1、5h Z王倩怡,贾继东首都医科大学附属北京友谊医院肝病中心, 北京 100050nullK1nullnullh Bhy %hb52/3hi# s ,h1VC n, P 4bh ZSB8 bnull1oMnullnullh; ms |: R575null null nullDS M : Anull null nullcI|: 1006- 5709( 2010) 12- 1063- 03null null null l : 2009null11null16Progress in diagnosis and therapy of hepatic sarcoidosisWANG Qiany,i JIA
2、 JidongLiver Research Center, Beijing FriendshipH ospitalAffiliated to CapitalM edicalUniversity, Beijing 100050, ChinanullAbstractnullnull H epatic sarcoidosis is a benign hepatic neoplasm, which is an idiopathic system ic inflamm atory granulomnullatous disorder. A lthough it can be identified in
3、approximately two thirds of patientsw ith system ic sarcoidosis, it is unnullcommon as a liver disease, so its diagnosis becomes difficul.t W e reviewed the clinicalm anifestations, diagnosis andtherapy ofhepatic sarcoidosis.nullKey wordsnullnull H epatic sarcoidosis; Diagnosis; Therapynull nullh Bh
4、y a 2“d s %h,hMCd “ h + 1bh V # | %h “5VC#h f, Zg8b3. 1null0 null “ - hBL0bX L r ,+Y k ? SUk 2, r bh, Va ?Sah # = , #8T, O ?E%hZbKennedy 963 s h ?C1/3 s, 1/3ss,71/3null1064nullhhnull 2010 M1219 12 null Chin JGastroenterolHepato,l Dec 2010, Vo.l 19, No. 12 Q,2 s W?Zb “ - Ha4a 5Bin, 8b 4%hE 0 s T,JO V
5、 ? BT,0 ?% dbTNFnullnull1,B bi JO ? ?_ ? us# JO#T, hZT 18b oSa oSa:w09;h , Kh a$d v, r b ( Inflixim ab) B FTNFnullnull X HF8,1 A1, M0 hh 19,y B 0, rB , ONL,# “- ?Wb = A, V ?B h f%hZbAlenezi 20B = AaFA U # B h,y H Uh7E , v,69 , ALPGGT (/85% 90%,#F_4 UhM AZbyh ,B “5 rb3. 2nullMnull yh h,M bLipson 212
6、117 Ms?C,yhM0. 3%, 7 M1 M 3i q100%, 5 M 3i q86%,y hyMM1 (As,hM? 3$% 1 M bM?59 s j,V ? f4 “1,#ypM aCTi s a 22b ID 1 IannuzziMC, Rybicki BA, Teirstein AS. Sarcoidosis J. N Engl JM ed, 2007, 357: 2153null2165. 2 GurrieriC, BortoliM, BrunettaE, et a.l Cytokines, chemokines andother biomolecularmarkers i
7、n sarcoidosis J. SarcoidosisV aseD ifuseLungD is, 2005, 22( 1): 9null14. 3, , X.+ yVCh2 J. LD, 2007, 23( 1): 46. 4 SchurmannM, Lympany PA, ReichelP, et a.l Fam ilial sarcoidosis islinked to themajorhistocompatibility complex region J. Am JRespirCrit CareM ed, 2000, 162( 3 Pt 1): 861null864. 5 Goldbe
8、rgHJ, F iedler D, W ebb A, et a.l Sarcoidosis after treatmentw ith interferonnullalpha: a case series and review of the literature J.RespirM ed, 2006, 100( 11): 2063null2068. 6 , +,; . h r#Y J. , 2003, 26( 1): 14null17. 7 The 6th WASOG M eeting. Sarcoidosis VascD iffuse Lung D is, 1999,16: 5null54.
9、8 VannozziG, TozziA, ChibbaroG, et a.l H epatic andmesenteric sarnullcoidosisw ithout thoracic involvement: acase of severe noncirrhotic pornulltal hypertension and successful pregnancy J. Eur J GastroenterolHepato,l 2008, 20( 10): 1032null1035. 9 Kennedy PT, ZakariaN, Modaw iSB, et a.l Natural hist
10、ory of hepaticsarcoidosis and its response to treatment J. Eur JGastroenterolH epnullato,l 2006, 18( 7): 721null726. 10 Baughman R. Sarcoidosis M . New Y ork: Taylor& Francis, 2006:435null462. 11 K ieszko R, K raw czyk P, Chocholska S, et a.l Tumor necrosis factorreceptors ( TNFRs) on T lymphocytes
11、and solubleTNFRs in differentclinical courses of sarcoidosis J. RespirM ed, 2007, 101 ( 3):645null654. 12 HataM, SugisakiK, M iyazaki E, et a.l C irculating ILnull12 p40 is innullcreased in the patientsw ith sarcoidosis, correlationw ith clinicalmarknullers J. InternM ed, 2007, 46( 17): 1387null1393
12、. 13 Ashitani J, M atsumoto N, NakazatoM. Elevated alphanulldefensin levnullels in plasma of patients w ith pulmonary sarcoidosis J. Respirolonullgy, 2007, 12( 3): 339null345. 14 HauensteinK, HellerT. M odern, nonnullinvasivediagnosticof focal livnuller lesions J. Rontgenpraxis, 2005, 55( 6): 207nul
13、l221. 15 .h 1 2/VC J.S 2D, 2008, 24( 3): 269. 16 HunninghakeGW, CostabelU, AndoM, et a.l ATS/ERS/WASOGstatement on sarcoidosis: American Thoracic Society/European RenullspiratorySociety/World A ssociation of Sarcoidosis and otherG ranulonullmatous D isorders J. SarcoidosisV ascD iffuseLung Dis, 1999
14、, 16( 2): 149null173. 17 JudsonMA. Themanagement of sarcoidosis by the primary carephysinullcian J. Am JM ed, 2007, 120( 5): 403null407. 18 Z isman DA, M cCuneW J, T inoG, et a.l Drugnullinduced pneumonitis:the role of methotrexate J. Sarcoidosis Vasc D iffuse Lung D is,2001, 18( 3): 243null252. 19
15、Baughman RP, IannuzziM. Tumournecrosis factor in sarcoidosis andits potential for targeted therapy J. BioD rugs, 2003, 17 ( 6):425null431. 20 A leneziB, Lamoureux E, A lpert L, et a.l Effect of ursodeoxycholicacid on granulomatous liver disease due to sarcoidosis J. D ig D isSc,i 2005, 50( 1): 196nu
16、ll200. 21 L ipson EJ, F ielM I, F lorman SS, et a.l Patient and graft outcomesfollow ing liver transplantation for sarcoidosis J. Clin T ransplant,2005, 19( 4): 487null491. 22 Shibolet O, KalishY, W olfD, et a.l Exacerbation ofPulmonary Sarnullcoidosis A fterL iverT ransplantation J. J Clin Gastroentero,l 2002,35( 4): 356null358.null1065nullhhnull 2010 M1219 12 null Chin JGastroenterolH epato,l Dec 2010, Vo.l 19, No. 12
