1、 2016 4 4 174 、 。 。 1 5 0 。 1 。 、 2 。 。 1 、 3 。 。 。 、 。 4 。 。 I g A 。 。 、 3 0 0 0 60 、 。 、 。 。 R4 4 6.6 A 1 0 0 3 -5 0 5 2 2 0 1 6 0 4 -0 3 1 -0 3 DOI :1 0 .1 62 86/j.1 0 0 3 -5 0 5 2 .2 0 1 6.0 4 .0 1 1 E-mail Roleandmechanismofhumanintestinalflorainimmunediseases ZHUYu,YANGPing DepartmentofClinic
2、alLaboratory,TianjinHuanhuHospital,Tianjin300060,China Abstract: There were hundreds of types of gut microbiota in human intestines, effecting digestion, nutrition and immunological functions. The disturbance of human intestines gut microbiota could induce immunodeficiency intestinal disease, celiac
3、 disease and non-alcoholic fatty liver disease and there would be reversed above disease through ameliorate gut microbiota constitution by releasing immunological stress. Thispaperreviewedthecorrelationbetweenintestinesgutmicrobiota,immunologicalfunctionanddisease. Keywords Intestinesgutmicrobiota;I
4、mmunologicalsystem;Immunologicaldisease 3 1 - - 2016 4 4 174 、 、 T o l l 、 N o d - R i g - I 。 。 T B T B 。 I g A T 5 - 6 。 2 2 . 1 。 5 0 % 、 、 H I V / A I D S 7 。 。 B B c K O 。 I g A 8 。 2 . 2 T I L - 1 5 。 9 - 1 0 。 。 T N F - I L - 1 0 。 1 1 。 2 . 3 。 T N F - 1 2 。 3 、 。 1 3 。 、 1 4 。 4 。 1 5 - 1 6
5、 。 。 1 QIN JJ LI RQ RAES J et al. A human gut microbial gene cata- logue established by metagenomic sequencing J. Nature 2010 464(7285) 59-65. 2 Valentina T Fredrik B. Functional interactions between the gut mi- crobiotaandhostmetabolismJ.Nature 2012 489(7415) 242-249. 3 Hooper LV Littman DR Macpher
6、son AJ. Interactions between the microbiota and the immune systemJ. Science 2012 336 6086 1268-1273. 4 Herbst T Sichelstiel A Schar C et al.Dysregu-lation of allergic air- wayinflammationintheabsenceofmicrobialcolonization J.AmJ RespirCritCareMed 2011 184 2 198-205. 5 ShulzhenkoN MorgunA Hsiao W et
7、al.Cross-talk between Blym- phocytes microbiota and the intestinal epithelium governs immuni- ty versus metabolism in the gut J.Nat Med 2011 17 12 1585-1593. 6 Kupfer SS Jabri B.Pathophysiology of celiac diseaseJ.Gastrointest EndoscClinNAm 2012 22 639-660. 7 Shoaie S Ghaffari P Kovatcheva-Datchary P
8、 et al.Quantifying Di- et-Induced Metabolic Changes of the Human Gut MicrobiomeJ. CellMetab 2015 22(2) 320-331. 8 Di Luccia B Crescenzo R Mazzoli A et al.Rescue of Fructose-In- ducedMetabolicSyndromebyAntibioticsor Faecal Transplantation inaRatModelofObesityJ.PLOSOne 2015 10(8) e0134893. 9 Ponomarov
9、a O Patil KR.Metabolic interactions in microbial com- 3 2 - - 2016 4 4 174 munities untangling the Gordian knot J. Curr Opin Microbiol 2015 27 37-44. 10 Rizzello M De Angelis F Campanile FC et al.Effect of gastroin- testinal surgical manipulation on metabolic syndrome a focus on metabolic surgery J.
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11、bowel disease and treatment J. GenomeBiol 2012 13 R79. 13EverardA LazarevicV DerrienM etal.Responsesofgutmicrobio- ta and glucose and lipid metabolism to prebiotics in ge-netic obese and diet-induced leptin-resistant mice J.Diabetes 2011 60 11 2775-2786. 14 .2 J. 2015 951(21) 52-53 62. 15 Nayfach S
12、Bradley PH Wyman SK et al.Automated and Accurate Estimation of Gene Family Abundance from Shotgun Metagenomes J.PLOSComputBiol 2015 11(11) e1004573. 16 Mikkelsen KH Frost M Bahl MI et al. Effect of Antibiotics on GutMicrobiota GutHormonesandGlucoseMetabolism J.PLOS One 2015 10(11) e0142352. 300011 、
13、 。 90 95 。 。 。 16 20 。 1884 。 。 R656.2 A 1003-5052 2016 04-033-03 DOI :10.16286/j.1003-5052.2016.04.012 E-mail Statusandadvancementoftreatmentofexternalabdominalhernia LIUZhi DepartmentofSurgery Tianjinpreventionandtreatmentcenterforoccupationaldiseases, Tianjin300011,China Abstract: External abdom
14、indl hernia is formed by introperitoeal organs or tissues and the parietal peritoneum in the abdominal cavity swell to the surface through the abdominal wall. This is one of the common diseases of surgery. Among these inguinal hernias incidence accounts for about 90% 95%. Hernia repair surgery is th
15、e most common and fundamental operation. In history, the treatment of inguinal hernia has experienced a longprocess ofdevelopment. From sixteenth Century, with the introduction ofthe concept of modern anatomy, the operation of the hernia began to the follow the anatomical structure. And through the
16、continuous efforts of the surgeon, until the beginning of the twentieth Century, the modern surgical operation mode of the inguinal hernia was established. Since 1884 Bassini Nepal created a real anatomical hernia repair, through doctors efforts gradually established the tension hernia repair and the tension free hernia repair operation and developed to the laparoscopic hernia repair operation. All kinds of 33 - -
