1、Insert Name of presenter Insert Name of hospital,Using antibiotics prudently,- Hospital Prescriber Presentation,Contents of this presentation,Antibiotic resistance a patient safety issue Situation in Europe Drivers of antibiotic resistance Consequences of antibiotic resistance Why inappropriate use
2、of antibiotics contributes to antibiotic resistance the “why” How prudent use of antibiotics can be promoted in hospitals the “how” European Antibiotic Awareness Day a campaign to promote prudent use of antibiotics,2,Antibiotic resistance a patient safety issue,3,Antibiotic resistance a problem in t
3、he present and the future,Antibiotic resistance is an increasingly serious public health problem: resistant bacteria have become an everyday concern in hospitals across Europe.,4,Trends in antibiotic resistance (invasive infections), 2002-2008. Source: European Antimicrobial Resistance Surveillance
4、System (EARSS), 2009.,2002 2007,Methicillin-resistant Staphylococcus aureus (MRSA), blood and spinal fluid,Source: European Antimicrobial Resistance Surveillance System (EARSS), 2008.,5,Methicillin-resistant Staphylococcus aureus (MRSA), EU, 2007: often high, but decreasing in many countries, Countr
5、y with a significant increase (20052007) Country with a significant decrease (20052007),MRSA (%),Source: EARSS & ECDC, 2009,No. of countries,6,Antimicrobial resistance in gram-negative bacteria, EU, 2007: already high or increasing,Country with a significant increase (2005-2007) Country with a signi
6、ficant decrease (2005-2007),Carbapenem-resistant Pseudomonas aeruginosa (%),3rd-gen. ceph.-resistant Klebsiella pneumoniae (%),3rd-gen. ceph.-resistant Escherichia coli (%),Source: EARSS & ECDC, 2009,No. of countries,No. of countries,7,Source: European Surveillance of Antimicrobial Consumption (ESAC
7、), 2010. In: ECDC Annual Epidemiological Report 2010: in press.,Total outpatient antibiotic use in EU Member States, Iceland and Norway, 2008,8,* Total use, i.e. including inpatients (CY, GR, LT). * Reimbursement data, i.e. not including over-the-counter sales without a prescription (ES) * Data from
8、 2007 (MT),Antibiotic resistance A patient safety issue for all hospitals,The emergence, selection and spread of resistant bacteria in hospitals is a major patient safety issue. Infections with antibiotic-resistant bacteria can result in increased patient morbidity and mortality, as well as increase
9、d hospital length of stay.1-2 Antibiotic resistance frequently leads to a delay in appropriate antibiotic therapy.3 Inappropriate or delayed antibiotic therapy in patients with severe infections is associated with worse patient outcomes and sometimes death.4-6,9,1. Cosgrove SE, Carmeli Y. The impact
10、 of antimicrobial resistance on health and economic outcomes. Clin Infect Dis. 2003 Jun 1;36(11):1433-7. 2. Roberts RR, Hota B, Ahmad I, Scott RD, 2nd, Foster SD, Abbasi F, et al. Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antib
11、iotic stewardship. Clin Infect Dis. 2009 Oct 15;49(8):1175-84. 3. Kollef MH, Sherman G, Ward S, Fraser VJ. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999 Feb;115(2):462-74. 4. Ibrahim EH, Sherman G, Ward S, Fraser VJ,
12、 Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000 Jul;118(1):146-55. 5. Lodise TP, McKinnon PS, Swiderski L, Rybak MJ. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus au
13、reus bacteremia. Clin Infect Dis. 2003 Jun 1;36(11):1418-23. 6. Alvarez-Lerma F. Modification of empiric antibiotic treatment in patients with pneumonia acquired in the intensive care unit. ICU-Acquired neumonia Study Group. Intensive Care Med. 1996 May;22(5):387-94.,Antibiotic resistance a daily oc
14、currence in our hospital,In our country / hospital the most frequent resistant infections are the following insert appropriate data where available. These infections have resulted in insert data on additional days of hospitalisation, morbidity, mortality, and costs where available.,10,Why inappropri
15、ate use of antibiotics contributes to antibiotic resistance the “why”,11,In-patients are at high risk of antibiotic-resistant infections,Misuse of antibiotics in hospitals is one of the main factors that drive development of antibiotic resistance.7-9 Patients in hospitals have a high probability of
16、receiving an antibiotic10 and 50% adapt to national figure where available of all antibiotic use in hospitals can be inappropriate.11-12,12,7. Singh N, Yu VL. Rational empiric antibiotic prescription in the ICU. Chest. 2000 May;117(5):1496-9. 8. Lesch CA, Itokazu GS, Danziger LH, Weinstein RA. Multi
17、-hospital analysis of antimicrobial usage and resistance trends. Diagn Microbiol Infect Dis. 2001 Nov;41(3):149-54. 9. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;4
18、6(9):2920-5. 10. Ansari F, Erntell M, Goossens H, Davey P. The European surveillance of antimicrobial consumption (ESAC) point-prevalence survey of antibacterial use in 20 European hospitals in 2006. Clin Infect Dis. 2009 Nov 15;49(10):1496-504. 11. Davey P, Brown E, Fenelon L, Finch R, Gould I, Har
19、tman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543. 12. Willemsen I, Groenhuijzen A, Bogaers D, Stuurman A, van Keulen P, Kluytmans J. Appropriateness of antimicrobial therapy measured by repeated prevalence
20、surveys. Antimicrob Agents Chemother. 2007 Mar;51(3):864-7.,Misuse of antibiotics drives antibiotic resistance,Studies prove that misuse of antibiotics may cause patients to become colonised or infected with antibiotic-resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA), va
21、ncomycin-resistant enterococci (VRE) and highly-resistant Gram-negative bacilli.13-14 Misuse of antibiotics is also associated with an increased incidence of Clostridium difficile infections.15-17,13,13. Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection wit
22、h antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med. 2002 Jun 4;136(11):834-44. 14. Tacconelli E, De Angelis G, Cataldo MA, Mantengoli E, Spanu T, Pan A, et al. Antibiotic usage and risk of colonization and infectio
23、n with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother. 2009 Oct;53(10):4264-9. 15. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst
24、 Rev. 15. 2005(4):CD003543. 16. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 17. Fowler S, Webber A, Cooper BS, Phimister A, Price K, Carter Y, e
25、t al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: a controlled interrupted time series. J Antimicrob Chemother. 2007 May;59(5):990-5.,What is misuse of antibiotics?,14,Misuse of antibiotics can include any of the following18:When antibioti
26、cs are prescribed unnecessarily; When antibiotic administration is delayed in critically ill patients; When broad-spectrum antibiotics are used too generously, or when narrow-spectrum antibiotics are used incorrectly; When the dose of antibiotics is lower or higher than appropriate for the specific
27、patient; When the duration of antibiotic treatment is too short or too long; When antibiotic treatment is not streamlined according to microbiological culture data results.,18. Gyssens IC, van den Broek PJ, Kullberg BJ, Hekster Y, van der Meer JW. Optimizing antimicrobial therapy. A method for antim
28、icrobial drug use evaluation. J Antimicrob Chemother. 1992 Nov;30(5):724-7.,Benefits of prudent use of antibiotics,Prudent use of antibiotics can prevent the emergence and selection of antibiotic-resistant bacteria.19-23 Decreasing antibiotic use have also been shown to result in lower incidence of
29、Clostridium difficile infections.24-26,Rates of Vancomycin-resistant Enterococci in hospital before and after implementation of the antibiotic management program compared with rates in National Nosocomial Infections Surveillance (NNIS) System* hospitals of similar size.27 *NNIS is now the National H
30、ealthcare Safety Network (NHSN).,Rates of nosocomial Clostridium difficile, expressed per 1,000 patient-days, before and after implementation of the antibiotic management program.28,15,19, 24. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescr
31、ibing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543. 20. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;46(9):2920-5. 21, 25, 27, 28.
32、 Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 22. Bradley SJ, Wilson AL, Allen MC, Sher HA, Goldstone AH, Scott GM. The control of hyperendemic g
33、lycopeptide-resistant Enterococcus spp. on a haematology unit by changing antibiotic usage. J Antimicrob Chemother. 23. De Man P, Verhoeven BAN, Verbrugh HA, Vos MC, Van Den Anker JN. An antibiotic policy to prevent emergence of resistant bacilli. Lancet. 2000;355(9208):973-8. 26. Byl B, Clevenbergh
34、 P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.,How prudent use of antibiotics can be promoted in hospitals th
35、e “how”,16,Multifaceted strategies can address and decrease antibiotic resistance in hospitals,Antibiotic prescribing practices and decreasing antibiotic resistance can be addressed through multifaceted strategies including:29-31Use of ongoing education Use of evidence-based hospital antibiotic guid
36、elines and policies Restrictive measures and consultations from infectious disease physicians, microbiologists and pharmacists,17,29. Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database
37、Syst Rev. 2005(4):CD003543. 30. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 31. Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A,
38、et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.,Measures that can decrease antibiotic resistance,18,Measures that guide antibiotic prescribing are likely to
39、 decrease antibiotic resistance in hospitals.32-34 Such measures include:Obtaining cultures Take appropriate and early cultures before initiating empiric antibiotic therapy, and streamline antibiotic treatment based on the culture results35Monitoring local antibiotic resistance patterns Being aware
40、of local antibiotic resistance patterns (antibiograms) enables appropriate selection of initial empiric antibiotic therapy36Consulting specialists Involve infectious disease physicians, microbiologists and pharmacists in your decisions about antibiotic therapy during your patients stay37-39,32, 37.
41、Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543 33, 38. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic
42、 management program conducted during 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 34, 39. Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for b
43、acteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8. 35. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997 Jul;156(1):196-200. 36. Beardsley JR, Williamson JC, Johnson JW, O
44、hl CA, Karchmer TB, Bowton DL. Using local microbiologic data to develop institution-specific guidelines for the treatment of hospital-acquired pneumonia. Chest. 2006 Sep;130(3):787-93.,Our hospital tools for prudent antibiotic prescribing,Hospital antibiogram if available Hospital guidelines if ava
45、ilable Antibiotic stewardship committee if it exists Names of infectious diseases / antibiotic experts,19,Antibiotics handle with care,Misuse of antibiotics leads to resistance40-42 All hospital practitioners can play an active role in reversing the trend of antibiotic-resistant bacteria: Take cultu
46、res before starting antibiotic therapy43 Consult the hospital antibiotic expert44-46, local antibiogram, and hospital antibiotic guidelines Streamline antibiotic therapy based on culture results47,20,40. Singh N, Yu VL. Rational empiric antibiotic prescription in the ICU. Chest. 2000 May;117(5):1496
47、-9. 41. Lesch CA, Itokazu GS, Danziger LH, Weinstein RA. Multi-hospital analysis of antimicrobial usage and resistance trends. Diagn Microbiol Infect Dis. 2001 Nov;41(3):149-54. 42. Lepper PM, Grusa E, Reichl H, Hogel J, Trautmann M. Consumption of imipenem correlates with beta-lactam resistance in
48、Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002 Sep;46(9):2920-5. 43, 47. Rello J, Gallego M, Mariscal D, Sonora R, Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997 Jul;156(1):196-200. 44. Davey P, Brown E, Fenelon L
49、, Finch R, Gould I, Hartman G, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2005(4):CD003543 45. Carling P, Fung T, Killion A, Terrin N, Barza M. Favorable impact of a multidisciplinary antibiotic management program conducted d
50、uring 7 years. Infect Control Hosp Epidemiol. 2003 Sep;24(9):699-706. 47.Byl B, Clevenbergh P, Jacobs F, Struelens MJ, Zech F, Kentos A, et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin Infect Dis. 1999 Jul;29(1):60-6; discussion 7-8.,
