1、Blood Vessels,Frank A. Acevedo, PA-C,Vascular Abnormalities,Narrowing of the lumen Thrombosis Weakening of the walls,Normal,Intima - Endothelial Cells Media - Smooth Muscle Cells Adventitia - Connective Tissue,Arteries,Elastic arteries Muscular arteries Arterioles,Endothelium,Anticoagulant/Antithrom
2、boticprostacyclin, thrombomodulin, plasminogen activator, heparin-like molecules ProthromboticVonWillebrand Factor, tissue factor, plasminogen activator inhibitor,Vascular Smooth Muscle,Vasoconstriction Dilatation Collagen, elastin synthesis Cellular proliferation in atherosclerosis,Vascular Disease
3、s,Congenital anomalies Atherosclerosis Hypertensive vascular disease The vasculitides Raynauds disease Aneurysms Vascular tumors,Congenital Anomalies,Berry aneurysms AV fistulas,Atherosclerosis,Elastic and medium sized arteries Atheroma is the basic lesion Age, male, genetic LDL, VLDL Monocytes - ma
4、crophages - foam cells Endothelial injury,Atherosclerosis,Atherosclerosis,Atherosclerosis,Atherosclerosis,Risk Factors,Majordiet and hyperlipidemia, hypertension, cigarette smoking, diabetes Minorobesity, lack of exercise, age, male, family history, stress, BCP, High CHO intake, hyperhomocysteinemia
5、,Hypertension,Idiopathic, essential Renin - Angiotensin Accelerated atherogenesis Hyaline atherosclerosis,Vasculitides,Giant cell arteritis Takayasus arteritis Polyarteritis nodosa Kawasaki disease Wegeners granulomatosis Buergers disease,Giant Cell Arteritis,Rare before age 50 Throbbing pain Visual
6、 disturbances Temporal artery Corticosteroids Polymyalgia rheumatica,Giant Cell Arteritis,Giant Cell Arteritis,Takayasus Arteritis,Fibrous thickening of aortic arch Upper extremity pulselessness Females 15 - 40,Polyarteritis Nodosa,Systemic involvement Fever, weight loss, hypertension Abdominal pain
7、 Melena Muscle aches Motor peripheral neuropathy,Polyarteritis Nodosa,Kawasaki Syndrome,Young children and infants Fever, conjunctival and oral erythema and erosion, edema of the hands and feet, erythema of the palms and soles, desquamation, lymph node enlargement Leading cause of acquired heart dis
8、ease in children,Wegeners Granulomatosis,Acute necrotizing granulomas of the upper and lower reap tract Focal necrotizing vasculitis Renal disease 5th decade of life Immunosuppressive therapy,Wegeners Granulomatosis,Buergers Disease,Thromboangitis obliterans Cigarette smoking “instep” claudication,B
9、uergers Disease,Buergers Disease,Buergers Disease,Raynauds Disease,Small artery, arteriole vasospasm White, blue, red,Raynauds Disease,Raynauds Disease,Aneurysms,Abdominal aorta frequently affected Natural history is to rupture Ischemic intima and media? Male caucasians Early detection,Dissection,Type A Type B Hypertension Double lumen,DeBakey Classification,Dissection,Vascular Tumors,Hemangiomas, Glomus tumor, Vascular ectasias ( nevus, spiders, Osler-Weber-Rendu disease) Angiosarcoma, Kaposis sarcoma,Hemangioma,
