinder Web中的检索和后处理 SciFinder Web中的文献检索 SciFinder Web中的物质检索 SciFinder Web中的Markush SciFinder Web中的反应检索 SciFinder Web使用常见问题和网络资源,61,CAS is a division of the American Chemical Society. Copyright 2011 Am
39、erican Chemical Society. All rights reserved.,Scifinder 中反应定义工具,62,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,反应检索,案例一 检索：腈基的还原,63,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All
40、 rights reserved.,64,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,精确反应检索,反应检索结果,65,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,浏览反应记录，发现很多反应是来自于同一篇文献的，可以通过改变反应
41、记录显示方式进行合并。,反应记录显示方式,66,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,一篇文献只出现一条反应记录,反应条件,反应排序功能,Experimental procedure排序,67,CAS is a division of the American Chemical Society. Copyright 2011 American Chemical Society. All rights reserved.,
